Search Results - "Caine, Darren"

Sequential Acetic Acid–Sodium Chloride Treatment to Control Salt Stoichiometry of a Hydrochloride Salt by Caine, Darren M, Paternoster, Ian L, Sedehizadeh, Simon, Shapland, Peter D. P

“…The sequential treatment of an intermediate in the synthesis of GSK159797 with a protic acid and sodium chloride was developed to control the stoichiometry of…”
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Highly Selective Primary Alkoxycarboxylation and Esterification of Unprotected Pyranose Derivatives Mediated by Scandium(III) Triflate Catalysis by McClure, Michael S., Berry, Malcolm B., Caine, Darren, Crawford, Claire, Crump, Brian C., Glover, Bobby N., Kedia, Sandeep B., Millar, Alan, Mitchell, Mark B., Nichols, Christopher J., Patterson, Daniel E., Powers, Jeremiah

“…A highly selective method for the alkoxycarboxylation and acylation of primary alcohols of pyranose derivatives is described. The reaction is high yielding and…”
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A practical, two-stage preparation of benzyl (3 R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2 S,3 S)-2,3-bis[(4-methylbenzoyl)oxy]butanediote (2:1) by Barrett, Roger, Caine, Darren M, Cardwell, Kevin S, Cooke, Jason W.B, Lawrence, Ron M, Scott, Peter, Sjolin, Åsa

“…A convenient, efficient and cost-effective two-stage synthesis of benzyl (3 R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2 S,3…”
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Efficient synthesis of 2-trihalomethyl-5-cyanopyridines by Cooke, Jason WB, Coleman, Mark J, Caine, Darren M, Jenkins, Kevin P

“…Efficient and practicable routes to 2-trifluoromethyl-5-cyanopyridine, 2-bromodifluoromethyl-5-cyanopyridine and 2-chlorodifluoromethyl-5-cyanopyridine have…”
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A Novel and Selective Approach to Enantiomerically Pure Bicyclic-Trans-Lactams via a Titanium Enolate of a Thiopyridyl Ester by Cooke, Jason W. B, Berry, Malcolm B, Caine, Darren M, Cardwell, Kevin S, Cook, John S, Hodgson, Anne

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Integration of Recognition, Diagnostic, and Treatment Strategies between Prehospital Emergency Medical Services and Hospital Emergency Departments in the Management of Patients with Acute Sepsis and Septic Shock by Duguay, Darren Caine

“…Sepsis and its manifestation as a shock state in "septic shock" have long caused medical issues and death worldwide. The disease requires quick identification,…”
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On the α-lithiation-rearrangement of N-toluensulfonyl aziridines: mechanistic and synthetic aspects by O'Brien, Peter, Rosser, Clare M, Caine, Darren

“…A detailed study of the rearrangement of five cycloalkene N-toluenesulfonyl (tosyl) aziridines using sec-butyllithium (with and without added ligands such as…”
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Highly Selective Primary Alkoxycarboxylation and Esterification of Unprotected Pyranose Derivatives Mediated by Scandium(III) Triflate Catalysis (Eur. J. Org. Chem. 19/2012) by McClure, Michael S., Berry, Malcolm B., Caine, Darren, Crawford, Claire, Crump, Brian C., Glover, Bobby N., Kedia, Sandeep B., Millar, Alan, Mitchell, Mark B., Nichols, Christopher J., Patterson, Daniel E., Powers, Jeremiah

“…The cover picture shows the highly selective scandium‐catalyzed alkoxycarboxylation of an unprotected pyranose. The utility of this highly selective reaction…”
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Process Development and Scale Up of a Glycine Antagonist by Banks, Adam, Breen, Gary F, Caine, Darren, Carey, John S, Drake, Christopher, Forth, Michael A, Gladwin, Asa, Guelfi, Simone, Hayes, Jerome F, Maragni, Paolo, Morgan, David O, Oxley, Paul, Perboni, Alcide, Popkin, Matthew E, Rawlinson, Fiona, Roux, Guillaume

“…A synthetic route amenable to large-scale synthesis of the glycine antagonist…”
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α-Lithiation-rearrangement of N-toluenesulfonyl aziridines with sec-butyllithium and (−)-sparteine: opposite sense of asymmetric induction to epoxides by O'Brien, Peter, Rosser, Clare M, Caine, Darren

“…The α-lithiation rearrangement of three cyclic N-toluenesulfonyl (tosyl) aziridines has been carried out using sec-butyllithium/(−)-sparteine. In each case, it…”
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Reductive Alkylation of β-Alkoxy Aziridines:  New Route to Substituted Allylic Amines by Rosser, Clare M, Coote, Susannah C, Kirby, Jonathan P, O'Brien, Peter, Caine, Darren

“…A new route to substituted cyclic allylic amines via the reductive alkylation of β-alkoxy aziridines using excess alkyllithium reagents is described…”
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Diastereocontrolled synthesis of trans- and cis-meso-cyclopentene aziridines by Caine, Darren, O'Brien, Peter, Rosser, Clare M

“…[reaction: see text] The synthesis of novel substituted meso-aziridines is described: aziridination of 4-tert-butyldiphenylsilyloxy-cyclopent-1-ene is trans…”
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Diastereocontrolled Synthesis of trans- and cis-m eso-Cyclopentene Aziridines by Caine, Darren, O'Brien, Peter, Rosser, Clare M

“…The synthesis of novel substituted meso-aziridines is described:  aziridination of 4-tert-butyldiphenylsilyloxy-cyclopent-1-ene is trans selective using…”
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