Search Results - "Cain, Kelvin"

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms by Feoktistova, Maria, Geserick, Peter, Kellert, Beate, Dimitrova, Diana Panayotova, Langlais, Claudia, Hupe, Mike, Cain, Kelvin, MacFarlane, Marion, Häcker, Georg, Leverkus, Martin

“…The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an…”
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Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate by Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion

“…The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis. DISC assembly and activation are controlled by c-FLIP isoforms, which…”
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Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate by Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion

“…Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC),…”
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PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair by Craxton, Andrew, Munnur, Deeksha, Jukes-Jones, Rebekah, Skalka, George, Langlais, Claudia, Cain, Kelvin, Malewicz, Michal

“…PAXX is a recently identified component of the nonhomologous end joining (NHEJ) DNA repair pathway. The molecular mechanisms of PAXX action remain largely…”
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eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR by Wilczynska, Ania, Gillen, Sarah L., Schmidt, Tobias, Meijer, Hedda A., Jukes-Jones, Rebekah, Langlais, Claudia, Kopra, Kari, Lu, Wei-Ting, Godfrey, Jack D., Hawley, Benjamin R., Hodge, Kelly, Zanivan, Sara, Cain, Kelvin, Le Quesne, John, Bushell, Martin

“…Abstract Background Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA…”
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Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity by Dott, William, Mistry, Pratibha, Wright, Jayne, Cain, Kelvin, Herbert, Karl E

“…Mitochondrial toxicity is increasingly being implicated as a contributing factor to many xenobiotic-induced organ toxicities, including skeletal muscle…”
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Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells by Chernova, Tatyana, Grosso, Stefano, Sun, Xiao-Ming, Tenor, Angela Rubio, Cabeza, Joaquin Zacarias, Craxton, Andrew, Self, Emily L, Nakas, Apostolos, Cain, Kelvin, MacFarlane, Marion, Willis, Anne E

“…Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a clinical presentation at an advanced stage of the disease. Current…”
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Glucose-a sweet way to die: Metabolic switching modulates tumor cell death by MacFarlane, Marion, Robinson, Gemma L., Cain, Kelvin

“…TRAIL, a putative anticancer cytokine, induces extrinsic cell death by activating the caspase cascade directly (Type I cells) via the death-inducing signaling…”
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The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors by Hardy, Rachel E, Chung, Injae, Yu, Yizhou, Loh, Samantha H Y, Morone, Nobuhiro, Soleilhavoup, Clement, Travaglio, Marco, Serreli, Riccardo, Panman, Lia, Cain, Kelvin, Hirst, Judy, Martins, Luis M, MacFarlane, Marion, Pryde, Kenneth R

“…Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar…”
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NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair by Munnur, Deeksha, Somers, Joanna, Skalka, George, Weston, Ria, Jukes-Jones, Rebekah, Bhogadia, Mohammed, Dominguez, Cyril, Cain, Kelvin, Ahel, Ivan, Malewicz, Michal

“…Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly…”
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Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression by Busacca, Sara, Zhang, Qi, Sharkey, Annabel, Dawson, Alan G., Moore, David A., Waller, David A., Nakas, Apostolos, Jones, Carolyn, Cain, Kelvin, Luo, Jin-li, Salcedo, Adriana, Salaroglio, Iris Chiara, Riganti, Chiara, Le Quesne, John, John, Tom, Boutros, Paul C., Zhang, Shu-Dong, Fennell, Dean A.

“…We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine…”
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The Apaf-1 apoptosome: a large caspase-activating complex by Cain, Kelvin, Bratton, Shawn B., Cohen, Gerald M.

“…It is increasingly recognized that many key biological processes, including apoptosis, are carried out within very large multi-protein complexes. Apoptosis can…”
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Protein Profiling of Plasma Membranes Defines Aberrant Signaling Pathways in Mantle Cell Lymphoma by Boyd, Robert S., Jukes-Jones, Rebekah, Walewska, Renata, Brown, David, Dyer, Martin J.S., Cain, Kelvin

“…We used shotgun proteomics to identify plasma membrane and lipid raft proteins purified from B cells obtained from mantle cell lymphoma (MCL) patients in…”
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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) by Akasaka, Takashi, Balasas, Theodore, Russell, Lisa J., Sugimoto, Kei-ji, Majid, Aneela, Walewska, Renata, Karran, E. Loraine, Brown, David G., Cain, Kelvin, Harder, Lana, Gesk, Stefan, Martin-Subero, Jose Ignacio, Atherton, Mark G., Brüggemann, Monika, Calasanz, María José, Davies, Teresa, Haas, Oskar A., Hagemeijer, Anne, Kempski, Helena, Lessard, Michel, Lillington, Debra M., Moore, Sarah, Nguyen-Khac, Florence, Radford-Weiss, Isabelle, Schoch, Claudia, Struski, Stéphanie, Talley, Polly, Welham, Melanie J., Worley, Helen, Strefford, Jon C., Harrison, Christine J., Siebert, Reiner, Dyer, Martin J.S.

“…CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid…”
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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome by Beere, Helen M, Wolf, Beni B, Cain, Kelvin, Mosser, Dick D, Mahboubi, Artin, Kuwana, Tomomi, Tailor, Pankaj, Morimoto, Richard I, Cohen, Gerald M, Green, Douglas R

“…The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can interfere with the process of…”
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Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle by Dott, William, Wright, Jayne, Cain, Kelvin, Mistry, Pratibha, Herbert, Karl E.

“…There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel…”
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Chemical-Induced Apoptosis: Formation of the Apaf-1 Apoptosome by Cain, Kelvin

“…Abstract Many environmental and therapeutic agents initiate apoptotic cell death by inducing the release of cytochrome c from the mitochondria, which activates…”
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Caspase-7 Is Directly Activated by the ∼700-kDa Apoptosome Complex and Is Released as a Stable XIAP-Caspase-7 ∼200-kDa Complex by Twiddy, Davina, Cohen, Gerald M., MacFarlane, Marion, Cain, Kelvin

“…MCF-7 cells lack caspase-3 but undergo mitochondrial-dependent apoptosis via caspase-7 activation. It is assumed that the Apaf-1-caspase-9 apoptosome processes…”
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Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes by Cain, Kelvin, Bratton, Shawn B., Langlais, Claudia, Walker, Gail, Brown, David G., Sun, Xiao-Ming, Cohen, Gerald M.

“…Apaf-1, by binding to and activating caspase-9, plays a critical role in apoptosis. Oligomerization of Apaf-1, in the presence of dATP and cytochrome c, is…”
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Protein Complexes Activate Distinct Caspase Cascades in Death Receptor and Stress-Induced Apoptosis by Bratton, Shawn B., MacFarlane, Marion, Cain, Kelvin, Cohen, Gerald M.

“…Caspases play a central role in the execution phase of apoptosis and are responsible for many of the morphological features normally associated with this form…”
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