Search Results - "Calabresi, Peter A"

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity by Kornberg, Michael D, Bhargava, Pavan, Kim, Paul M, Putluri, Vasanta, Snowman, Adele M, Putluri, Nagireddy, Calabresi, Peter A, Snyder, Solomon H

“…Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in…”
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A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis by Absinta, Martina, Maric, Dragan, Gharagozloo, Marjan, Garton, Thomas, Smith, Matthew D., Jin, Jing, Fitzgerald, Kathryn C., Song, Anya, Liu, Poching, Lin, Jing-Ping, Wu, Tianxia, Johnson, Kory R., McGavern, Dorian B., Schafer, Dorothy P., Calabresi, Peter A., Reich, Daniel S.

“…Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour ongoing demyelination and axon degeneration, and are identifiable in…”
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Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination by Kirby, Leslie, Jin, Jing, Cardona, Jaime Gonzalez, Smith, Matthew D., Martin, Kyle A., Wang, Jingya, Strasburger, Hayley, Herbst, Leyla, Alexis, Maya, Karnell, Jodi, Davidson, Todd, Dutta, Ranjan, Goverman, Joan, Bergles, Dwight, Calabresi, Peter A.

“…Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin…”
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Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis by Petzold, Axel, Dr, de Boer, Johannes F, Prof, Schippling, Sven, MD, Vermersch, Patrik, Prof, Kardon, Randy, Prof, Green, Ari, MD, Calabresi, Peter A, Prof, Polman, Chris, Prof

“…Summary Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the…”
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DeepHarmony: A deep learning approach to contrast harmonization across scanner changes by Dewey, Blake E., Zhao, Can, Reinhold, Jacob C., Carass, Aaron, Fitzgerald, Kathryn C., Sotirchos, Elias S., Saidha, Shiv, Oh, Jiwon, Pham, Dzung L., Calabresi, Peter A., van Zijl, Peter C.M., Prince, Jerry L.

“…Magnetic resonance imaging (MRI) is a flexible medical imaging modality that often lacks reproducibility between protocols and scanners. It has been shown that…”
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Synaptic and complement markers in extracellular vesicles in multiple sclerosis by Bhargava, Pavan, Nogueras-Ortiz, Carlos, Kim, Sol, Delgado-Peraza, Francheska, Calabresi, Peter A, Kapogiannis, Dimitrios

“…Background: Synaptic loss is a feature of multiple sclerosis pathology that can be seen even in normal-appearing gray matter. Opsonization of synapses with…”
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Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior by Linville, Raleigh M., DeStefano, Jackson G., Sklar, Matt B., Xu, Zinnia, Farrell, Alanna M., Bogorad, Max I., Chu, Chengyan, Walczak, Piotr, Cheng, Linzhao, Mahairaki, Vasiliki, Whartenby, Katharine A., Calabresi, Peter A., Searson, Peter C.

“…Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major…”
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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial by Calabresi, Peter A, Dr, Radue, Ernst-Wilhelm, Prof, Goodin, Douglas, MD, Jeffery, Douglas, MD, Rammohan, Kottil W, MD, Reder, Anthony T, MD, Vollmer, Timothy, MD, Agius, Mark A, MD, Kappos, Ludwig, Prof, Stites, Tracy, PhD, Li, Bingbing, PhD, Cappiello, Linda, MD, von Rosenstiel, Philipp, MD, Lublin, Fred D, MD

“…Summary Background Fingolimod has shown reductions in clinical and MRI disease activity in patients with relapsing-remitting multiple sclerosis. We further…”
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Structured layer surface segmentation for retina OCT using fully convolutional regression networks by He, Yufan, Carass, Aaron, Liu, Yihao, Jedynak, Bruno M., Solomon, Sharon D., Saidha, Shiv, Calabresi, Peter A., Prince, Jerry L.

“…•A novel formulation of deep network to output continuous, smooth and topology correct surfaces without post-processing.•End-to-end optimization of multiple…”
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Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition by Bhargava, Pavan, Kim, Sol, Reyes, Arthur A, Grenningloh, Roland, Boschert, Ursula, Absinta, Martina, Pardo, Carlos, Zijl, Peter Van, Zhang, Jiangyang, Calabresi, Peter A

“…Leptomeningeal inflammation in multiple sclerosis is associated with worse clinical outcomes and greater cortical pathology. Despite progress in identifying…”
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Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study by Calabresi, Peter A, Prof, Kieseier, Bernd C, MD, Arnold, Douglas L, Prof, Balcer, Laura J, Prof, Boyko, Alexey, Prof, Pelletier, Jean, MD, Liu, Shifang, PhD, Zhu, Ying, PhD, Seddighzadeh, Ali, MD, Hung, Serena, MD, Deykin, Aaron, MD

“…Summary Background Subcutaneous pegylated interferon (peginterferon) beta-1a is being developed for treatment of relapsing multiple sclerosis, with less…”
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Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein by Johnson, Tory P., Patel, Karan, Johnson, Kory R., Marie, Dragan, Maric, Dragan, Calabresi, Peter A., Hasbun, Rodrigo, Nath, Avindra

“…Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV infection and can cause a devastating immune reconstitution…”
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PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R) by Horti, Andrew G., Naik, Ravi, Foss, Catherine A., Minn, Il, Misheneva, Varia, Du, Yong, Wang, Yuchuan, Mathews, William B., Wu, Yunkou, Hall, Andrew, LaCourse, Catherine, Ahn, Hye-Hyun, Nam, Hwanhee, Lesniak, Wojciech G., Valentine, Heather, Pletnikova, Olga, Troncoso, Juan C., Smith, Matthew D., Calabresi, Peter A., Savonenko, Alena V., Dannals, Robert F., Pletnikov, Mikhail V., Pomper, Martin G.

