Calophyllum brasiliense Modulates the Immune Response and Promotes Leishmania amazonensis Intracellular Death

Calophyllum brasiliense Modulates the Immune Response and Promotes Leishmania amazonensis Intracellular Death

Calophyllum brasiliense is a plant from the Brazilian rain forests and has been used in folk medicine for the treatment of various diseases, including leishmaniasis. This infectious disease depends on the Leishmania sp. and the host immune response. C. brasiliense antileishmanial activity is well kn...

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Bibliographic Details
Published in:Mediators of inflammation Vol. 2018; no. 2018; pp. 1 - 9
Main Authors: Silveira, Thaís Gomes Verziganassi, Pedroso, Raissa Bocchi, Caitano, J. Z., Demarchi, Izabel Galhardo, Domeneghetti, L., Lonardoni, Maria Valdrinez Campana
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Animals
Apoptosis
Brazil
Calophyllum
Calophyllum - chemistry
Cytokines
Female
Folk medicine
Gene expression
Gene therapy
Health aspects
IL-1β
Immune response
Immunology
Immunomodulation
Infection
Infections
Infectious diseases
Inflammation
Interleukin 10
Interleukin 18
Interleukin-10 - metabolism
Interleukin-18 - metabolism
Interleukin-1beta - metabolism
Investigations
Leishmania
Leishmania - drug effects
Leishmania - pathogenicity
Leishmaniasis
Leishmaniasis - drug therapy
Leishmaniasis - parasitology
Macrophages
Mice
Mice, Inbred BALB C
Parasites
Parasitic diseases
Plant Extracts - therapeutic use
Polymerase chain reaction
Rain forests
Rainforests
RNA
Tropical diseases
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
Brazil
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Summary:Calophyllum brasiliense is a plant from the Brazilian rain forests and has been used in folk medicine for the treatment of various diseases, including leishmaniasis. This infectious disease depends on the Leishmania sp. and the host immune response. C. brasiliense antileishmanial activity is well known, but the effects on immune response remain to be investigated. This study showed the leishmanicidal and immunomodulatory effects of a 30 μg/mL of hydroalcoholic extract of C. brasiliense in murine macrophages before and after Leishmania (Leishmania) amazonensis infection. The semiquantitative cytokine RNA expression was determined by RT-PCR and the anti-Leishmania activity was measured by infection index (IF). Hydroalcoholic extract of C. brasiliense reduced more than 95% of IF when used before and after Leishmania infection, with 3 and 24 h of treatment (p<0.05). C. brasiliense inhibited or reduced significantly (p<0.05) the TNF-α, IL-1β, IL-18, and IL-10 mRNA expression. The antileishmanial and anti-inflammatory effects showed the potential of C. brasiliense as an alternative therapy for leishmaniasis and it must be investigated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Elaine Hatanaka
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/6148351