Search Results - "Calamia, Justina C"

Pharmacokinetics of Tacrolimus During Pregnancy by SONGMAO ZHENG, EASTERLING, Thomas R, UMANS, Jason G, MIODOVNIK, Menachem, CALAMIA, Justina C, THUMMEL, Kenneth E, SHEN, Danny D, DAVIS, Connie L, HEBERT, Mary F

“…Information on the pharmacokinetics of tacrolimus during pregnancy is limited to case reports despite the increasing number of pregnant women being prescribed…”
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Variability in Expression of CYP3A5 in Human Fetal Liver by Vyhlidal, Carrie A, Pearce, Robin E, Gaedigk, Roger, Calamia, Justina C, Shuster, Diana L, Thummel, Kenneth E, Leeder, J Steven

“…Members of the cytochrome P450 3A (CYP3A) subfamily of drug metabolizing enzymes exhibit developmental changes in expression in human liver characterized by a…”
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Identification of CYP3A7 for glyburide metabolism in human fetal livers by Shuster, Diana L., Risler, Linda J., Prasad, Bhagwat, Calamia, Justina C., Voellinger, Jenna L., Kelly, Edward J., Unadkat, Jashvant D., Hebert, Mary F., Shen, Danny D., Thummel, Kenneth E., Mao, Qingcheng

“…Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have…”
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EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM by WEILI HUANG, LIN, Yvonne S, MCCONN, Donavon J, CALAMIA, Justina C, TOTAH, Rheem A, ISOHERRANEN, Nina, GLODOWSKI, Mary, THUMMEL, Kenneth E

“…CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in product regioselectivity and formation activity. To further explore…”
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Assessing Transporter‐Mediated Natural Product‐Drug Interactions Via In vitro‐In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail by Nguyen, James T., Tian, Dan‐Dan, Tanna, Rakshit S., Hadi, Deena L., Bansal, Sumit, Calamia, Justina C., Arian, Christopher M., Shireman, Laura M., Molnár, Bálint, Horváth, Miklós, Kellogg, Joshua J., Layton, Matthew E., White, John R., Cech, Nadja B., Boyce, Richard D., Unadkat, Jashvant D., Thummel, Kenneth E., Paine, Mary F.

“…The botanical natural product goldenseal can precipitate clinical drug interactions by inhibiting cytochrome P450 (CYP) 3A and CYP2D6. Besides P‐glycoprotein,…”
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Simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum and plasma using liquid chromatography–tandem mass spectrometry coupled with DAPTAD-derivatization by Gao, Chunying, Bergagnini-Kolev, Mackenzie C., Liao, Michael Z., Wang, Zhican, Wong, Timothy, Calamia, Justina C., Lin, Yvonne S., Mao, Qingcheng, Thummel, Kenneth E.

“…•A method for simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum or plasma was developed and…”
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Simultaneous quantification of 25-hydroxyvitamin D 3 -3-sulfate and 25-hydroxyvitamin D 3 -3-glucuronide in human serum and plasma using liquid chromatography-tandem mass spectrometry coupled with DAPTAD-derivatization by Gao, Chunying, Bergagnini-Kolev, Mackenzie C, Liao, Michael Z, Wang, Zhican, Wong, Timothy, Calamia, Justina C, Lin, Yvonne S, Mao, Qingcheng, Thummel, Kenneth E

“…25-hydroxyvitamin D -3-sulfate (25-OHD -S) and 25-hydroxyvitamin D -3-glucuronide (25-OHD -G) are major conjugative metabolites of vitamin D found in the…”
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Tacrolimus placental transfer at delivery and neonatal exposure through breast milk by Zheng, Songmao, Easterling, Thomas R., Hays, Karen, Umans, Jason G., Miodovnik, Menachem, Clark, Shannon, Calamia, Justina C., Thummel, Kenneth E., Shen, Danny D., Davis, Connie L., Hebert, Mary F.

“…Aim(s) The current investigation aims to provide new insights into fetal exposure to tacrolimus in utero by evaluating maternal and umbilical cord blood…”
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CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition by Zheng, Songmao, Tasnif, Yasar, Hebert, Mary F, Davis, Connie L, Shitara, Yoshihisa, Calamia, Justina C, Lin, Yvonne S, Shen, Danny D, Thummel, Kenneth E

“…Higher concentrations of AM19 and AM1c9, secondary metabolites of cyclosporine A (CsA), have been associated with nephrotoxicity in organ transplant patients…”
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CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition by Zheng, Songmao, Tasnif, Yasar, Hebert, Mary F., Davis, Connie L., Shitara, Yoshihisa, Calamia, Justina C., Lin, Yvonne S., Shen, Danny D., Thummel, Kenneth E.

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Transiently altered acetaminophen metabolism after liver transplantation by Park, Jeong M., Lin, Yvonne S., Calamia, Justina C., Thummel, Kenneth E., Slattery, John T., Kalhorn, Thomas F., Carithers, Robert L., Levy, Adam E., Marsh, Christopher L., Hebert, Mary F.

“…Background and objectives: Acetaminophen (INN, paracetamol) is metabolized to N‐acetyl‐p‐benzoquinone imine (NAPQI), a hepatotoxic metabolite, predominantly by…”
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Midazolam metabolism by modified Caco-2 monolayers: effects of extracellular protein binding by Fisher, J M, Wrighton, S A, Calamia, J C, Shen, D D, Kunze, K L, Thummel, K E

“…It has been suggested that the binding of a drug to plasma proteins will influence the intestinal extraction efficiency when drug is delivered to the mucosal…”
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CYP3A5 Gene Variation Influences both Systemic and Intrarenal Tacrolimus Disposition by Zheng, Songmao, Tasnif, Yasar, Hebert, Mary F., Davis, Connie L., Shitara, Yoshihisa, Calamia, Justina C., Lin, Yvonne S., Shen, Danny D., Thummel, Kenneth E.

“…We evaluated the hypothesis that CYP3A5 expression can affect intrarenal tacrolimus accumulation. An oral dose of tacrolimus was administered to 24 healthy…”
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Growth control in cultured 3T3 fibroblasts. III. Binding interactions of a growth inhibitory activity with target cells by Voss, P G, Steck, P A, Calamia, J C, Wang, J L

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