Search Results - "Cailleau, Catherine"

Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents by Dormont, Flavio, Brusini, Romain, Cailleau, Catherine, Reynaud, Franceline, Peramo, Arnaud, Gendron, Amandine, Mougin, Julie, Gaudin, Françoise, Varna, Mariana, Couvreur, Patrick

“…Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently, studies on confirmed COVID-19 cases have suggested that mortality…”
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Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder by Diaz-Salmeron, Raul, Toussaint, Balthazar, Cailleau, Catherine, Ponchel, Gilles, Bouchemal, Kawthar

“…Intravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination…”
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Assessment of Squalene-Adenosine Nanoparticles in Two Rodent Models of Cardiac Ischemia-Reperfusion by Brusini, Romain, Tran, Natalie Lan Linh, Cailleau, Catherine, Domergue, Valérie, Nicolas, Valérie, Dormont, Flavio, Calet, Serge, Cajot, Caroline, Jouran, Albin, Lepetre-Mouelhi, Sinda, Laloy, Julie, Couvreur, Patrick, Varna, Mariana

“…Reperfusion injuries after a period of cardiac ischemia are known to lead to pathological modifications or even death. Among the different therapeutic options…”
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Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of bladder painful syndrome/interstitial cystitis by Diaz-Salmeron, Raul, Cailleau, Catherine, Denis, Stéphanie, Ponchel, Gilles, Bouchemal, Kawthar

“…Glycosaminoglycan (GAG) replenishment therapy consists of the instillation of GAG solutions directly in the bladder to alleviate Bladder Painful…”
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Hyaluronan Nanoplatelets Exert an Intrinsic Antiinflammatory Activity in a Rat Model of Bladder Painful Syndrome/Interstitial Cystitis by Diaz-Salmeron, Raul, Cailleau, Catherine, Denis, Stéphanie, Ponchel, Gilles, Bouchemal, Kawthar

“…Glycosaminoglycan (GAG) replenishment therapy consists of the instillation of GAG solutions directly in the bladder to alleviate Bladder Painful…”
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Squalene-based nanoparticles for the targeting of atherosclerotic lesions by Brusini, Romain, Dormont, Flavio, Cailleau, Catherine, Nicolas, Valerie, Peramo, Arnaud, Varna, Mariana, Couvreur, Patrick

“…[Display omitted] Native low-density lipoproteins (LDL) naturally accumulate at atherosclerotic lesions and are thought to be among the main drivers of…”
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Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers by Lamaa, Diana, Cailleau, Catherine, Vergnaud, Juliette, Mougin, Julie, Bignon, Jérôme, Alami, Mouad, Fattal, Elias, Hamze, Abdallah, Tsapis, Nicolas

“…This study evaluated the potential of isoCoQ‐Carbazole, a diheterocyclic analog of isoCA‐4, as an anti‐tumor agent. To overcome its low aqueous solubility,…”
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Stability, pharmacokinetics, and biodistribution in mice of the EPAC1 inhibitor (R)-CE3F4 entrapped in liposomes and lipid nanocapsules by Toussaint, Balthazar, Hillaireau, Hervé, Cailleau, Catherine, Ambroise, Yves, Fattal, Elias

“…[Display omitted] (R)-CE3F4, a specific inhibitor of EPAC1 (exchange protein directly activated by cAMP type 1), has been demonstrated in vitro and in vivo to…”
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A nanomedicine approach for the treatment of long-lasting pain by Hazam, Hadjer, Prades, Lucas, Cailleau, Catherine, Mougin, Julie, Feng, Jiao, Benhamou, Dan, Gobeaux, Frédéric, Hamdi, Leïla, Couvreur, Patrick, Sitbon, Philippe, Lepetre-Mouelhi, Sinda

“…This study explores the potential of a nanomedicine approach, using Leu-enkephalin-squalene nanoparticles (LENK-SQ NPs) for managing long-lasting pain. It was…”
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Interspecies comparison of plasma metabolism and sample stabilization for quantitative bioanalyses: Application to (R)-CE3F4 in preclinical development, including metabolite identification by high-resolution mass spectrometry by Toussaint, Balthazar, Hillaireau, Hervé, Jaccoulet, Emmanuel, Cailleau, Catherine, Legrand, Pauline, Ambroise, Yves, Fattal, Elias

“…•Stabilization strategy against enzymatic hydrolysis in plasma samples.•Major discrepancy between human and murine plasma on (R)-CE3F4 plasmatic…”
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Pharmacokinetics, biodistribution, and activity of Amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model by Lipa Castro, Antonio, Pomel, Sébastien, Cailleau, Catherine, Fournier, Natalie, Dennemont, Indira, Loiseau, Philippe M., Barratt, Gillian

“…[Display omitted] Amphotericin B (AmB) is an effective drug to treat visceral leishmaniasis but its use is limited by its poor oral bioavailability. This…”
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Diclofenac prodrugs nanoparticles: An alternative and efficient treatment for rheumatoid arthritis? by Hussain, Saadat, Ur-Rehman, Mujeeb, Arif, Aqsa, Cailleau, Catherine, Gillet, Cynthia, Saleem, Rudaba, Noor, Hira, Naqvi, Farwa, Jabeen, Almas, Atta-ur-Rahman, Iqbal Choudhary, M., Fattal, Elias, Tsapis, Nicolas

