Search Results - "Calcutt, N"

Efficacy of a long-acting C-peptide analogue against peripheral neuropathy in streptozotocin-diabetic mice by Jolivalt, C. G., Rodriguez, M., Wahren, J., Calcutt, N. A.

“…Aims To investigate the efficacy of a pegylated C‐peptide (Peg‐C‐peptide) against indices of peripheral neuropathy in a mouse model of type 1 diabetes and to…”
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GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice by Jolivalt, C. G., Fineman, M., Deacon, C. F., Carr, R. D., Calcutt, N. A.

“…Aim: Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone that induces glucose‐dependent insulin secretion and may have neurotrophic properties. Our aim was…”
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Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor by CALCUTT, N. A, FRESHWATER, J. D, MIZISIN, A. P

“…Sensory neuropathy in diabetic patients frequently presents itself as progressive loss of thermal perception, while some patients describe concurrent…”
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Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab) by Biessels, G.J., Bril, V., Calcutt, N.A., Cameron, N.E., Cotter, M.A., Dobrowsky, R., Feldman, E.L., Fernyhough, P., Jakobsen, J., Malik, R.A., Mizisin, A.P., Oates, P.J., Obrosova, I.G., Pop-Busui, R., Russell, J.W., Sima, A.A., Stevens, M.J., Schmidt, R.E., Tesfaye, S., Veves, A., Vinik, A.I., Wright, D.E., Yagihashi, S., Yorek, M.A., Ziegler, D., Zochodne, D.W.

“…NIDDK, JDRF, and the Diabetic Neuropathy Study Group of EASD sponsored a meeting to explore the current status of animal models of diabetic peripheral…”
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Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes by Jolivalt, C. G., Aghanoori, M. R., Navarro-Diaz, M. C., Han, M. M., Sanchez, G., Guernsey, L., Quach, D., Johe, K., Fernyhough, P., Calcutt, N. A.

“…Aims. Mitochondrial dysfunction contributes to many forms of peripheral and central nervous system degeneration. Therapies that protect mitochondrial number…”
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Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease by Jolivalt, C.G, Calcutt, N.A, Masliah, E

“…Abstract There is an increasing awareness that diabetes has an impact on the CNS and that diabetes is a risk factor for Alzheimer's disease (AD). Links between…”
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Prospective DPYD testing in colorectal cancer patients in a realworld UK population by Eccles, B K, Harle, A S, Pullinger, S, Holling, C, Ingram, A, Stark, S, Bunce, M, Melville, G, Gibbins, J, Calcutt, N, Hickish, T, Flubacher, M, Marinaki, T

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An Introduction to the History and Controversies of the Pathogenesis of Diabetic Neuropathy by Fernyhough, P, Calcutt, N A

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New Directions in Diabetic Neuropathy: Evolution or Extinction? by Fernyhough, P, Calcutt, N A

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An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy by Calcutt, N A, Fernyhough, P

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A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy by Calcutt, N A, Fernyhough, P

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Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats by JOLIVALT, C. G, JIANG, Y, FRESHWATER, J. D, BARTOSZYK, G. D, CALCUTT, N. A

“…We investigated spinal and peripheral kappa opioid systems in diabetic rats. Dynorphin A, N-methyl-D-aspartate (NMDA) and kappa opioid receptor (KOR) were…”
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Neuronal Nitric Oxide Synthase mRNA Upregulation in Rat Sensory Neurons after Spinal Nerve Ligation: Lack of a Role in Allodynia Development by Luo, Z. David, Chaplan, S. R, Scott, B. P, Cizkova, D, Calcutt, N. A, Yaksh, T. L

“…Pharmacological evidence suggests a functional role for spinal nitric oxide (NO) in the modulation of thermal and/or inflammatory hyperalgesia. To assess the…”
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Spinal pharmacology of tactile allodynia in diabetic rats by Calcutt, Nigel A., Chaplan, Sandra R.

“…1 Rats develop tactile allodynia to stimulation of the plantar surface of the hindpaw with von Frey filaments within days of the onset of…”
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Gabapentin prevents hyperalgesia during the formalin test in diabetic rats by Ceseña, R.M, Calcutt, N.A

“…The anticonvulsant agent gabapentin exhibits antihyperalgesic properties in animal models of neuropathic pain. Diabetic rats display increased nocifensive…”
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Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine by Calcutt, N A, Jorge, M C, Yaksh, T L, Chaplan, S R

“…Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks. Allodynia was prevented by insulin therapy that…”
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Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats by Calcutt, Nigel A, Stiller, Carl-Olav, Gustafsson, Henrik, Malmberg, Annika B

“…Pharmacologic studies implicate the involvement of substance P in spinal nociceptive processing during the formalin test. However, no direct measurement of the…”
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Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats by KALICHMAN, M. W, CALCUTT, N. A

“…Patients with diabetes may have peripheral neuropathy, which may have clinical implications for the use of regional nerve block. The effects of local…”
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Prosaptide prevents paclitaxel neurotoxicity by Campana, W M, Eskeland, N, Calcutt, N A, Misasi, R, Myers, R R, O'Brien, J S

“…Paclitaxel (Taxol), a chemotherapeutic agent used to treat breast and ovarian tumors, has been reported to induce a predominantly sensory neuropathy…”
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Regulation of Expression of the Sensory Neuron-Specific Sodium Channel SNS in Inflammatory and Neuropathic Pain by Okuse, Kenji, Chaplan, Sandra R., McMahon, Stephen B., Luo, Z.David, Calcutt, Nigel A., Scott, Brian P., Akopian, Armen N., Wood, John N.

“…Increased voltage-gated sodium channel activity may contribute to the hyperexcitability of sensory neurons in inflammatory and neuropathic pain states. We…”
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