Search Results - "Cairó, Jordi Joan"

Lactate and glucose concomitant consumption as a self-regulated pH detoxification mechanism in HEK293 cell cultures by Liste-Calleja, Leticia, Lecina, Martí, Lopez-Repullo, Jonatan, Albiol, Joan, Solà, Carles, Cairó, Jordi Joan

“…One of the most important limitations of mammalian cell-based processes is the secretion and accumulation of lactate as a by-product of their metabolism. Among…”
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HEK293 cell culture media study towards bioprocess optimization: Animal derived component free and animal derived component containing platforms by Liste-Calleja, Leticia, Lecina, Martí, Cairó, Jordi Joan

“…The increasing demand for biopharmaceuticals produced in mammalian cells has lead industries to enhance bioprocess volumetric productivity through different…”
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HEK293 Cell-Based Bioprocess Development at Bench Scale by Means of Online Monitoring in Shake Flasks (RAMOS and SFR) by Anderlei, Tibor, Keebler, Michael V, Cairó, Jordi Joan, Lecina, Martí

“…The platforms for bioprocess development have been developed in parallel to the needs of the manufacturing industry of biopharmaceuticals, aiming to ensure the…”
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Considerations on the lactate consumption by CHO cells in the presence of galactose by Altamirano, Claudia, Illanes, Andres, Becerra, Silvana, Cairó, Jordi Joan, Gòdia, Francesc

“…A CHO cell line producing t-PA was cultured using glutamate and glucose or galactose to decrease the formation of metabolic end-products and therefore…”
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A simplified implementation of the stationary liquid mass balance method for on‐line OUR monitoring in animal cell cultures by Fontova, Andreu, Lecina, Martí, López‐Repullo, Jonatan, Martínez‐Monge, Iván, Comas, Pere, Bragós, Ramon, Cairó, Jordi Joan

“…BACKGROUND Compared with other methods, the stationary liquid mass balance method for oxygen uptake rate (OUR) determination offers advantages in terms of…”
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Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly by Farràs, Mercè, Miret, Joan, Camps, Marc, Román, Ramón, Martínez, Óscar, Pujol, Xavier, Erb, Stéphane, Ehkirch, Anthony, Cianferani, Sarah, Casablancas, Antoni, Cairó, Jordi Joan

“…Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome…”
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The Effect of the Expression of the Antiapoptotic BHRF1 Gene on the Metabolic Behavior of a Hybridoma Cell Line by Martínez-Monge, Iván, Comas, Pere, Catalán-Tatjer, David, Prat, Jordi, Casablancas, Antoni, Paredes, Carlos, Lecina, Martí, Cairó, Jordi Joan

“…One of the most important limitations of mammalian cells-based bioprocesses, and particularly hybridoma cell lines, is the accelerated metabolism related to…”
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Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab by Farràs, Mercè, Román, Ramón, Camps, Marc, Miret, Joan, Martínez, Óscar, Pujol, Xavier, Casablancas, Antoni, Cairó, Jordi Joan

“…Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased…”
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Real‐time and on‐line monitoring of morphological cell parameters using electrical impedance spectroscopy measurements by Sarró, Enric, Lecina, Martí, Fontova, Andreu, Gòdia, Francesc, Bragós, Ramon, Cairó, Jordi J

“…BACKGROUND: Acquisition of electrical impedance spectroscopy (EIS) measurements enables one to obtain information about the features of cell cultures, which…”
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Non-additive effects of multiple amino acid substitutions on antigen-antibody recognition by Mateu, M G, Andreu, D, Carreño, C, Roig, X, Cairó, J J, Camarero, J A, Giralt, E, Domingo, E

“…Synthetic peptides have been used to mimic the main antigenic site of foot-and-mouth disease virus (FMDV) of serotype C and of several variant isolates. This…”
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HEK293 cell culture media study: increasing cell density for different bioprocess applications by Liste-Calleja, Leticia, Lecina, Martí, Cairó, Jordi Joan

“…Doc number: P51…”
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Preliminary studies of cell culture strategies for bioprocess development based on HEK293 cells by Liste-Calleja, Leticia, López-Repullo, Jonatan, Lecina, Martí, Cairó, Jordi Joan

“…Doc number: P52…”
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A Simplified implementation of the O.U.R. stationary liquid mass balance estimation method for On-line monitoring in Animal cell production processes by Fontova, Andreu, López-Repullo, Jonatan, Lecina, Martí, Bragós, Ramon, Cairó, Jordi J

“…This works offers a simplified embodiment of the Stationary liquid mass balance method for the continuous estimate of the OUR estimation by means of the use of…”
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Structural changes of Arthrospira sp. after low energy sonication treatment for microalgae harvesting: Elucidating key parameters to detect the rupture of gas vesicles by Lecina, Martí, Sanchez, Benjamin, Solà, Carles, Prat, Jordi, Roldán, Mònica, Hernández, Mariona, Bragós, Ramon, Paredes, Carlos J., Cairó, Jordi J.

“…•Low energy sonication (LES) treatment suppresses Arthrospira sp. buoyancy.•TEM images evidenced that loss of buoyancy was related to gas vesicles rupture.•TEM…”
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Identification of key patterns in the metabolism of hybridoma cells in culture by Sanfeliu, Anna, Paredes, Carles, Cairó, Jordi Joan, Gòdia, Francesc

“…In transformed cell lines, glucose and glutamine transport into cells as well as glycolysis and glutaminolysis pathways occur at high rates. As a consequence,…”
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Metabolic engineering of apoptosis in cultured animal cells: implications for the biotechnology industry by Vives, Joaquim, Juanola, Sandra, Cairó, Jordi Joan, Gòdia, Francesc

“…Animal cells have been widely used to obtain a wide range of products for human and animal healthcare applications. However, the extreme sensitivity of these…”
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Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly by Farràs, Mercè, Miret, Joan, Camps, Marc, Román, Ramón, Martínez, Óscar, Pujol, Xavier, Erb, Stéphane, Ehkirch, Anthony, Cianferani, Sarah, Casablancas, Antoni, Cairó, Jordi Joan

“…Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome…”
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Development of a simple disposable six minibioreactor system for suspension mammalian cell culture by Soley, A., Fontova, A., Gálvez, J., Sarró, E., Lecina, M., Bragós, R., Cairó, J.J., Gòdia, F.

“…► A simple disposable biocompatible plastic six minibioreactor system is developed. ► The system allows performing parallel experiments for mammalian cell…”
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Determination of ammonium and L-glutamine in hybridoma cell cultures by sequential flow injection analysis by Campmajó, C, Cairó, J J, Sanfeliu, A, Martínez, E, Alegret, S, Gòdia, F

“…A flow injection analytical system based on a gas diffusion membrane module for ammonia and an ammonium flow-through potentiometric detector has been set up…”
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Substitution of transferrin by FeCl3 in the development of a low foetal calf serum concentration medium for KB-26.5 hybridoma cell line by DAMGAARD, B, SANFELIU, A, CAIRO, J. J, CASAS, C, SOLA, C, GODIA, F

“…KB-26.5, a murine hybridoma cell line producing an IgG3 monoclonal antibody used in blood type determination, primarily adapted to grow at 5% foetal calf serum…”
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