“…[Display omitted] •Lipidic prodrugs of diclofenac were synthesized and formulated into nanoparticles with an encapsulation efficiency above 90 %.•Nanoparticles…”
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Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes by Japiassu, Kamila Bohne, Fay, Francois, Marengo, Alessandro, Louaguenouni, Younès, Cailleau, Catherine, Denis, Stéphanie, Chapron, David, Tsapis, Nicolas, Nascimento, Thais Leite, Lima, Eliana Martins, Fattal, Elias

“…Alveolar macrophages play a crucial role in the initiation and resolution of the immune response in the lungs. Pro-inflammatory M1 alveolar macrophages are an…”
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Amphiphilic Phosphorus Dendrons Associated with Anti-inflammatory siRNA Reduce Symptoms in Murine Collagen-Induced Arthritis by Yu, Zhibo, Tsapis, Nicolas, Fay, François, Chen, Liang, Karpus, Andrii, Shi, Xiangyang, Cailleau, Catherine, García Pérez, Samuel, Huang, Nicolas, Vergnaud, Juliette, Mignani, Serge, Majoral, Jean-Pierre, Fattal, Elias

“…Small interfering RNA (siRNA) holds promise for treating rheumatoid arthritis by inhibiting major cytokines such as tumor necrosis factor-α (TNF-α). We…”
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Transtympanic injection of a liposomal gel loaded with N-acetyl-L-cysteine: A relevant strategy to prevent damage induced by cochlear implantation in guinea pigs? by Jaudoin, Céline, Carré, Fabienne, Gehrke, Maria, Sogaldi, Audrey, Steinmetz, Vincent, Hue, Nathalie, Cailleau, Catherine, Tourrel, Guillaume, Nguyen, Yann, Ferrary, Evelyne, Agnely, Florence, Bochot, Amélie

“…[Display omitted] Patients with residual hearing can benefit from cochlear implantation. However, insertion can damage cochlear structures and generate…”
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A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs by Bordat, Alexandre, Boissenot, Tanguy, Ibrahim, Nada, Ferrere, Marianne, Levêque, Manon, Potiron, Léa, Denis, Stéphanie, Garcia-Argote, Sébastien, Carvalho, Olivia, Abadie, Jérôme, Cailleau, Catherine, Pieters, Grégory, Tsapis, Nicolas, Nicolas, Julien

“…Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays,…”
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Liposomal AntagomiR‐155‐5p Restores Anti‐Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis by Paoletti, Audrey, Ly, Bineta, Cailleau, Catherine, Gao, Fan, Ponfilly‐Sotier, Marie Péan, Pascaud, Juliette, Rivière, Elodie, Yang, Luxin, Nwosu, Lilian, Elmesmari, Aziza, Reynaud, Franceline, Hita, Magali, Paterson, David, Reboud, Julien, Fay, Francois, Nocturne, Gaetane, Tsapis, Nicolas, McInnes, Iain B., Kurowska‐Stolarska, Mariola, Fattal, Elias, Mariette, Xavier

“…Objective We previously reported an increased expression of microRNA‐155 (miR‐155) in the blood monocytes of patients with rheumatoid arthritis (RA) that could…”
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Transtympanic injection of a liposomal gel loaded with N-acetyl-L-cysteine: A relevant strategy to prevent damage induced by cochlear implantation in guinea pigs? by Jaudoin, Céline, Carré, Fabienne, Gehrke, Maria, Sogaldi, Audrey, Steinmetz, Vincent, Hue, Nathalie, Cailleau, Catherine, Tourrel, Guillaume, Nguyen, Yann, Ferrary, Evelyne, Agnely, Florence, Bochot, Amélie

“…Patients with residual hearing can benefit from cochlear implantation. However, insertion can damage cochlear structures and generate oxidative stress harmful…”
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Hyaluronic acid-conjugated liposomes loaded with dexamethasone: A promising approach for the treatment of inflammatory diseases by Bohne Japiassu, Kamila, Fay, Francois, Marengo, Alessandro, Mendanha, Sebastião A., Cailleau, Catherine, Louaguenouni, Younès, Wang, Qinglin, Denis, Stéphanie, Tsapis, Nicolas, Leite Nascimento, Thais, Martins Lima, Eliana, Fattal, Elias

“…[Display omitted] Dexamethasone is a well-known anti-inflammatory drug readily used to treat many lung diseases. However, its side effects and poor lower…”
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Liposomal AntagomiR‐155‐5p restores anti‐inflammatory macrophages and improves arthritis in pre‐clinical models of Rheumatoid arthritis by Paoletti, Audrey, Ly, Bineta, Cailleau, Catherine, Gao, Fan, Péan de Ponfilly-Sotier, Marie, Pascaud, Juliette, Rivière, Elodie, Yang, Luxin, Nwosu, Lilian, Elmesmari, Aziza, Reynaud, Franceline, Hita, Magali, Paterson, David, Reboud, Julien, Fay, Francois, Nocturne, Gaetane, Tsapis, Nicolas, Mcinnes, Iain B, Kurowska-Stolarska, Mariola, Fattal, Elias, Mariette, Xavier

“…Introduction We previously reported an increased expression of miR‐155 in rheumatoid arthritis (RA) patients blood monocytes that could be responsible for…”
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