Search Results - "Calay, Ediz S."

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance by Yang, Ling, Li, Ping, Fu, Suneng, Calay, Ediz S., Hotamisligil, Gökhan S.

“…Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both genetic and…”
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The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans by Tirosh, Amir, Calay, Ediz S, Tuncman, Gurol, Claiborn, Kathryn C, Inouye, Karen E, Eguchi, Kosei, Alcala, Michael, Rathaus, Moran, Hollander, Kenneth S, Ron, Idit, Livne, Rinat, Heianza, Yoriko, Qi, Lu, Shai, Iris, Garg, Rajesh, Hotamisligil, Gökhan S

“…The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and endogenously produced by gut microbiota…”
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A hormone complex of FABP4 and nucleoside kinases regulates islet function by Prentice, Kacey J., Saksi, Jani, Robertson, Lauren T., Lee, Grace Y., Inouye, Karen E., Eguchi, Kosei, Lee, Alexandra, Cakici, Ozgur, Otterbeck, Emily, Cedillo, Paulina, Achenbach, Peter, Ziegler, Anette-Gabriele, Calay, Ediz S., Engin, Feyza, Hotamisligil, Gökhan S.

“…The liberation of energy stores from adipocytes is critical to support survival in times of energy deficit; however, uncontrolled or chronic lipolysis…”
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Real-world effectiveness of sotrovimab in preventing hospitalization and mortality in high-risk patients with COVID-19 in the United States: A cohort study from the Mayo Clinic electronic health records by Bell, Christopher F, Gibbons, Daniel C, Drysdale, Myriam, Birch, Helen J, Lloyd, Emily J, Patel, Vishal, Carpenter, Corinne, Carlson, Katherine, Calay, Ediz S, Puranik, Arjun, Wagner, Tyler E, O'Horo, John C, Razonable, Raymund R

“…To describe outcomes of high-risk patients with coronavirus disease 2019 (COVID-19) treated with sotrovimab, other monoclonal antibodies (mAbs), or antivirals,…”
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Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis by ten Freyhaus, Henrik, Calay, Ediz S., Yalcin, Abdullah, Vallerie, Sara N., Yang, Ling, Calay, Zerrin Z., Saatcioglu, Fahri, Hotamisligil, Gökhan S.

“…The six-transmembrane protein Stamp2 plays an important role in metabolically triggered inflammation and insulin action. We report that Stamp2 is expressed in…”
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S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction by Yang, Ling, Calay, Ediz S., Fan, Jason, Arduini, Alessandro, Kunz, Ryan C., Gygi, Steven P., Yalcin, Abdullah, Fu, Suneng, Hotamisligil, Gökhan S.

“…The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic inflammation…”
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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism by Tirosh, Amir, Tuncman, Gurol, Calay, Ediz S., Rathaus, Moran, Ron, Idit, Tirosh, Amit, Yalcin, Abdullah, Lee, Yankun G., Livne, Rinat, Ron, Sophie, Minsky, Neri, Arruda, Ana Paula, Hotamisligil, Gökhan S.

“…Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…”
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Turning off the inflammatory, but not the metabolic, flames by Calay, Ediz S., Hotamisligil, Gökhan S.

“…Metabolically driven, chronic, low-grade inflammation has a crucial role in the pathogenesis of obesity and type 2 diabetes, and multiple stress-signaling…”
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Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes by Burak, M Furkan, Inouye, Karen E, White, Ariel, Lee, Alexandra, Tuncman, Gurol, Calay, Ediz S, Sekiya, Motohiro, Tirosh, Amir, Eguchi, Kosei, Birrane, Gabriel, Lightwood, Daniel, Howells, Louise, Odede, Geofrey, Hailu, Hanna, West, Shauna, Garlish, Rachel, Neale, Helen, Doyle, Carl, Moore, Adrian, Hotamisligil, Gökhan S

“…The lipid chaperone aP2/FABP4 has been implicated in the pathology of many immunometabolic diseases, including diabetes in humans, but aP2 has not yet been…”
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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism by Tirosh, Amir, Tuncman, Gurol, Calay, Ediz S., Rathaus, Moran, Ron, Idit, Tirosh, Amit, Yalcin, Abdullah, Lee, Yankun G., Livne, Rinat, Ron, Sophie, Minsky, Neri, Arruda, Ana Paula, Hotamisligil, Gökhan S.

