Search Results - "Calabrese, Roberta"

Reconfiguration of DNA methylation in aging by Zampieri, Michele, Ciccarone, Fabio, Calabrese, Roberta, Franceschi, Claudio, Bürkle, Alexander, Caiafa, Paola

“…•Methylated cytosines have a non-random distribution throughout the genome.•DNA methylation patterns are dynamic states balanced by methylation and…”
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Primordial black hole dark matter evaporating on the neutrino floor by Calabrese, Roberta, Fiorillo, Damiano F.G., Miele, Gennaro, Morisi, Stefano, Palazzo, Antonio

“…Primordial black holes (PBHs) hypothetically generated in the first instants of life of the Universe are potential dark matter (DM) candidates. Focusing on…”
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ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites by Zampieri, Michele, Guastafierro, Tiziana, Calabrese, Roberta, Ciccarone, Fabio, Bacalini, Maria G, Reale, Anna, Perilli, Mariagrazia, Passananti, Claudio, Caiafa, Paola

“…PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dnmt1 [DNA…”
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Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles by Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola

“…Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA…”
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Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide by Tentori, Lucio, Ricci-Vitiani, Lucia, Muzi, Alessia, Ciccarone, Fabio, Pelacchi, Federica, Calabrese, Roberta, Runci, Daniele, Pallini, Roberto, Caiafa, Paola, Graziani, Grazia

“…Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM…”
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Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity by Zampieri, Michele, Passananti, Claudio, Calabrese, Roberta, Perilli, Mariagrazia, Corbi, Nicoletta, De Cave, Fabiana, Guastafierro, Tiziana, Bacalini, Maria Giulia, Reale, Anna, Amicosante, Gianfranco, Calabrese, Lilia, Zlatanova, Jordanka, Caiafa, Paola

“…Aberrant hypermethylation of CpG islands in housekeeping gene promoters and widespread genome hypomethylation are typical events occurring in cancer cells. The…”
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Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study by Valentini, Elisabetta, Zampieri, Michele, Malavolta, Marco, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Hervonen, Antti, Koller, Bernhard, Bernhardt, Jürgen, Slagboom, P Eline, Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S, Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn E T, Moreno-Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Ciccarone, Fabio, Caiafa, Paola

“…Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC),…”
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Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial by Lanfranconi, Silvia, Scola, Elisa, Meessen, Jennifer M T A, Pallini, Roberto, Bertani, Giulio A, Al-Shahi Salman, Rustam, Dejana, Elisabetta, Latini, Roberto

“…Observations in people with cerebral cavernous malformations, and in preclinical models of this disorder, suggest that the β-blocker propranolol might reduce…”
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Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood by Calabrese, Roberta, Zampieri, Michele, Mechelli, Rosella, Annibali, Viviana, Guastafierro, Tiziana, Ciccarone, Fabio, Coarelli, Giulia, Umeton, Renato, Salvetti, Marco, Caiafa, Paola

“…Background: Peptidylarginine deiminase 2 (PAD2) and peptidylarginine deiminase 4 (PAD4) are two members of PAD family which are over-expressed in the multiple…”
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Age‐dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK‐AGE study by Ciccarone, Fabio, Malavolta, Marco, Calabrese, Roberta, Guastafierro, Tiziana, Bacalini, Maria Giulia, Reale, Anna, Franceschi, Claudio, Capri, Miriam, Hervonen, Antti, Hurme, Mikko, Grubeck‐Loebenstein, Beatrix, Koller, Bernhard, Bernhardt, Jürgen, Schӧn, Christiane, Slagboom, P. Eline, Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn, Moreno‐Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Zampieri, Michele, Caiafa, Paola

“…Summary Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these…”
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PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression by Mariano, Germano, Ricciardi, Maria Rosaria, Trisciuoglio, Daniela, Zampieri, Michele, Ciccarone, Fabio, Guastafierro, Tiziana, Calabrese, Roberta, Valentini, Elisabetta, Tafuri, Agostino, Del Bufalo, Donatella, Caiafa, Paola, Reale, Anna

“…To overcome cancer cells resistance to pharmacological therapy, the development of new therapeutic approaches becomes urgent. For this purpose, the use of…”
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Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription by Ciccarone, Fabio, Valentini, Elisabetta, Bacalini, Maria Giulia, Zampieri, Michele, Calabrese, Roberta, Guastafierro, Tiziana, Mariano, Germano, Reale, Anna, Franceschi, Claudio, Caiafa, Paola

“…TET enzymes are the epigenetic factors involved in the formation of the sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with…”
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DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project by Ciccarone, Fabio, Valentini, Elisabetta, Malavolta, Marco, Zampieri, Michele, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Capri, Miriam, Breusing, Nicolle, Grune, Tilman, Moreno-Villanueva, María, Bürkle, Alexander, Caiafa, Paola

“…Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically…”
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Circulating biomarkers in familial cerebral cavernous malformation by Lazzaroni, Francesca, Meessen, Jennifer M.T.A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolò M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Rödel, Claudia J., Rezai Jahromi, Behnam, Bolli, Niccolò, Passamonti, Francesco, Magnusson, Peetra U., Abdelilah-Seyfried, Salim, Dejana, Elisabetta, Latini, Roberto

“…Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in…”
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ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement(1) by Guastafierro, Tiziana, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Martella, Oliviano, Bacalini, Maria Giulia, Reale, Anna, Di Girolamo, Maria, Miccheli, Margherita, Farrar, Dawn, Klenova, Elena, Ciccarone, Fabio, Caiafa, Paola

“…Ctcf (CCCTC-binding factor) directly induces Parp [poly(ADP-ribose) polymerase] 1 activity and its PARylation [poly(ADPribosyl)ation] in the absence of DNA…”
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Circulating biomarkers in familial cerebral cavernous malformationResearch in context by Francesca Lazzaroni, Jennifer M.T.A. Meessen, Ying Sun, Silvia Lanfranconi, Elisa Scola, Quintino Giorgio D'Alessandris, Laura Tassi, Maria Rita Carriero, Marco Castori, Silvia Marino, Adriana Blanda, Enrico B. Nicolis, Deborah Novelli, Roberta Calabrese, Nicolò M. Agnelli, Barbara Bottazzi, Roberto Leone, Selene Mazzola, Silvia Besana, Carlotta Catozzi, Luigi Nezi, Maria G. Lampugnani, Matteo Malinverno, Nastasja Grdseloff, Claudia J. Rödel, Behnam Rezai Jahromi, Niccolò Bolli, Francesco Passamonti, Peetra U. Magnusson, Salim Abdelilah-Seyfried, Elisabetta Dejana, Roberto Latini

“…Background: Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may…”
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Poly by Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola

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Poly by Calabrese, Roberta, Catizone, Angela, Zampieri, Michele, Ciccarone, Fabio, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola, Klinger, Francesca Gioia

“…Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA…”
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Polyation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles by Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola

“…Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA…”
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Poly by Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola

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