Search Results - "Cain, Gary A"

Unsymmetrical 4,6-Diamino-2-methyl-5-nitropyrimidine Synthesis via 4,6-Bis(tosylates) by A. Cain, Gary, P. Beck, James

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The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase by Davis, June P, Cain, Gary A, Pitts, William J, Magolda, Ronald L, Copeland, Robert A

“…The active metabolite of leflunomide, A771726, is a novel immunosuppressive compound that has been shown to be a powerful antiproliferative agent for…”
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Total synthesis of (+)-koumine, (+)-taberpsychine, and (+)-koumidine by Magnus, Philip, Mugrage, Benjamin, DeLuca, Mark, Cain, Gary A

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Studies on Gelsemium alkaloids. Total synthesis of (+)-koumine, (+)-taberpsychine, and (+)-koumidine by Magnus, Philip, Mugrage, Benjamin, DeLuca, Mark R, Cain, Gary A

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Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands by Arvanitis, Argyrios G., Rescinito, Joseph T., Arnold, Charles R., Wilde, Richard G., Cain, Gary A., Sun, Jung Hui, Yan, Jia-Sheng, Teleha, Christopher A., Fitzgerald, Lawrence W., McElroy, John, Zaczek, Robert, Hartig, Paul R., Grossman, Scott, Arneric, Stephen P., Gilligan, Paul J., Olson, Richard E., Robertson, David W.

“…A series of high affinity CRF receptor ligands with an imidazo[4,5- b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF…”
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Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs by Gilligan, Paul J, Cain, Gary A, Christos, Thomas E, Cook, Leonard, Drummond, Spencer, Johnson, Alexander L, Kergaye, Ahmed A, McElroy, John F, Rohrbach, Kenneth W

“…sigma receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel…”
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Synthesis and in vitro antibacterial properties of alkylspectinomycin analogs by White, D R, Maring, C J, Cain, G A

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Disubstituted Indazoles as Potent Antagonists of the Integrin αvβ3 by Batt, Douglas G, Petraitis, Joseph J, Houghton, Gregory C, Modi, Dilip P, Cain, Gary A, Corjay, Martha H, Mousa, Shaker A, Bouchard, Peter J, Forsythe, Mark S, Harlow, Patricia P, Barbera, Frank A, Spitz, Susan M, Wexler, Ruth R, Jadhav, Prabhakar K

“…A new series of indazole-containing αvβ3 integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural features were…”
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Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists by Xue, Chu-Biao, Wityak, John, Sielecki, Thais M, Pinto, Donald J, Batt, Douglas G, Cain, Gary A, Sworin, Michael, Rockwell, Arlene L, Roderick, John J, Wang, Shuaige, Orwat, Michael J, Frietze, William E, Bostrom, Lori L, Liu, Jie, Higley, C. Anne, Rankin, F. Wayne, Tobin, A. Ewa, Emmett, George, Lalka, George K, Sze, Jean Y, Di Meo, Susan V, Mousa, Shaker A, Thoolen, Martin J, Racanelli, Adrienne L, Hausner, Elizabeth A, Reilly, Thomas M, DeGrado, William F, Wexler, Ruth R, Olson, Richard E

“…Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic…”
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A CONVENIENT SYNTHESIS OF N-Boc-4-FORMYLPIPERINE by Cain, Gary A., Teleha, Christopher A.

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AN IMPROVED SYNTHESIS OF 3-CYANO-4-FLUOROBENZYL BROMIDE by Cain, Gary A.

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Sequential Benzylic Oxidation of Naloxone 3-Methyl Ether by Cain, Gary A., Drummond, Spencer

“…Naloxone 3-methyl ether was selectively oxidized by treatment with cerium ammonium nitrate in aqueous acetonitrile at ambient temperature to provide the…”
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Disubstituted Indazoles as Potent Antagonists of the Integrin α v β 3 by Batt, Douglas G., Petraitis, Joseph J., Houghton, Gregory C., Modi, Dilip P., Cain, Gary A., Corjay, Martha H., Mousa, Shaker A., Bouchard, Peter J., Forsythe, Mark S., Harlow, Patricia P., Barbera, Frank A., Spitz, Susan M., Wexler, Ruth R., Jadhav, Prabhakar K.

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