Search Results - "Cain, Gary R."

Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor by Diaz, Dolores, Ford, Kevin A., Hartley, Dylan P., Harstad, Eric B., Cain, Gary R., Achilles-Poon, Kirsten, Nguyen, Trung, Peng, Jing, Zheng, Zhong, Merchant, Mark, Sutherlin, Daniel P., Gaudino, John J., Kaus, Robert, Lewin-Koh, Sock C., Choo, Edna F., Liederer, Bianca M., Dambach, Donna M.

“…Several toxicities are clearly driven by free drug concentrations in plasma, such as toxicities related to on-target exaggerated pharmacology or off-target…”
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Phosphorous Dysregulation Induced by MEK Small Molecule Inhibitors in the Rat Involves Blockade of FGF-23 Signaling in the Kidney by Diaz, Dolores, Allamneni, Krishna, Tarrant, Jacqueline M., Lewin-Koh, Sock-Cheng, Pai, Rama, Dhawan, Preeti, Cain, Gary R., Kozlowski, Cleopatra, Hiraragi, Hajime, La, Nghi, Hartley, Dylan P., Ding, Xiao, Dean, Brian J., Bheddah, Sheila, Dambach, Donna M.

“…MEK, a kinase downstream of Ras and Raf oncogenes, constitutes a high priority target in oncology research. MEK small molecule inhibitors cause soft tissue…”
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Detrusor Myopathy in Young Beagle Dogs by Cain, Gary R., Tsai, Kuenhi, Pulley, L. Thomas, Taylor, Michael

“…Hematoxylin and eosin-stained sections of urinary bladder were examined microscopically from 449 male and female beagle dogs after 2- to 4-week toxicology…”
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Clinical and lymphohematologic responses after bone marrow transplantation in sibling and unrelated donor-recipient pairs of cats by Cain, J L, Cain, G R, Turrel, J M, Theilen, G H

“…Conditions necessary for establishment of a graft, posttransplant supportive care and complications, and lymphohematopoietic reconstitution after bone marrow…”
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Mizoribine serum levels associated with enterotoxicity in the dog by Gregory, C R, Gourley, I M, Cain, G R, Patz, J D, Imondi, K A, Martin, J A

“…To prevent or minimize mizoribine enterotoxicity in organ transplant recipients and to differentiate mizoribine enterotoxicity from other causes of enteritis,…”
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Effects of combination cyclosporine/mizoribine immunosuppression on canine renal allograft recipients by Gregory, C R, Gourley, I M, Cain, G R, Broaddus, T W, Cowgill, L D, Willits, N H, Patz, J D, Ishizaki, G

“…Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24…”
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Myasthenia gravis and polymyositis in a dog following fetal hematopoietic cell transplantation by Cain, G R, Cardinet, 3rd, G H, Cuddon, P A, Gale, R P, Champlin, R

“…Myasthenia gravis and focal polymyositis occurred in a dog following successful transplantation of DLA-identical fetal liver hematopoietic cells. There was no…”
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