Search Results - "Calaminus, Simon D.J."

Analysis of intact phosphoinositides in biological samples by Pettitt, Trevor R., Dove, Stephen K., Lubben, Anneke, Calaminus, Simon D.J., Wakelam, Michael J.O.

“…It is now apparent that each of the known, naturally occurring polyphosphoinositides, the phosphatidylinositol monophosphates (PtdIns3P, PtdIns4P, PtdIns5P),…”
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NIR-quantum dots in biomedical imaging and their future by Gil, Hélio M., Price, Thomas W., Chelani, Kanik, Bouillard, Jean-Sebastien G., Calaminus, Simon D.J., Stasiuk, Graeme J.

“…Fluorescence imaging has gathered interest over the recent years for its real-time response and high sensitivity. Developing probes for this modality has…”
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Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation by Coupland, Charlie A., Naylor-Adamson, Leigh, Booth, Zoe, Price, Thomas W., Gil, Helio M., Firth, George, Avery, Michelle, Ahmed, Yusra, Stasiuk, Graeme J., Calaminus, Simon D.J.

“…Approximately 17.3% of the global population exhibits an element of zinc (Zn2+) deficiency. One symptom of Zn2+ deficiency is increased bleeding through…”
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Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets by Gil, Hélio M., Booth, Zoe, Price, Thomas W., Lee, Jessica, Naylor‐Adamson, Leigh, Avery, Michelle, Muravitskaya, Alina, Hondow, Nicole, Allsup, David, Schneider, Jürgen E., Naseem, Khalid, Adawi, Ali M., Bouillard, Jean‐Sebastien G., Chamberlain, Thomas W., Calaminus, Simon D. J., Stasiuk, Graeme J.

“…InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal‐based QDs. Given their intrinsic fluorescent…”
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The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration by Zech, Tobias, Calaminus, Simon D J, Caswell, Patrick, Spence, Heather J, Carnell, Michael, Insall, Robert H, Norman, Jim, Machesky, Laura M

“…The actin cytoskeleton provides scaffolding and physical force to effect fundamental processes such as motility, cytokinesis and vesicle trafficking. The…”
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Podosomes in adhesion, migration, mechanosensing and matrix remodeling by Schachtner, Hannah, Calaminus, Simon D. J., Thomas, Steven G., Machesky, Laura M.

“…Cells use various actin‐based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin…”
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Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane by Schachtner, Hannah, Calaminus, Simon D.J., Sinclair, Amy, Monypenny, James, Blundell, Michael P., Leon, Catherine, Holyoake, Tessa L., Thrasher, Adrian J., Michie, Alison M., Vukovic, Milica, Gachet, Christian, Jones, Gareth E., Thomas, Steven G., Watson, Steve P., Machesky, Laura M.

“…Megakaryocytes give rise to platelets via extension of proplatelet arms, which are released through the vascular sinusoids into the bloodstream. Megakaryocytes…”
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Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny by Calaminus, Simon D J, Guitart, Amelie V, Guitart, Amelie, Sinclair, Amy, Schachtner, Hannah, Watson, Steve P, Holyoake, Tessa L, Kranc, Kamil R, Machesky, Laura M

“…The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific…”
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Practical Considerations of Dissolved Oxygen Levels for Platelet Function under Hypoxia by Kusanto, Branden, Gordon, Andrew, Naylor-Adamson, Leigh, Atkinson, Lloyd, Coupland, Charlie, Booth, Zoe, Ahmed, Yusra, Pires, Isabel M, Stasiuk, Graeme J, Sturmey, Roger, Calaminus, Simon D J, Arman, Mònica

“…Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea…”
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Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility by Naylor-Adamson, Leigh, Price, Thomas W, Booth, Zoe, Stasiuk, Graeme J, Calaminus, Simon D J

“…Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to…”
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Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo by Schachtner, Hannah, Li, Ang, Stevenson, David, Calaminus, Simon D.J., Thomas, Steven G., Watson, Steve P., Sixt, Michael, Wedlich-Soldner, Roland, Strathdee, Douglas, Machesky, Laura M.

“…We describe here the development and characterization of a conditionally inducible mouse model expressing Lifeact-GFP, a peptide that reports the dynamics of…”
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Actin on trafficking: Could actin guide directed receptor transport? by Simon D.J. Calaminus, Laura M. Machesky, Tobias Zech

“…Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in…”
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Actin on trafficking: Could actin guide directed receptor transport? by Zech, Tobias, Calaminus, Simon D.J., Machesky, Laura M.

“…Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in…”
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Identification of a novel, actin‐rich structure, the actin nodule, in the early stages of platelet spreading by CALAMINUS, S. D. J., THOMAS, S., McCARTY, O. J. T., MACHESKY, L. M., WATSON, S. P.

“…Background: During platelet spreading, the actin cytoskeleton undergoes marked changes, forming filopodia, lamellipodia and stress fibres. In the present…”
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MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability by CALAMINUS, S. D. J., AUGER, J. M., MCCARTY, O. J. T., WAKELAM, M. J. O., MACHESKY, L. M., WATSON, S. P.

“…Background: MyosinIIs are adenosine triphosphate‐driven molecular motors that form part of a cell’s contractile machinery. They are activated by…”
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Vav family proteins are required for optimal regulation of PLCγ2 by integrin αIIbβ3 by Pearce, Andrew C., Mccarty, Owen J. T., Calaminus, Simon D. J., Vigorito, Elena, Turner, Martin, Watson, Steve P.

“…Vav proteins belong to the family of guanine-nucleotide-exchange factors for the Rho/Rac family of small G-proteins. In addition, they serve as important…”
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A major role for Scar/WAVE‐1 downstream of GPVI in platelets by CALAMINUS, S. D. J., MCCARTY, O. J. T., AUGER, J. M., PEARCE, A. C., INSALL, R. H., WATSON, S. P., MACHESKY, L. M.

“…Background: The small GTPase Rac1 plays a critical role in lamellipodia assembly in platelets on matrix proteins in the absence or presence of G…”
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Studies on the actin-binding protein HS1 in platelets by Thomas, Steven G, Calaminus, Simon D J, Auger, Jocelyn M, Watson, Stephen P, Machesky, Laura M

“…The platelet cytoskeleton mediates the dramatic change in platelet morphology that takes place upon activation and stabilizes thrombus formation. The Arp2/3…”
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