Search Results - "Cajal, Y."

Clinical implications of intratumor heterogeneity: challenges and opportunities by Ramón y Cajal, Santiago, Sesé, Marta, Capdevila, Claudia, Aasen, Trond, De Mattos-Arruda, Leticia, Diaz-Cano, Salvador J., Hernández-Losa, Javier, Castellví, Josep

“…In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral…”
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ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells by Fuentes, Pedro, Sesé, Marta, Guijarro, Pedro J., Emperador, Marta, Sánchez-Redondo, Sara, Peinado, Héctor, Hümmer, Stefan, Ramón y Cajal, Santiago

“…Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously…”
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STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis by Priego, Neibla, Zhu, Lucía, Monteiro, Cátia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martínez, Liliana, Martínez-Saez, Elena, Ramón y Cajal, Santiago, Megías, Diego, Hernández-Encinas, Elena, Blanco-Aparicio, Carmen, Martínez, Lola, Zarzuela, Eduardo, Muñoz, Javier, Fustero-Torre, Coral, Piñeiro-Yáñez, Elena, Hernández-Laín, Aurelio, Bertero, Luca, Poli, Valeria, Sanchez-Martinez, Melchor, Menendez, Javier A., Soffietti, Riccardo, Bosch-Barrera, Joaquim, Valiente, Manuel

“…The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control…”
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Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils by Robichaud, Nathaniel, Hsu, Brian E., Istomine, Roman, Alvarez, Fernando, Blagih, Julianna, Ma, Eric H., Morales, Sebastian V., Dai, David L., Li, Glenn, Souleimanova, Margarita, Guo, Qianyu, del Rincon, Sonia V., Miller, Wilson H., Cajal, Santiago Ramón y, Park, Morag, Jones, Russell G., Piccirillo, Ciriaco A., Siegel, Peter M., Sonenberg, Nahum

“…The translation of mRNAs into proteins serves as a critical regulatory event in gene expression. In the context of cancer, deregulated translation is a…”
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Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid by Martínez-Ricarte, Francisco, Mayor, Regina, Martínez-Sáez, Elena, Rubio-Pérez, Carlota, Pineda, Estela, Cordero, Esteban, Cicuéndez, Marta, Poca, Maria A, López-Bigas, Nuria, Ramon Y Cajal, Santiago, Vieito, María, Carles, Joan, Tabernero, Josep, Vivancos, Ana, Gallego, Soledad, Graus, Francesc, Sahuquillo, Juan, Seoane, Joan

“…Diffuse gliomas are the most common primary tumor of the brain and include different subtypes with diverse prognosis. The genomic characterization of diffuse…”
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Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma by Escudero, Laura, Llort, Anna, Arias, Alexandra, Diaz-Navarro, Ander, Martínez-Ricarte, Francisco, Rubio-Perez, Carlota, Mayor, Regina, Caratù, Ginevra, Martínez-Sáez, Elena, Vázquez-Méndez, Élida, Lesende-Rodríguez, Iván, Hladun, Raquel, Gros, Luis, Ramón y Cajal, Santiago, Poca, Maria A., Puente, Xose S., Sahuquillo, Juan, Gallego, Soledad, Seoane, Joan

“…The molecular characterisation of medulloblastoma, the most common paediatric brain tumour, is crucial for the correct management and treatment of this…”
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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer by Tenbaum, Stephan P, Ordóñez-Morán, Paloma, Puig, Isabel, Chicote, Irene, Arqués, Oriol, Landolfi, Stefania, Fernández, Yolanda, Herance, José Raúl, Gispert, Juan D, Mendizabal, Leire, Aguilar, Susana, Cajal, Santiago Ramón y, Schwartz, Simó, Vivancos, Ana, Espín, Eloy, Rojas, Santiago, Baselga, José, Tabernero, Josep, Muñoz, Alberto, Palmer, Héctor G

“…The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through…”
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Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity by Scaltriti, M, Verma, C, Guzman, M, Jimenez, J, Parra, J L, Pedersen, K, Smith, D J, Landolfi, S, Ramon y Cajal, S, Arribas, J, Baselga, J

“…Lapatinib is a human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitor (TKI) that has clinical activity in HER2-amplified breast cancer. In…”
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p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors by Romagosa, C, Simonetti, S, López-Vicente, L, Mazo, A, Lleonart, M E, Castellvi, J, Ramon y Cajal, S

“…p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological…”
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Expression of p95HER2, a Truncated Form of the HER2 Receptor, and Response to Anti-HER2 Therapies in Breast Cancer by Scaltriti, Maurizio, Rojo, Federico, Ocaña, Alberto, Anido, Judit, Guzman, Marta, Cortes, Javier, Di Cosimo, Serena, Matias-Guiu, Xavier, Ramon y Cajal, Santiago, Arribas, Joaquin, Baselga, José

“…Background Women with HER2–overexpressing breast cancers have poor prognosis, and many are resistant to the HER2 monoclonal antibody trastuzumab. A subgroup of…”
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Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors by TABERNERO, Josep, ROJO, Federico, SHAND, Nicholas, MACARULLA, Teresa, RAMOS, Francisco Javier, DIMITRIJEVIC, Sasa, ZOELLNER, Ulrike, TANG, Pui, STUMM, Michael, LANE, Heidi A, LEBWOHL, David, BASELGA, José, CALVO, Emiliano, BURNS, Howard, JUDSON, Ian, HAZELL, Katharine, MARTINELLI, Erika, Y CAJAL, Santiago Ramon, JONES, Suzanne, VIDAL, Laura

