Search Results - "Calder, Mathew"

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance by Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.

“…To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric…”
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Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold by Carswell, Emma, Heinrich, Timo, Petersson, Carl, Gunera, Jakub, Garg, Sakshi, Schwarz, Daniel, Schlesiger, Sarah, Fischer, Frank, Eichhorn, Thomas, Calder, Mathew, Smith, Geoffrey, MacDonald, Ellen, Wilson, Hollie, Hazel, Katherine, Trivier, Elisabeth, Broome, Rebecca, Balsiger, Alexander, Sirohi, Sameer, Musil, Djordje, Freire, Filipe, Schilke, Heike, Dillon, Christian, Wienke, Dirk

“…[Display omitted] •Structure-based optimisation of an HTS hit delivered both reversible and covalent TEAD inhibitors.•Both lead molecules displayed TEAD…”
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Abstract P056: Polθ inhibitors elicit BRCA -gene synthetic lethality and target PARP inhibitor resistance by Zatreanu, Diana A., Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert, Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M, Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Steve, Smith, Graeme C. M., Lord, Christopher J.

“…Abstract To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight, allosteric inhibitors of the…”
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Structural Control of the Photodynamics of Boron−Dipyrrin Complexes by Kee, Hooi Ling, Kirmaier, Christine, Yu, Lianhe, Thamyongkit, Patchanita, Youngblood, W. Justin, Calder, Matthew E, Ramos, Lavoisier, Noll, Bruce C, Bocian, David F, Scheidt, W. Robert, Birge, Robert R, Lindsey, Jonathan S, Holten, Dewey

“…Boron−dipyrrin chromophores containing a 5-aryl group with or without internal steric hindrance toward aryl rotation have been synthesized and then…”
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Development of REDX05194, a Novel, Potent and Selective Inhibitor of Bruton's Tyrosine Kinase (BTK) As a Potential Treatment for B-Cell Malignancies by Walker, Victoria, Guisot, Nicolas E S, Best, Stuart, Talab, Fatima, Lucas, Catherine L, Refuerzo, Julienne, Calder, Mathew, Proctor, Lauren, Muller, Melanie, Ho, Kelvin, Chappell, Rose, Emmerich, Juliette, Harmon, Shona, Bingham, Matilda, Campbell, Mary-Ann, Armer, Richard

“…The B-cell receptor (BCR) signaling pathway is required for the survival, activation, proliferation and differentiation of B-cells. Bruton's Tyrosine Kinase…”
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Abstract 5697: Targeting PARP inhibitor resistance with Polθ inhibitors by Zatreanu, Diana, Robinson, Helen, Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert, Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall, Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luted, Novo, Daniela, Knight, Eleanor, Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew N., Boulton, Simon, Higgins, Geoff, Pettitt, Stephen J., Smith, Graeme C., Lord, Christopher J.

“…Abstract To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the…”
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