Search Results - "Calafate, Sara"

Loss of Bin1 Promotes the Propagation of Tau Pathology by Calafate, Sara, Flavin, William, Verstreken, Patrik, Moechars, Diederik

“…Tau pathology propagates within synaptically connected neuronal circuits, but the underlying mechanisms are unclear. BIN1-amphiphysin2 is the second most…”
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Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation by Calafate, Sara, Buist, Arjan, Miskiewicz, Katarzyna, Vijayan, Vinoy, Daneels, Guy, de Strooper, Bart, de Wit, Joris, Verstreken, Patrik, Moechars, Diederik

“…Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau pathology through the brain are common hallmarks of tauopathies,…”
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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism by Arranz, Amaia M, Delbroek, Lore, Van Kolen, Kristof, Guimarães, Marco R, Mandemakers, Wim, Daneels, Guy, Matta, Samer, Calafate, Sara, Shaban, Hamdy, Baatsen, Pieter, De Bock, Pieter-Jan, Gevaert, Kris, Vanden Berghe, Pieter, Verstreken, Patrik, De Strooper, Bart, Moechars, Diederik

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains…”
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Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques by Preman, Pranav, Tcw, Julia, Calafate, Sara, Snellinx, An, Alfonso-Triguero, Maria, Corthout, Nikky, Munck, Sebastian, Thal, Dietmar Rudolf, Goate, Alison M, De Strooper, Bart, Arranz, Amaia M

“…Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer's disease comes from…”
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The Dynamics and Turnover of Tau Aggregates in Cultured Cells by Guo, Jing L., Buist, Arjan, Soares, Alberto, Callaerts, Kathleen, Calafate, Sara, Stevenaert, Frederik, Daniels, Joshua P., Zoll, Bryan E., Crowe, Alex, Brunden, Kurt R., Moechars, Diederik, Lee, Virginia M.Y.

“…Filamentous tau aggregates, the hallmark lesions of Alzheimer disease (AD), play key roles in neurodegeneration. Activation of protein degradation systems has…”
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Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease by Calafate, Sara, Özturan, Gökhan, Thrupp, Nicola, Vanderlinden, Jeroen, Santa-Marinha, Luísa, Morais-Ribeiro, Rafaela, Ruggiero, Antonella, Bozic, Ivan, Rusterholz, Thomas, Lorente-Echeverría, Blanca, Dias, Marcelo, Chen, Wei-Ting, Fiers, Mark, Lu, Ashley, Vlaeminck, Ine, Creemers, Eline, Craessaerts, Katleen, Vandenbempt, Joris, van Boekholdt, Luuk, Poovathingal, Suresh, Davie, Kristofer, Thal, Dietmar Rudolf, Wierda, Keimpe, Oliveira, Tiago Gil, Slutsky, Inna, Adamantidis, Antoine, De Strooper, Bart, de Wit, Joris

“…Early Alzheimer’s disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently…”
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The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES by Guo, Jing L, Buist, Arjan, Soares, Alberto, Callaerts, Kathleen, Calafate, Sara, Stevenaert, Frederik, Daniels, Joshua P, Zoll, Bryan E, Crowe, Alex, Brunden, Kurt R, Moechars, Diederik, Lee, Virginia M Y

“…Filamentous tau aggregates, the hallmark lesions of Alzheimer disease (AD), play key roles in neurodegeneration. Activation of protein degradation systems has…”
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Chimeric models to analyze human neuron and astroglia responses in Alzheimer's disease: Molecular and cell biology/stem cells, iPS cells by Arranz, Amaia M., Preman, Pranav, T.C.W., Julia, Snellinx, An, Calafate, Sara, Thal, Dietmar Rudolf, Goate, Alison M., De Strooper, Bart

“…Abstract Background We have previously generated a chimeric model of Alzheimer´s disease (AD) by transplanting human pluripotent stem cell (PSC)‐derived…”
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Chimeric models to analyze human neuron and astroglia responses in Alzheimer's disease by Arranz, Amaia M., Preman, Pranav, T.C.W., Julia, Snellinx, An, Calafate, Sara, Thal, Dietmar Rudolf, Goate, Alison M., De Strooper, Bart

“…Background We have previously generated a chimeric model of Alzheimer´s disease (AD) by transplanting human pluripotent stem cell (PSC)‐derived neurons into…”
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Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-[beta] plaques by Preman, Pranav, TCW, Julia, Calafate, Sara, Snellinx, An, Alfonso-Triguero, Maria, Corthout, Nikky, Munck, Sebastian, Thal, Dietmar Rudolf, Goate, Alison M, De Strooper, Bart, Arranz, Amaia M

“…Background Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer's disease comes…”
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DOES LEUCINE-RICH REPEAT KINASE 2 MEDIATE ALPHA-SYNUCLEIN SEEDING VIA ITS ROLE IN ENDOCYTOSIS? by Delbroek, Lore, Van Kolen, Kristof, Arranz, Amaia, Daneels, Guy, Mandemakers, Wim, Calafate, Sara, Moechars, Diederik

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A importância do equilíbrio entre flexibilidade e estabilidade neuronal na formação de memórias by Calafate, Sara Cesariny

“…The neurobiological mechanisms behind memory formation remain unknown. Synapses are essential neuronal sub-compartments for the transmission of information…”
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P4‐025: DOES LEUCINE‐RICH REPEAT KINASE 2 MEDIATE ALPHA‐SYNUCLEIN SEEDING VIA ITS ROLE IN ENDOCYTOSIS? by Delbroek, Lore, Kolen, Kristof, Arranz, Amaia, Daneels, Guy, Mandemakers, Wim, Calafate, Sara, Moechars, Diederik

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Alguns contributos das Neurociências para a Educação: Os ambientes enriquecidos aumentam a capacidade de aprendizagem do nosso cérebro? by Calafate, Luís, Calafate, Sara

“…A reflexão e a discussão sobre o papel da especificação genética e da experiência na aquisição de uma função e no desenvolvimento de um indivíduo traduz um…”
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Tauopathy Seeding Models as a Platform for Tau Aggregation and Clearance Study by Calafate, Sara de Sa Cesariny

“…A doença de Alzheimer é a forma de demência mais prevalente. Quando a proteína Tau perde a conformação correcta forma agregados, começando por originar…”
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importância do equilíbrio entre flexibilidade e estabilidade neuronal na formação de memórias by Sara Cesariny Calafate

“…Os mecanismos neurobiológicos essenciais para a formação de memórias são ainda pouco compreendidos. No entanto, sabe-se que as sinapses, sub-compartimentos…”
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Alguns contributos das Neurociências para a Educação by Luís Calafate, Sara Cesariny Calafate

“…A reflexão e a discussão sobre o papel da especificação genética e da experiência na aquisição de uma função e no desenvolvimento de um indivíduo traduz um…”
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