Search Results - "Cala, Steven E."

Activation of Ca2+ transport in cardiac microsomes enriches functional sets of ER and SR proteins by Cala, Steven E., Carruthers, Nicholas J., Stemmer, Paul M., Chen, Zhenhui, Chen, Xuequn

“…The importance of sarcoplasmic reticulum (SR) Ca 2+ -handling in heart has led to detailed understanding of Ca 2+ -release and re-uptake protein complexes,…”
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Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling by Wu, Adonis Z., PhD, Xu, Dongzhu, MD, PhD, Yang, Na, MD, Lin, Shien-Fong, PhD, Chen, Peng-Sheng, MD, Cala, Steven E., PhD, Chen, Zhenhui, PhD

“…Abstract Aims Phospholamban (PLB) regulates the cardiac Ca 2 + -ATPase (SERCA2a) in sarcoplasmic reticulum (SR). However, the localization of PLB at…”
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Calsequestrin Accumulation in Rough Endoplasmic Reticulum Promotes Perinuclear Ca2+ Release by Guo, Ang, Cala, Steven E., Song, Long-Sheng

“…Molecular mechanisms underlying Ca2+ regulation by perinuclear endoplasmic/sarcoplasmic reticulum (ER/SR) cisternae in cardiomyocytes remain obscure. To…”
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Rough endoplasmic reticulum to junctional sarcoplasmic reticulum trafficking of calsequestrin in adult cardiomyocytes by McFarland, Timothy P, Milstein, Michelle L, Cala, Steven E

“…Abstract Cardiac calsequestrin (CSQ) is synthesized on rough endoplasmic reticulum (ER), but concentrates within the junctional sarcoplasmic reticulum (SR)…”
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Transitions of protein traffic from cardiac ER to junctional SR by Sleiman, Naama H, McFarland, Timothy P, Jones, Larry R, Cala, Steven E

“…Abstract The junctional sarcoplasmic reticulum (jSR) is an important and unique ER subdomain in the adult myocyte that concentrates resident proteins to…”
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Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool by He, Wenbo, Huang, Dayang, Guo, Shuai, Wang, Danning, Guo, Jin, Cala, Steven E., Chen, Zhenhui

“…Phospholamban (PLB) stoichiometrically regulates the cardiac Ca2+ pump (SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of…”
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Inefficient Glycosylation Leads to High Steady-state Levels of Actively Degrading Cardiac Triadin-1 by Milstein, Michelle L., McFarland, Timothy P., Marsh, James D., Cala, Steven E.

“…In junctional sarcoplasmic reticulum, binding to cardiac triadin-1 provides a mechanism by which the Ca2+-release channel/ryanodine receptor may link with…”
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Depressed PKA Activity Contributes to Impaired SERCA Function and is Linked to the Pathogenesis of Glucose-induced Cardiomyopathy by Dutta, Kaushik, Carmody, Marybeth W., Cala, Steven E., Davidoff, Amy J.

“…K. Dutta, M. W. Carmody, S. E. Cala and A. J. Davidoff. Depressed PKA Activity Contributes to Impaired SERCA Function and is Linked to the Pathogenesis of…”
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GRP94 hyperglycosylation and phosphorylation in Sf21 cells by Cala, Steven E

“…GRP94 is an inducible resident endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) glycoprotein that functions as a protein chaperone and Ca 2+ regulator…”
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Mass Spectrometry of Cardiac Calsequestrin Characterizes Microheterogeneity Unique to Heart and Indicative of Complex Intracellular Transit by O'Brian, Jeffrey J., Ram, Michal L., Kiarash, Arash, Cala, Steven E.

“…Cardiac calsequestrin concentrates in junctional sarcoplasmic reticulum in heart and skeletal muscle cells by an undefined mechanism. During transit through…”
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Unitary anion currents through phospholemman channel molecules by Moorman, J. Randall, Ackerman, Stephen J, Kowdley, Gopal C, Griffin, M. Pamela, Mounsey, J. Paul, Chen, Zhenhui, Cala, Steven E, O'Brian, Jeffrey J, Szabo, Gabor, Jones, Larry R

“…Phospholemman (PLM) is a 72-amino-acid peptide with a single transmembrane domain, the expression of which induces chloride currents in Xenopus oocytes. It has…”
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Calsequestrin isoforms localize to different ER subcompartments: Evidence for polymer and heteropolymer-dependent localization by Milstein, Michelle L., Houle, Timothy D., Cala, Steven E.

“…Skeletal muscle calsequestrin (skelCSQ) and cardiac calsequestrin (cardCSQ) are resident proteins of the ER/SR, but mechanisms by which CSQ is retained inside…”
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Altered calsequestrin glycan processing is common to diverse models of canine heart failure by Jacob, Sony, Sleiman, Naama H., Kern, Stephanie, Jones, Larry R., Sala-Mercado, Javier A., McFarland, Timothy P., Sabbah, Hani H., Cala, Steven E.

“…Calsequestrin-2 (CSQ2) is a resident glycoprotein of junctional sarcoplasmic reticulum that functions in the regulation of SR Ca 2+ release. CSQ2 is…”
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Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats by Wold, Loren E., Dutta, Kaushik, Mason, Meredith M., Ren, Jun, Cala, Steven E., Schwanke, Mary L., Davidoff, Amy J.

“…Ventricular dysfunction in type 2 diabetic patients is becoming apparent early after diagnosis of diabetes, but the cellular mechanisms contributing to this…”
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The cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells by McFarland, Timothy P., Sleiman, Naama H., Yaeger, Daniel B., Cala, Steven E.

“…The luminal SR protein CSQ2 contains phosphate on roughly half of the serines found in its C-terminus. The sequence around phosphorylation sites in CSQ2…”
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Triadin Overexpression Stimulates Excitation-Contraction Coupling and Increases Predisposition to Cellular Arrhythmia in Cardiac Myocytes by Terentyev, Dmitry, Cala, Steven E, Houle, Timothy D, Viatchenko-Karpinski, Serge, Gyorke, Inna, Terentyeva, Radmila, Williams, Simon C, Gyorke, Sandor

“…Triadin 1 (TRD) is an integral membrane protein that associates with the ryanodine receptor (RyR2), calsequestrin (CASQ2) and junctin to form a macromolecular…”
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Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium by HOULE, Timothy D, RAM, Michal L, CALA, Steven E

“…A point mutation in human cardiac calsequestrin (CSQ-D307H) is responsible for a form of polymorphic ventricular tachycardia (PVT). When overexpressed in heart…”
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Different endoplasmic reticulum trafficking and processing pathways for calsequestrin (CSQ) and epitope-tagged CSQ by Houle, Timothy D., Ram, Michal L., McMurray, Walter J., Cala, Steven E.

“…Cardiac calsequestrin (CSQ) is a protein that traffics to and concentrates inside sarcoplasmic reticulum (SR) terminal cisternae, a protein secretory…”
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Defective glycosylation of calsequestrin in heart failure by KIARASH, Arash, KELLY, Carmen E, PHINNEY, Brett S, VALDIVIA, Héctor H, ABRAMS, Judith, CALA, Steven E

“…Levels of Ca2+ regulatory proteins have been extensively analyzed in cardiomyopathies as possible indices of change in sarcoplasmic reticulum (SR) structure…”
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Phospholemman expression is high in the newborn rabbit heart and declines with postnatal maturation by Srivastava, Shekhar, Cala, Steven E., Coetzee, William A., Artman, Michael

“…Phospholemman (PLM) is a small sarcolemmal protein that modulates the activities of Na +/K +-ATPase and the Na +/Ca 2+ exchanger (NCX), thus contributing to…”
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