Search Results - "Cairncross, Gregory"

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma by Perry, James R, Laperriere, Normand, O’Callaghan, Christopher J, Brandes, Alba A, Menten, Johan, Phillips, Claire, Fay, Michael, Nishikawa, Ryo, Cairncross, J. Gregory, Roa, Wilson, Osoba, David, Rossiter, John P, Sahgal, Arjun, Hirte, Hal, Laigle-Donadey, Florence, Franceschi, Enrico, Chinot, Olivier, Golfinopoulos, Vassilis, Fariselli, Laura, Wick, Antje, Feuvret, Loic, Back, Michael, Tills, Michael, Winch, Chad, Baumert, Brigitta G, Wick, Wolfgang, Ding, Keyue, Mason, Warren P

“…Older patients with glioblastoma appear to benefit more from treatment combining a shorter course (3 weeks rather than 6 weeks) of radiotherapy together with…”
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Phase III Trial of Chemoradiotherapy for Anaplastic Oligodendroglioma: Long-Term Results of RTOG 9402 by Cairncross, Gregory, Wang, Meihua, Shaw, Edward, Jenkins, Robert, Brachman, David, Buckner, Jan, Fink, Karen, Souhami, Luis, Laperriere, Normand, Curran, Walter, Mehta, Minesh

“…Anaplastic oligodendrogliomas, pure (AO) and mixed (anaplastic oligoastrocytoma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether…”
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2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas by Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Ong, Wei Qiang, Luchman, Hema Artee, Cairncross, J Gregory, Huang, Bo, Pieper, Russell O, Phillips, Joanna J, Ronen, Sabrina M

“…Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane…”
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Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression by De Boeck, Astrid, Ahn, Bo Young, D’Mello, Charlotte, Lun, Xueqing, Menon, Shyam V., Alshehri, Mana M., Szulzewsky, Frank, Shen, Yaoqing, Khan, Lubaba, Dang, Ngoc Ha, Reichardt, Elliott, Goring, Kimberly-Ann, King, Jennifer, Grisdale, Cameron J., Grinshtein, Natalie, Hambardzumyan, Dolores, Reilly, Karlyne M., Blough, Michael D., Cairncross, J. Gregory, Yong, V. Wee, Marra, Marco A., Jones, Steven J. M., Kaplan, David R., McCoy, Kathy D., Holland, Eric C., Bose, Pinaki, Chan, Jennifer A., Robbins, Stephen M., Senger, Donna L.

“…Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of…”
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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors by Ahmad, Shiekh Tanveer, Rogers, Alexandra D., Chen, Myra J., Dixit, Rajiv, Adnani, Lata, Frankiw, Luke S., Lawn, Samuel O., Blough, Michael D., Alshehri, Mana, Wu, Wei, Marra, Marco A., Robbins, Stephen M., Cairncross, J. Gregory, Schuurmans, Carol, Chan, Jennifer A.

“…Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its cancer link, little is known of Cic’s function in the…”
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cIMPACT‐NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification by Louis, David N., Aldape, Ken, Brat, Daniel J., Capper, David, Ellison, David W., Hawkins, Cynthia, Paulus, Werner, Perry, Arie, Reifenberger, Guido, Figarella‐Branger, Dominique, Wesseling, Pieter, Batchelor, Tracy T., Gregory Cairncross, J., Pfister, Stefan M., Rutkowski, Stefan, Weller, Michael, Wick, Wolfgang, von Deimling, Andreas

“…The 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) is a major shift in the way neuropathologists analyze…”
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Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy by Louis, David N., Aldape, Ken, Brat, Daniel J., Capper, David, Ellison, David W., Hawkins, Cynthia, Paulus, Werner, Perry, Arie, Reifenberger, Guido, Figarella-Branger, Dominique, Wesseling, Pieter, Batchelor, Tracy T., Cairncross, J. Gregory, Pfister, Stefan M., Rutkowski, Stefan, Weller, Michael, Wick, Wolfgang, von Deimling, Andreas

“…The recent publication of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) represents a significant…”
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ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts by Yuan, Alice L, Ricks, Christian B, Bohm, Alexandra K, Lun, Xueqing, Maxwell, Lori, Safdar, Shahana, Bukhari, Shazreh, Gerber, Amanda, Sayeed, Wajid, Bering, Elizabeth A, Pedersen, Haley, Chan, Jennifer A, Shen, Yaoqing, Marra, Marco, Kaplan, David R, Mason, Warren, Goodman, Lindsey D, Ezhilarasan, Ravesanker, Kaufmann, Ascher B, Cabral, Matthew, Robbins, Steve M, Senger, Donna L, Cahill, Daniel P, Sulman, Erik P, Cairncross, J Gregory, Blough, Michael D

“…Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in…”
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IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism by Izquierdo-Garcia, Jose L, Viswanath, Pavithra, Eriksson, Pia, Cai, Larry, Radoul, Marina, Chaumeil, Myriam M, Blough, Michael, Luchman, H Artee, Weiss, Samuel, Cairncross, J Gregory, Phillips, Joanna J, Pieper, Russell O, Ronen, Sabrina M

“…Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate…”
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Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients by Climans, Seth A., Brandes, Alba A., Cairncross, J. Gregory, Ding, Keyue, Fay, Michael, Laperriere, Normand, Menten, Johan, Nishikawa, Ryo, O’Callaghan, Christopher J., Perry, James R., Phillips, Claire, Roa, Wilson, Wick, Wolfgang, Winch, Chad, Mason, Warren P.

