Search Results - "Caine, Joanne"

Naturally occurring polyphenolic inhibitors of amyloid beta aggregation by Churches, Quentin I., Caine, Joanne, Cavanagh, Kate, Epa, Vidana Chandana, Waddington, Lynne, Tranberg, C. Elisabet, Meyer, Adam G., Varghese, Jose N., Streltsov, Victor, Duggan, Peter J.

“…Alzheimer’s disease is the most common neurodegenerative disease and is one of the main causes of death in developed countries. Consumption of foods rich in…”
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Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide by Streltsov, Victor A, Chandana Epa, V, James, Simon A, Churches, Quentin I, Caine, Joanne M, Kenche, Vijaya B, Barnham, Kevin J

“…Extended X-ray absorption fine structure spectroscopy, mass spectrometry, dynamic light scattering and density functional theory are combined to derive…”
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Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation by Madej, Mariusz P., Coia, Gregory, Williams, Charlotte C., Caine, Joanne M., Pearce, Lesley A., Attwood, Rebecca, Bartone, Nick A., Dolezal, Olan, Nisbet, Rebecca M., Nuttall, Stewart D., Adams, Timothy E.

“…Sortase‐mediated protein ligation is a biological covalent conjugation system developed from the enzymatic cell wall display mechanism found in Staphylococcus…”
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Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization by Ryan, Timothy M, Caine, Joanne, Mertens, Haydyn D T, Kirby, Nigel, Nigro, Julie, Breheney, Kerry, Waddington, Lynne J, Streltsov, Victor A, Curtain, Cyril, Masters, Colin L, Roberts, Blaine R

“…Alzheimer's disease is the leading cause of dementia in the elderly. Pathologically it is characterized by the presence of amyloid plaques and neuronal loss…”
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Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast by Bharadwaj, Prashant R, Verdile, Giuseppe, Barr, Renae K, Gupta, Veer, Steele, John W, Lachenmayer, M Lenard, Yue, Zhenyu, Ehrlich, Michelle E, Petsko, Gregory, Ju, Shulin, Ringe, Dagmar, Sankovich, Sonia E, Caine, Joanne M, Macreadie, Ian G, Gandy, Sam, Martins, Ralph N

“…Latrepirdine (Dimebon), an anti-histamine, has shown some benefits in trials of neurodegenerative diseases characterized by accumulation of aggregated or…”
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide by Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N., Streltsov, Victor A.

“…ABSTRACT Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid‐β (Aβ) peptide and its interaction…”
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Anti-amyloidogenic properties of some phenolic compounds by Porzoor, Afsaneh, Alford, Benjamin, Hügel, Helmut M, Grando, Danilla, Caine, Joanne, Macreadie, Ian

“…A family of 21 polyphenolic compounds consisting of those found naturally in danshen and their analogues were synthesized and subsequently screened for their…”
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Pretreatment of chemically-synthesized Aβ42 affects its biological activity in yeast by Porzoor, Afsaneh, Caine, Joanne M, Macreadie, Ian G

“…The tendency of amyloid β (Aβ 42 ) peptide to misfold and aggregate into insoluble amyloid fibrils in Alzheimer's disease (AD) has been well documented…”
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Design of non-aggregating variants of Aβ peptide by Caine, Joanne M, Churches, Quentin, Waddington, Lynne, Nigro, Julie, Breheney, Kerry, Masters, Colin L, Nuttall, Stewart D, Streltsov, Victor A

“…Self association of the amyloid-β (Aβ42) peptide into oligomers, high molecular weight forms, fibrils and ultimately neuritic plaques, has been correlated with…”
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Oligomerization and toxicity of Aβ fusion proteins by Caine, Joanne M., Bharadwaj, Prashant R., Sankovich, Sonia E., Ciccotosto, Giuseppe D., Streltsov, Victor A., Varghese, Jose

“…► We expressed amyloid-β (Aβ) peptide as a soluble maltose binding protein fusion (MBP-Aβ42 and MBP-Aβ16). ► The full length Aβ peptide fusion, MBP-Aβ42, forms…”
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Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline by Wu, Qian, Caine, Joanne M., Thomson, Stuart A., Slavica, Meri, Grunewald, Gary L., McLeish, Michael J.

