Search Results - "Cairns, R."

Identification of direct targets and modified bases of RNA cytosine methyltransferases by Khoddami, Vahid, Cairns, Bradley R

“…Covalent links formed between methylation enzymes and a 5-azacytidine base incorporated into cellular RNA allow target enrichment and single base-pair…”
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The biology of chromatin remodeling complexes by Clapier, Cedric R, Cairns, Bradley R

“…The packaging of chromosomal DNA by nucleosomes condenses and organizes the genome, but occludes many regulatory DNA elements. However, this constraint also…”
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Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility by Jenkins, Timothy G, Aston, Kenneth I, Pflueger, Christian, Cairns, Bradley R, Carrell, Douglas T

“…Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders…”
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Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis by Hammoud, Saher Sue, Low, Diana H.P., Yi, Chongil, Carrell, Douglas T., Guccione, Ernesto, Cairns, Bradley R.

“…Adult germline stem cells (AGSCs) self-renew (Thy1+ enriched) or commit to gametogenesis (Kit+ enriched). To better understand how chromatin regulates AGSC…”
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Reprogramming the Maternal Zebrafish Genome after Fertilization to Match the Paternal Methylation Pattern by Potok, Magdalena E., Nix, David A., Parnell, Timothy J., Cairns, Bradley R.

“…Early vertebrate embryos must achieve totipotency and prepare for zygotic genome activation (ZGA). To understand this process, we determined the DNA…”
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β-Glucosidases by Ketudat Cairns, James R., Esen, Asim

“…β-Glucosidases (3.2.1.21) are found in all domains of living organisms, where they play essential roles in the removal of nonreducing terminal glucosyl…”
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Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment by Guo, Jingtao, Sosa, Enrique, Chitiashvili, Tsotne, Nie, Xichen, Rojas, Ernesto Javier, Oliver, Elizabeth, Plath, Kathrin, Hotaling, James M., Stukenborg, Jan-Bernd, Clark, Amander T., Cairns, Bradley R.

“…Human testis development in prenatal life involves complex changes in germline and somatic cell identity. To better understand, we profiled and analyzed…”
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Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution by Khoddami, Vahid, Yerra, Archana, Mosbruger, Timothy L., Fleming, Aaron M., Burrows, Cynthia J., Cairns, Bradley R.

“…The breadth and importance of RNA modifications are growing rapidly as modified ribonucleotides can impact the sequence, structure, function, stability, and…”
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Distinctive chromatin in human sperm packages genes for embryo development by Carrell, Douglas T, Cairns, Bradley R, Hammoud, Saher Sue, Nix, David A, Zhang, Haiying, Purwar, Jahnvi

“…Because nucleosomes are widely replaced by protamine in mature human sperm, the epigenetic contributions of sperm chromatin to embryo development have been…”
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The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty by Guo, Jingtao, Nie, Xichen, Giebler, Maria, Mlcochova, Hana, Wang, Yueqi, Grow, Edward J., Kim, Robin, Tharmalingam, Melissa, Matilionyte, Gabriele, Lindskog, Cecilia, Carrell, Douglas T., Mitchell, Rod T., Goriely, Anne, Hotaling, James M., Cairns, Bradley R.

“…The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the…”
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Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons by Hendrickson, Peter G, Doráis, Jessie A, Grow, Edward J, Whiddon, Jennifer L, Lim, Jong-Won, Wike, Candice L, Weaver, Bradley D, Pflueger, Christian, Emery, Benjamin R, Wilcox, Aaron L, Nix, David A, Peterson, C Matthew, Tapscott, Stephen J, Carrell, Douglas T, Cairns, Bradley R

“…Bradley Cairns, Douglas Carrell, Stephen Tapscott and colleagues transcriptionally profile human oocytes and preimplantation embryos and highlight DUX4-family…”
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Structure of the RSC complex bound to the nucleosome by Ye, Youpi, Wu, Hao, Chen, Kangjing, Clapier, Cedric R, Verma, Naveen, Zhang, Wenhao, Deng, Haiteng, Cairns, Bradley R, Gao, Ning, Chen, Zhucheng

“…The RSC complex remodels chromatin structure and regulates gene transcription. We used cryo-electron microscopy to determine the structure of yeast RSC bound…”
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Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development by Guo, Jingtao, Grow, Edward J., Yi, Chongil, Mlcochova, Hana, Maher, Geoffrey J., Lindskog, Cecilia, Murphy, Patrick J., Wike, Candice L., Carrell, Douglas T., Goriely, Anne, Hotaling, James M., Cairns, Bradley R.

“…Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation…”
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Aberrant sperm DNA methylation predicts male fertility status and embryo quality by Aston, Kenneth I., Ph.D, Uren, Philip J., Ph.D, Jenkins, Timothy G., Ph.D, Horsager, Alan, Ph.D, Cairns, Bradley R., Ph.D, Smith, Andrew D., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate whether male fertility status and/or embryo quality during in vitro fertilization (IVF) therapy can be predicted based on genomewide…”
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DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 by Rai, Kunal, Huggins, Ian J., James, Smitha R., Karpf, Adam R., Jones, David A., Cairns, Bradley R.

“…Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using zebrafish embryos we provide…”
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Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility by Hammoud, Saher Sue, B.S, Purwar, Jahnvi, B.S, Pflueger, Christian, M.S, Cairns, Bradley R., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate the associations between proper protamine incorporation and DNA methylation at imprinted loci. Design Experimental research study…”
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Structural basis for transglycosylation in glycoside hydrolase family GH116 glycosynthases by Pengthaisong, Salila, Hua, Yanling, Ketudat Cairns, James R.

“…Glycosynthases are glycoside hydrolase mutants that can synthesize oligosaccharides or glycosides from an inverted donor without hydrolysis of the products…”
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Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection by Clapier, Cedric R., Kasten, Margaret M., Parnell, Timothy J., Viswanathan, Ramya, Szerlong, Heather, Sirinakis, George, Zhang, Yongli, Cairns, Bradley R.

“…The RSC chromatin remodeler slides and ejects nucleosomes, utilizing a catalytic subunit (Sth1) with DNA translocation activity, which can pump DNA around the…”
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Dissecting mammalian spermatogenesis using spatial transcriptomics by Chen, Haiqi, Murray, Evan, Sinha, Anubhav, Laumas, Anisha, Li, Jilong, Lesman, Daniel, Nie, Xichen, Hotaling, Jim, Guo, Jingtao, Cairns, Bradley R., Macosko, Evan Z., Cheng, C. Yan, Chen, Fei

“…Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their…”
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Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) by Cairns, Stuart R, Scholefield, John H, Steele, Robert J, Dunlop, Malcolm G, Thomas, Huw J W, Evans, Gareth D, Eaden, Jayne A, Rutter, Matthew D, Atkin, Wendy P, Saunders, Brian P, Lucassen, Anneke, Jenkins, Paul, Fairclough, Peter D, Woodhouse, Christopher R J

“…The British Society of Gastroenterology (BSG) and the Association of Coloproctology for Great Britain and Ireland (ACPGBI) commissioned this update of the 2002…”
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