“…While neuroinflammation is an evolving concept and the cells involved and their functions are being defined, microglia are understood to be a key cellular…”
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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial by Kappos, Ludwig, Prof, Li, David, MD, Calabresi, Peter A, MD, O'Connor, Paul, MD, Bar-Or, Amit, MD, Barkhof, Frederik, Prof, Yin, Ming, PhD, Leppert, David, MD, Glanzman, Robert, MD, Tinbergen, Jeroen, MD, Hauser, Stephen L, Prof

“…Summary Background B lymphocytes are implicated in the pathogenesis of multiple sclerosis. We aimed to assess efficacy and safety of two dose regimens of the…”
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Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis by Sotirchos, Elias S, Bhargava, Pavan, Eckstein, Christopher, Van Haren, Keith, Baynes, Moira, Ntranos, Achilles, Gocke, Anne, Steinman, Lawrence, Mowry, Ellen M, Calabresi, Peter A

“…OBJECTIVE:To study the safety profile and characterize the immunologic effects of high- vs low-dose cholecalciferol supplementation in patients with multiple…”
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Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study by Martinez-Lapiscina, Elena H, MD, Arnow, Sam, BS, Wilson, James A, BS, Saidha, Shiv, MD, Preiningerova, Jana Lizrova, MD, Oberwahrenbrock, Timm, MD, Brandt, Alexander U, MD, Pablo, Luis E, MD, Guerrieri, Simone, MD, Gonzalez, Ines, MD, Outteryck, Olivier, MD, Mueller, Ann-Kristin, BS, Albrecht, Phillip, MD, Chan, Wesley, BS, Lukas, Sebastian, BS, Balk, Lisanne J, PhD, Fraser, Clare, MD, Frederiksen, Jette L, Prof, Resto, Jennifer, BS, Frohman, Teresa, MD, Cordano, Christian, MD, Zubizarreta, Irati, MD, Andorra, Magi, BSc, Sanchez-Dalmau, Bernardo, MD, Saiz, Albert, MD, Bermel, Robert, MD, Klistorner, Alexander, PhD, Petzold, Axel, MD, Schippling, Sven, MD, Costello, Fiona, MD, Aktas, Orhan, Prof, Vermersch, Patrick, Prof, Oreja-Guevara, Celia, MD, Comi, Giancarlo, Prof, Leocani, Letizia, MD, Garcia-Martin, Elena, MD, Paul, Friedemann, Prof, Havrdova, Eva, MD, Frohman, Elliot, Prof, Balcer, Laura J, Prof, Green, Ari J, MD, Calabresi, Peter A, Prof, Villoslada, Pablo, Prof

“…Summary Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the…”
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AQP4-IgG and MOG-IgG Related Optic Neuritis—Prevalence, Optical Coherence Tomography Findings, and Visual Outcomes: A Systematic Review and Meta-Analysis by Filippatou, Angeliki G., Mukharesh, Loulwah, Saidha, Shiv, Calabresi, Peter A., Sotirchos, Elias S.

“…Background: Optic neuritis (ON) is a cardinal manifestation of multiple sclerosis (MS), aquaporin-4 (AQP4)-IgG-, and myelin oligodendrocyte glycoprotein…”
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Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study by Saidha, Shiv, Dr, Sotirchos, Elias S, MD, Ibrahim, Mohamed A, MD, Crainiceanu, Ciprian M, PhD, Gelfand, Jeffrey M, MD, Sepah, Yasir J, MBBS, Ratchford, John N, MD, Oh, Jiwon, FRCPC, Seigo, Michaela A, ScB, Newsome, Scott D, DO, Balcer, Laura J, Prof, Frohman, Elliot M, Prof, Green, Ari J, MD, Nguyen, Quan D, MD, Calabresi, Peter A, Prof

“…Summary Background Microcystic macular oedema (MMO) of the retinal inner nuclear layer (INL) has been identified in patients with multiple sclerosis (MS) by…”
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Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis by Gharagozloo, Marjan, Mace, Jackson W., Calabresi, Peter A.

“…Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS,…”
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Remyelination alters the pattern of myelin in the cerebral cortex by Orthmann-Murphy, Jennifer, Call, Cody L, Molina-Castro, Gian C, Hsieh, Yu Chen, Rasband, Matthew N, Calabresi, Peter A, Bergles, Dwight E

“…Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with cognitive disability in…”
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