Non-invasive follicular neoplasm with papillary-like nuclear features: a challenging and infrequent entity in Argentina

Purpose Non-invasive encapsulated follicular variant of papillary thyroid cancer was reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These neoplasms have an extremely low malignant potential. The aim of this study was (1) to assess the prevalenc...

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Published in:Endocrine Vol. 77; no. 3; pp. 493 - 499
Main Authors: Sabán, Melina, Tolaba, Norma, Orlandi, Ana María, Deutsch, Susana, Pitoia, Fabián, Lowenstein, Alicia, Calabrese, María Cristina, Cavallo, Andrea, Iotti, Alejandro, Monteros Alvi, Marcelo, Nallar, Marcelo, Jaén, Ana, Figurelli, Silvina, Carrizo, Fernando, Colobraro, Antonio, García Tascón, Gabriela, Saccoliti, María, Paes de Lima, Andrea, Lencioni, Melisa, Califano, Inés, Cabezón, Carmen
Format: Journal Article
Language:English
Published: New York Springer US 01-09-2022
Springer Nature B.V
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Summary:Purpose Non-invasive encapsulated follicular variant of papillary thyroid cancer was reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These neoplasms have an extremely low malignant potential. The aim of this study was (1) to assess the prevalence of NIFTP in patients with papillary thyroid carcinoma, (2) to evaluate their outcomes, and (3) to determine their molecular profile. Methods Multicenter, descriptive, retrospective study. Patients with papillary thyroid cancer diagnosed from January 2006 to December 2016 from 11 referral centers were included. Diagnosis of NIFTP was based on criteria described by Nikiforov et al. in 2018. At least two pathologists agreed on the diagnosis. Two thousand six hundred and seventy-seven papillary thyroid cancer patients were included; 456 (17%) of them were follicular variant papillary thyroid cancer, and 30 (1.12%) fulfilled diagnostic criteria for NIFTP. Results Each of the 30 included patients underwent a total thyroidectomy, and 50% were treated with radioiodine (median dose 100 mCi). After a median follow-up of 37 months, 84% of patients had an excellent response, 3% had an indeterminate response and data was missing in the remaining 13%. No metastatic lymph nodes, distant metastases or recurrences were found. RAS mutations were detected in 4 patients (13%). Conclusion The prevalence of NIFTP in our series is amongst the lowest reported. Excellent outcomes of patients underscore their low malignant potential. Molecular findings differ from other series, probably related to environmental or ethnic features of our population and the meticulous criteria for diagnosing NIFTP.
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ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03115-7