Search Results - "Cain, Christopher F"

Total synthesis and chemical stability of pseudouridimycin by Cain, Christopher F, Scott, Aaron M, Sarnowski, Matthew P, Del Valle, Juan R

“…We report the chemical synthesis of pseudouridimycin (1), an antimicrobial natural product that potently and selectively inhibits bacterial RNA polymerase…”
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Synthesis of Enantiopure ε‑Oxapipecolic Acid by Howard, Evan H, Cain, Christopher F, Kang, Changwon, Del Valle, Juan R

“…A six-step synthesis of orthogonally protected (S)-ε-oxapipecolic acid is described, starting from a commercially available glutamate diester. The approach…”
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Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide‐Modified Analogues by Anwar, Avraz F., Cain, Christopher F., Garza, Michael J., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…Pseudouridimycin (PUM) is a microbially produced C‐nucleoside dipeptide that selectively targets the nucleotide addition site of bacterial RNA polymerase…”
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Front Cover: Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide‐Modified Analogues (ChemMedChem 1/2024) by Anwar, Avraz F., Cain, Christopher F., Garza, Michael J., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…The Front Cover shows a crystal structure of pseudouridimycin (PUM) bound to T. thermophilus RNA polymerase transcription complex. PUM′s inherent instability…”
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Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy by Shao, Andong, Xu, Qin, Spalek, Walker T, Cain, Christopher F, Kang, Chang Won, Tang, Chih-Hang Anthony, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor…”
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IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy by Shao, Andong, Xu, Qin, Kang, Chang Won, Cain, Christopher F., Lee, Avery C., Tang, Chih-Hang Anthony, Del Valle, Juan R., Hu, Chih-Chi Andrew

“…Activation of the IRE-1/XBP-1s pathway supports tumor progression. Here, we report a novel prodrug, TC-D-F07, in which a thiol-reactive dinitrobenzenesulfonyl…”
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Structural Tailoring of a Novel Fluorescent IRE‑1 RNase Inhibitor to Precisely Control Its Activity by Shao, Andong, Kang, Chang Won, Tang, Chih-Hang Anthony, Cain, Christopher F, Xu, Qin, Phoumyvong, Claire M, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…Activation of the IRE-1/XBP-1 pathway has been linked to many human diseases. We report a novel fluorescent tricyclic chromenone inhibitor, D-F07, in which we…”
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Synthetic studies toward eleganine A by Cain, Christopher F., Howard, Evan H., Goodwin, Justin A., Valle, Juan R. Del

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Synthesis of Biologically Relevant Compounds Harboring Unusual Hydroxamate or Proline Amino Acid Residues by Cain, Christopher F

“…Natural products are a rich source of structurally complex, medicinally potent compounds. In peptide natural products, this biological activity and complexity…”
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