“…Introduction Tumor-related epilepsy may respond to chemotherapy. In a previously-published multi-centre randomized clinical trial of 562 elderly glioblastoma…”
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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial by Stupp, Roger, Dr, Hegi, Monika E, PhD, Mason, Warren P, MD, van den Bent, Martin J, MD, Taphoorn, Martin JB, Janzer, Robert C, MD, Ludwin, Samuel K, MD, Allgeier, Anouk, PhD, Fisher, Barbara, MD, Belanger, Karl, MD, Hau, Peter, MD, Brandes, Alba A, MD, Gijtenbeek, Johanna, MD, Marosi, Christine, MD, Vecht, Charles J, MD, Mokhtari, Karima, PhD, Wesseling, Pieter, MD, Villa, Salvador, MD, Eisenhauer, Elizabeth, MD, Gorlia, Thierry, MSc, Weller, Michael, MD, Lacombe, Denis, MD, Cairncross, J Gregory, MD, Mirimanoff, René-Olivier, MD

“…Summary Background In 2004, a randomised phase III trial by the European Organisation for Research and Treatment of Cancer (EORTC) and National Cancer…”
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Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells by Sarkar, Susobhan, Döring, Axinia, Zemp, Franz J, Silva, Claudia, Lun, Xueqing, Wang, Xiuling, Kelly, John, Hader, Walter, Hamilton, Mark, Mercier, Philippe, Dunn, Jeff F, Kinniburgh, Dave, van Rooijen, Nico, Robbins, Stephen, Forsyth, Peter, Cairncross, Gregory, Weiss, Samuel, Yong, V Wee

“…Growth of malignant glioma involves a rare population of stem-like cells in the brain called brain tumor-initiating cells (BTICs). This study shows that immune…”
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Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma by MURAT, Anastasia, MIGLIAVACCA, Eugenia, HAINFELLNER, Johannes A, HEPPNER, Frank L, DIETRICH, Pierre-Yves, ZIMMER, Yitzhak, CAIRNCROSS, J. Gregory, JANZER, Robert-Charles, DOMANY, Eytan, DELORENZI, Mauro, STUPP, Roger, HEGI, Monika E, GORLIA, Thierry, LAMBIV, Wanyu L, SHAY, Tal, HAMOU, Marie-France, DE TRIBOLET, Nicolas, REGLI, Luca, WICK, Wolfgang, KOUWENHOVEN, Mathilde C. M

“…Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and,…”
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Surgical management of incidentally discovered diffusely infiltrating low-grade glioma by Opoku-Darko, Michael, Lang, Stefan T, Artindale, James, Cairncross, J Gregory, Sevick, Robert J, Kelly, John J P

“…OBJECTIVE Occasionally, diffusely infiltrating low-grade gliomas (LGGs) are identified as incidental findings in patients who have no signs or symptoms that…”
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Phase III Trial of Chemotherapy Plus Radiotherapy Compared With Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402 by CAIRNCROSS, Gregory, BERKEY, Brian, MEHTA, Minesh, CURRAN, Walter, SHAW, Edward, JENKINS, Robert, SCHEITHAUER, Bernd, BRACHMAN, David, BUCKNER, Jan, FINK, Karen, SOUHAMI, Luis, LAPERIERRE, Normand

“…Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are treated with surgery and radiotherapy (RT) at diagnosis, but they also respond to…”
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An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging by Drabycz, Sylvia, Roldán, Gloria, de Robles, Paula, Adler, Daniel, McIntyre, John B., Magliocco, Anthony M., Cairncross, J. Gregory, Mitchell, J. Ross

“…In glioblastoma (GBM), promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is associated with benefit from chemotherapy…”
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Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3 by Gorlia, Thierry, Dr, van den Bent, Martin J, MD, Hegi, Monika E, PhD, Mirimanoff, René O, MD, Weller, Michael, MD, Cairncross, J Gregory, MD, Eisenhauer, Elizabeth, MD, Belanger, Karl, MD, Brandes, Alba A, MD, Allgeier, Anouk, PhD, Lacombe, Denis, MD, Stupp, Roger, MD

“…Summary Background A randomised trial published by the European Organisation for Research and Treatment of Cancer (EORTC) and the National Cancer Institute of…”
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Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments by Shen, Yaoqing, Grisdale, Cameron J., Islam, Sumaiya A., Bose, Pinaki, Lever, Jake, Zhao, Eric Y., Grinshtein, Natalie, Ma, Yussanne, Mungall, Andrew J., Moore, Richard A., Lun, Xueqing, Senger, Donna L., Robbins, Stephen M., Wang, Alice Yijun, MacIsaac, Julia L., Kobor, Michael S., Luchman, H. Artee, Weiss, Samuel, Chan, Jennifer A., Blough, Michael D., Kaplan, David R., Cairncross, J. Gregory, Marra, Marco A., Jones, Steven J. M.

“…Glioblastoma multiforme (GBM) is the most deadly brain tumor, and currently lacks effective treatment options. Brain tumor-initiating cells (BTICs) and…”
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Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner by Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Luchman, Hema Artee, Gregory Cairncross, J, Pieper, Russell O, Phillips, Joanna J, Ronen, Sabrina M

“…Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as…”
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On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells by Stechishin, Owen D, Luchman, H Artee, Ruan, Yibing, Blough, Michael D, Nguyen, Stephanie A, Kelly, John J, Cairncross, J Gregory, Weiss, Samuel

“…Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity. GBM-derived…”
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