“…Everolimus is a selective mammalian target of rapamycin (mTOR) inhibitor with promising anticancer activity. In order to identify a rationally based dose and…”
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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer by Bullman, Susan, Pedamallu, Chandra S., Sicinska, Ewa, Clancy, Thomas E., Zhang, Xiaoyang, Cai, Diana, Neuberg, Donna, Huang, Katherine, Guevara, Fatima, Nelson, Timothy, Chipashvili, Otari, Hagan, Timothy, Walker, Mark, Ramachandran, Aruna, Diosdado, Begoña, Serna, Garazi, Mulet, Nuria, Landolfi, Stefania, Ramon y Cajal, Santiago, Fasani, Roberta, Aguirre, Andrew J., Ng, Kimmie, Élez, Elena, Ogino, Shuji, Tabernero, Josep, Fuchs, Charles S., Hahn, William C., Nuciforo, Paolo, Meyerson, Matthew

“…Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent…”
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Peripheral and lung resident memory T cell responses against SARS-CoV-2 by Grau-Expósito, Judith, Sánchez-Gaona, Nerea, Massana, Núria, Suppi, Marina, Astorga-Gamaza, Antonio, Perea, David, Rosado, Joel, Falcó, Anna, Kirkegaard, Cristina, Torrella, Ariadna, Planas, Bibiana, Navarro, Jordi, Suanzes, Paula, Álvarez-Sierra, Daniel, Ayora, Alfonso, Sansano, Irene, Esperalba, Juliana, Andrés, Cristina, Antón, Andrés, Ramón y Cajal, Santiago, Almirante, Benito, Pujol-Borrell, Ricardo, Falcó, Vicenç, Burgos, Joaquín, Buzón, María J., Genescà, Meritxell

“…Resident memory T cells (T RM ) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T RM are…”
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Beyond molecular tumor heterogeneity: protein synthesis takes control by Ramon y Cajal, Santiago, Castellvi, Josep, Hümmer, Stefan, Peg, Vicente, Pelletier, Jerry, Sonenberg, Nahum

“…One of the daunting challenges facing modern medicine lies in the understanding and treatment of tumor heterogeneity. Most tumors show intra-tumor…”
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Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma by De Mattos-Arruda, Leticia, Mayor, Regina, Ng, Charlotte K. Y., Weigelt, Britta, Martínez-Ricarte, Francisco, Torrejon, Davis, Oliveira, Mafalda, Arias, Alexandra, Raventos, Carolina, Tang, Jiabin, Guerini-Rocco, Elena, Martínez-Sáez, Elena, Lois, Sergio, Marín, Oscar, de la Cruz, Xavier, Piscuoglio, Salvatore, Towers, Russel, Vivancos, Ana, Peg, Vicente, Ramon y Cajal, Santiago, Carles, Joan, Rodon, Jordi, González-Cao, María, Tabernero, Josep, Felip, Enriqueta, Sahuquillo, Joan, Berger, Michael F., Cortes, Javier, Reis-Filho, Jorge S., Seoane, Joan

“…Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor…”
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Cervical carcinosarcoma, report of some cases and a literature review by Mariño‐Noya, Alejandra, Magallanes‐Peláez, Nadia, Puga‐González, Nerea, Conde‐Ferreirós, Marta, Vieitez‐Villaverde, María D., López‐Ramón y Cajal, Carlos N.

“…Synopsis Most data come from case series, so diagnosis and management may pose a challenge. Further investigations are needed to determine HPV's role in this…”
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A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and Metastasis by Pedersen, Kim, Angelini, Pier-Davide, Laos, Sirle, Bach-Faig, Alba, Cunningham, Matthew P, Ferrer-Ramón, Cristina, Luque-García, Antonio, García-Castillo, Jesús, Parra-Palau, Josep Lluis, Scaltriti, Maurizio, Ramón y Cajal, Santiago, Baselga, José, Arribas, Joaquín

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9 by Feliciano, Andrea, Castellvi, Josep, Artero-Castro, Ana, Leal, Jose A, Romagosa, Cleofé, Hernández-Losa, Javier, Peg, Vicente, Fabra, Angels, Vidal, Francisco, Kondoh, Hiroshi, Ramón Y Cajal, Santiago, Lleonart, Matilde E

“…MicroRNAs (miRNAs) play important roles in diverse biological processes and are emerging as key regulators of tumorigenesis and tumor progression. To explore…”
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Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells by Tishchenko, Alexander, Azorín, Daniel D, Vidal-Brime, Laia, Muñoz, María José, Arenas, Pol Jiménez, Pearce, Christopher, Girao, Henrique, Ramón Y Cajal, Santiago, Aasen, Trond

“…Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both…”
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Antenatal study of the Heschl’s gyrus: The first step to understanding prenatal learning by López Ramón y Cajal, C.

“…We located Heschl’s gyrus (HG) in utero during antenatal development. The antenatal location of the HG will allow us to evaluate adaptations of the human…”
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