Search Results - "Cain, Amy K"

Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii by Cain, Amy K, Hamidian, Mehrad

“…Antibiotic resistance is a growing global concern in the field of medicine as it renders bacterial infections difficult to treat and often more severe…”
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Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence by Semenec, Lucie, Cain, Amy K., Dawson, Catherine J., Liu, Qi, Dinh, Hue, Lott, Hannah, Penesyan, Anahit, Maharjan, Ram, Short, Francesca L., Hassan, Karl A., Paulsen, Ian T.

“…Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens frequently co-isolated from polymicrobial infections. The infections where these…”
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An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria by Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus, Cooper, Matthew A.

“…ABSTRACT Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, but they are often cationic and can be cytotoxic,…”
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Microfluidic Separation and Enrichment of Escherichia coli by Size Using Viscoelastic Flows by Zhang, Tianlong, Cain, Amy K., Semenec, Lucie, Liu, Ling, Hosokawa, Yoichiroh, Inglis, David W., Yalikun, Yaxiaer, Li, Ming

“…Here, we achieve the separation and enrichment of Escherichia coli clusters from its singlets in a viscoelastic microfluidic device. E. coli, an important…”
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High-throughput analysis of gene essentiality and sporulation in Clostridium difficile by Dembek, Marcin, Barquist, Lars, Boinett, Christine J, Cain, Amy K, Mayho, Matthew, Lawley, Trevor D, Fairweather, Neil F, Fagan, Robert P

“…Clostridium difficile is the most common cause of antibiotic-associated intestinal infections and a significant cause of morbidity and mortality. Infection…”
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DksA is a conserved master regulator of stress response in Acinetobacter baumannii by Maharjan, Ram P, Sullivan, Geraldine J, Adams, Felise G, Shah, Bhumika S, Hawkey, Jane, Delgado, Natasha, Semenec, Lucie, Dinh, Hue, Li, Liping, Short, Francesca L, Parkhill, Julian, Paulsen, Ian T, Barquist, Lars, Eijkelkamp, Bart A, Cain, Amy K

“…Abstract Coordination of bacterial stress response mechanisms is critical for long-term survival in harsh environments for successful host infection. The…”
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A synthetic peptide mimic kills Candida albicans and synergistically prevents infection by Schaefer, Sebastian, Vij, Raghav, Sprague, Jakob L., Austermeier, Sophie, Dinh, Hue, Judzewitsch, Peter R., Müller-Loennies, Sven, Lopes Silva, Taynara, Seemann, Eric, Qualmann, Britta, Hertweck, Christian, Scherlach, Kirstin, Gutsmann, Thomas, Cain, Amy K., Corrigan, Nathaniel, Gresnigt, Mark S., Boyer, Cyrille, Lenardon, Megan D., Brunke, Sascha

“…More than two million people worldwide are affected by life-threatening, invasive fungal infections annually. Candida species are the most common cause of…”
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The 3′ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions by Mediati, Daniel G., Dan, William, Lalaouna, David, Dinh, Hue, Pokhrel, Alaska, Rowell, Keiran N., Michie, Katharine A., Stinear, Timothy P., Cain, Amy K., Tree, Jai J.

“…Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are alarmingly common, and treatment is confined to last-line antibiotics. Vancomycin…”
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Length-based separation of Bacillus subtilis bacterial populations by viscoelastic microfluidics by Liu, Ping, Liu, Hangrui, Semenec, Lucie, Yuan, Dan, Yan, Sheng, Cain, Amy K., Li, Ming

“…In this study, we demonstrated the label-free continuous separation and enrichment of Bacillus subtilis populations based on length using viscoelastic…”
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A method to correct for local alterations in DNA copy number that bias functional genomics assays applied to antibiotic-treated bacteria by Sullivan, Geraldine J, Barquist, Lars, Cain, Amy K

“…Functional genomics techniques, such as transposon insertion sequencing and RNA-sequencing, are key to studying relative differences in bacterial mutant…”
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Spectrum of activity and mechanisms of azole-bisphosphonate synergy in pathogenic Candida by Kane, Aidan, Dinh, Hue, Campbell, Leona, Cain, Amy K, Hibbs, David, Carter, Dee