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Mo1590 RELIABILITY OF USING BINARY BIOCHEMICAL CRITERIA AT MONTH 6 FOR PREDICTING TREATMENT OUTCOMES IN PRIMARY BILIARY CHOLANGITIS by Meloni, Seema T., Zein, Claudia O., Iyengar, Anushree R., Calay, Ediz S., Wagner, Tyler E., Yenukoti, Rohit K., Gattolliat, Olivier, Doban, Vitalii, Juran, Brian D., Lazaridis, Konstantinos N.

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Mo1604 REAL-WORLD STUDY TO EXAMINE BASELINE CHARACTERISTICS, CONCURRENT AUTOIMMUNE CONDITIONS AND ENVIRONMENTAL EXPOSURES AS POSSIBLE PREDICTORS OF RESPONSE TO URSODEOXYCHOLIC ACID FOR THE TREATMENT OF PRIMARY BILIARY CHOLANGITIS by Meloni, Seema T., Zein, Claudia O., Iyengar, Anushree R., Calay, Ediz S., Wagner, Tyler E., Yenukoti, Rohit K., Gattolliat, Olivier, Doban, Vitalii, Juran, Brian D., Lazaridis, Konstantinos N.

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THU-135 Real-world study of reasons for non-utilization of second-line treatment in patients with primary biliary cholangitis by Meloni, Seema T., Zein, Claudia O., Smither, Allison R., Iyengar, Anushree, Calay, Ediz S., Wagner, Tyler E., Yenukoti, Rohit K., Pommie, Christelle, Gattolliat, Olivier, Doban, Vitalii, Juran, Brian D., Lazaridis, Konstantinos N.

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Phenotypic and endotypic features of COPD associated with lung cancer development by Lee, Kyeryoung, Cohn, David, Liu, Zongzhi, Ai, Lei, Paek, Hunki, Jin, Lan, Raja, Kalpana, Li, Minghao, Zhang, Xingmin, Jun, Tomi, Higashi, Mitchell, Oh, William, Calay, Ediz S., Savic, Radoslav, Ghosh, Krish, Kasarskis, Andrew, Mullaney, Tommy, Pan, Qi, Schadt, Eric, Wang, Xiaoyan

“…e13563 Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with multiple phenotypes and endotypes and associated with lung…”
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Real-World Treatment Outcomes of Teclistamab Under an Outpatient Model for Step-up Dosing Administration by Sandahl, Tyler B., Soefje, Scott A., Calay, Ediz S., Lin, Yi, Fonseca, Rafael, Ailawadhi, Sikander, Parrondo, Ricardo, Lin, Dee, Wu, Bingcao, Silvert, Eli, Kim, Nina, Carpenter, Corinne, Wagner, Tyler E., Fowler, Jessica, Hester, Laura, Marshall, Alexander, Stoy, Patrick, Gifkins, Dina, Kumar, Shaji Kunnathu

“…Background Teclistamab, the first-in-class B-cell maturation antigen (BCMA) x CD3 bispecific therapy was recently approved by the FDA for the treatment of…”
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Inter-cellular transmission of hepatic ER stress in obesity disrupts systemic metabolism by Tirosh, Amir, Tuncman, Gurol, Calay, Ediz S., Rathaus, Moran, Ron, Idit, Tirosh, Amit, Yalcin, Abdullah, Lee, Yankun G, Livne, Rinat, Ron, Sophie, Minsky, Neri, Arruda, Ana Paula, Hotamisligil, Gökhan S.

“…Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…”
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Real-world effectiveness of sotrovimab in preventing hospitalization and mortality in high-risk patients with COVID-19 in the United States: A cohort study from the Mayo Clinic electronic health records by Christopher F. Bell, Daniel C. Gibbons, Myriam Drysdale, Helen J. Birch, Emily J. Lloyd, Vishal Patel, Corinne Carpenter, Katherine Carlson, Ediz S. Calay, Arjun Puranik, Tyler E. Wagner, John C. O’Horo, Raymund R. Razonable

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METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction by Yang, Ling, Calay, Ediz S, Fan, Jason, Arduini, Alessandro, Kunz, Ryan C, Gygi, Steven P, Yalcin, Abdullah, Fu, Suneng, Hotamisligil, Gökhan S

“…The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic inflammation…”
Get full text