“…Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in…”
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Molecular Recognition of Sub-micromolar Inhibitors by the Epinephrine-Synthesizing Enzyme Phenylethanolamine N-Methyltransferase by McMillan, Fiona M, Archbold, Julia, McLeish, Michael J, Caine, Joanne M, Criscione, Kevin R, Grunewald, Gary L, Martin, Jennifer L

“…The crystal structures of human phenylethanolamine N-methyltransferase in complex with S-adenosyl-l-homocysteine (7, AdoHcy) and either…”
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Noncovalent scFv multimers of tumor-targeting anti-Lewis(y) hu3S193 humanized antibody by Power, Barbara E, Doughty, Larissa, Shapira, Deborah R, Burns, John E, Bayly, Ann M, Caine, Joanne M, Liu, Zhanqi, Scott, Andrew M, Hudson, Peter J, Kortt, Alexander A

“…Single-chain variable fragments (scFvs) of anti-Lewis(y) hu3S193 humanized antibody were constructed by joining the V(H) and V(L) domains with either +2…”
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Construction, expression and characterisation of a single-chain diabody derived from a humanised anti-Lewis Y cancer targeting antibody using a heat-inducible bacterial secretion vector by POWER, Barbara E, CAINE, Joanne M, HUDSON, Peter J, BURNS, John E, SHAPIRA, Deborah R, HATTARKI, Meghan K, TAHTIS, Kiki, LEE, F-T, SMYTH, Fiona E, SCOTT, Andrew M, KORTT, Alexander A

“…A single-chain antibody fragment (scFv) of the humanised monoclonal antibody, hu3S193, that reacts specifically with Le(y) antigen expressed in numerous human…”
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Transcription errors induce proteotoxic stress and shorten cellular lifespan by Vermulst, Marc, Denney, Ashley S., Lang, Michael J., Hung, Chao-Wei, Moore, Stephanie, Moseley, M. Arthur, Thompson, J. Will, Madden, Victoria, Gauer, Jacob, Wolfe, Katie J., Summers, Daniel W., Schleit, Jennifer, Sutphin, George L., Haroon, Suraiya, Holczbauer, Agnes, Caine, Joanne, Jorgenson, James, Cyr, Douglas, Kaeberlein, Matt, Strathern, Jeffrey N., Duncan, Mara C., Erie, Dorothy A.

“…Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells…”
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Quantitation of seven transmembrane proteins from the DHA biosynthesis pathway in genetically engineered canola by targeted mass spectrometry by Colgrave, Michelle L., Byrne, Keren, Pillai, Sapna Vibhakaran, Dong, Bei, Leonforte, Antonio, Caine, Joanne, Kowalczyk, Lukasz, Scoble, Judith A., Petrie, James R., Singh, Surinder, Zhou, Xue-Rong

“…Examining tissue-specific expression and the measurement of protein abundance are important steps when assessing the performance of genetically engineered…”
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Proteomics reveals the in vitro protein digestibility of seven transmembrane enzymes from the docosahexaenoic acid biosynthesis pathway by Colgrave, Michelle L., Byrne, Keren, Caine, Joanne, Kowalczyk, Lukasz, Vibhakaran Pillai, Sapna, Dong, Bei, Lovrecz, George, MacIntosh, Susan, Scoble, Judith A., Petrie, James R., Singh, Surinder, Zhou, Xue-Rong

“…The measurement of protein digestibility is one of the key steps in determining the safety of a genetically modified crop that has been traditionally…”
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Pretreatment of chemically-synthesized Aβ 42 affects its biological activity in yeast by Porzoor, Afsaneh, Caine, Joanne M, Macreadie, Ian G

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Noncovalent scFv multimers of tumor‐targeting anti‐Lewisy hu3S193 humanized antibody by Power, Barbara E., Doughty, Larissa, Shapira, Deborah R., Burns, John E., Bayly, Ann M., Caine, Joanne M., Liu, Zhanqi, Scott, Andrew M., Hudson, Peter J., Kortt, Alexander A.

“…Single‐chain variable fragments (scFvs) of anti‐Lewisy hu3S193 humanized antibody were constructed by joining the VH and VL domains with either +2 residues, +1…”
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Correction: Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan by Vermulst, Marc, Denney, Ashley S., Lang, Michael J., Hung, Chao-Wei, Moore, Stephanie, Moseley, M. Arthur, Thompson, J. Will, Madden, Victoria, Gauer, Jacob, Wolfe, Katie J., Summers, Daniel W., Schleit, Jennifer, Sutphin, George L., Haroon, Suraiya, Holczbauer, Agnes, Caine, Joanne, Jorgenson, James, Cyr, Douglas, Kaeberlein, Matt, Strathern, Jeffrey N., Duncan, Mara C., Erie, Dorothy A.

“…Nature Communications 6, Article number: 8065 (2015); Published 25 August 2015; Updated 14 October 2015 The original version of this Article contained an error…”
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