“…Candidiasis places a significant burden on human health and can range from common superficial vulvovaginal and oral infections to invasive diseases with high…”
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Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center by Ellington, Matthew J, Heinz, Eva, Wailan, Alexander M, Dorman, Matthew J, de Goffau, Marcus, Cain, Amy K, Henson, Sonal P, Gleadall, Nicholas, Boinett, Christine J, Dougan, Gordon, Brown, Nicholas M, Woodford, Neil, Parkhill, Julian, Török, M Estée, Peacock, Sharon J, Thomson, Nicholas R

“…Two of the most important pathogens contributing to the global rise in antimicrobial resistance (AMR) are Klebsiella pneumoniae and Enterobacter cloacae…”
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High-throughput transposon mutagenesis in the family Enterobacteriaceae reveals core essential genes and rapid turnover of essentiality by A Ghomi, Fatemeh, Jung, Jakob J, Langridge, Gemma C, Cain, Amy K, Boinett, Christine J, Abd El Ghany, Moataz, Pickard, Derek J, Kingsley, Robert A, Thomson, Nicholas R, Parkhill, Julian, Gardner, Paul P, Barquist, Lars

“…The Enterobacteriaceae are a scientifically and medically important clade of bacteria, containing the model organism , as well as major human pathogens…”
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Editorial: Secondary Effects of Antibiotic Exposure by Cain, Amy K., Nolan, Laura M., Cornick, Jennifer, Hassan, Karl A.

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A high‐resolution genomic analysis of multidrug‐resistant hospital outbreaks of Klebsiella pneumoniae by Chung The, Hao, Karkey, Abhilasha, Pham Thanh, Duy, Boinett, Christine J, Cain, Amy K, Ellington, Matthew, Baker, Kate S, Dongol, Sabina, Thompson, Corinne, Harris, Simon R, Jombart, Thibaut, Le Thi Phuong, Tu, Tran Do Hoang, Nhu, Ha Thanh, Tuyen, Shretha, Shrijana, Joshi, Suchita, Basnyat, Buddha, Thwaites, Guy, Thomson, Nicholas R, Rabaa, Maia A, Baker, Stephen

“…Multidrug‐resistant (MDR) Klebsiella pneumoniae has become a leading cause of nosocomial infections worldwide. Despite its prominence, little is known about…”
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The Transcriptomic Signature of Tigecycline in Acinetobacter baumannii by Li, Liping, Hassan, Karl A., Tetu, Sasha G., Naidu, Varsha, Pokhrel, Alaska, Cain, Amy K., Paulsen, Ian T.

“…Tigecycline, a protein translation inhibitor, is a treatment of last resort for infections caused by the opportunistic multidrug resistance human pathogen…”
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The essential genomic landscape of the commensal Bifidobacterium breve UCC2003 by Ruiz, Lorena, Bottacini, Francesca, Boinett, Christine J., Cain, Amy K., O’Connell-Motherway, Mary, Lawley, Trevor D., van Sinderen, Douwe

“…Bifidobacteria are common gut commensals with purported health-promoting effects. This has encouraged scientific research into bifidobacteria, though…”
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Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi by Feasey, Nicholas A, Cain, Amy K, Msefula, Chisomo L, Pickard, Derek, Alaerts, Maaike, Aslett, Martin, Everett, Dean B, Allain, Theresa J, Dougan, Gordon, Gordon, Melita A, Heyderman, Robert S, Kingsley, Robert A

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Defining the ABC of gene essentiality in streptococci by Charbonneau, Amelia R L, Forman, Oliver P, Cain, Amy K, Newland, Graham, Robinson, Carl, Boursnell, Mike, Parkhill, Julian, Leigh, James A, Maskell, Duncan J, Waller, Andrew S

“…Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide…”
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Breaching the Barrier: Genome-Wide Investigation into the Role of a Primary Amine in Promoting E. coli Outer-Membrane Passage and Growth Inhibition by Ampicillin by Maher, Claire, Maharjan, Ram, Sullivan, Geraldine, Cain, Amy K, Hassan, Karl A

“…Gram-negative bacteria are problematic for antibiotic development due to the low permeability of their cell envelopes. To rationally design new antibiotics…”
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