Search Results - "Cai, Zhongling"

The genomic landscape of core-binding factor acute myeloid leukemias by Faber, Zachary J, Chen, Xiang, Gedman, Amanda Larson, Boggs, Kristy, Cheng, Jinjun, Ma, Jing, Radtke, Ina, Chao, Jyh-Rong, Walsh, Michael P, Song, Guangchun, Andersson, Anna K, Dang, Jinjun, Dong, Li, Liu, Yu, Huether, Robert, Cai, Zhongling, Mulder, Heather, Wu, Gang, Edmonson, Michael, Rusch, Michael, Qu, Chunxu, Li, Yongjin, Vadodaria, Bhavin, Wang, Jianmin, Hedlund, Erin, Cao, Xueyuan, Yergeau, Donald, Nakitandwe, Joy, Pounds, Stanley B, Shurtleff, Sheila, Fulton, Robert S, Fulton, Lucinda L, Easton, John, Parganas, Evan, Pui, Ching-Hon, Rubnitz, Jeffrey E, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Mullighan, Charles G, Schlenk, Richard F, Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Bullinger, Lars, Zhang, Jinghui, Klco, Jeffery M, Downing, James R

“…Lars Bullinger, Jinghui Zhang, Jeffery Klco, James Downing and colleagues report a detailed genomic analysis of pediatric and adult core-binding factor acute…”
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Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia by Radtke, Ina, Mullighan, Charles G, Ishii, Masami, Su, Xiaoping, Cheng, Jinjun, Ma, Jing, Ganti, Ramapriya, Cai, Zhongling, Goorha, Salil, Pounds, Stanley B, Cao, Xueyuan, Obert, Caroline, Armstrong, Jianling, Zhang, Jinghui, Song, Guangchun, Ribeiro, Raul C, Rubnitz, Jeffrey E, Raimondi, Susana C, Shurtleff, Sheila A, Downing, James R

“…Pediatric de novo acute myeloid leukemia (AML) is an aggressive malignancy with current therapy resulting in cure rates of only 60%. To better understand the…”
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Haploinsufficiency of AML1 Affects the Temporal and Spatial Generation of Hematopoietic Stem Cells in the Mouse Embryo by Cai, Zhongling, de Bruijn, Marella, Ma, Xiaoqian, Dortland, Bjorn, Luteijn, Tanya, Downing, James R, Dzierzak, Elaine

“…The AML1:CBFβ transcription factor complex is essential for definitive hematopoiesis. Null mutations in mouse AML1 result in midgestational lethality with a…”
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Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors by Okuda, Tsukasa, Cai, Zhongling, Yang, Shouli, Lenny, Noel, Lyu, Chuhl-joo, van Deursen, Jan M.A., Harada, Hironori, Downing, James R.

“…The t(8;21)-encoded AML1-ETO chimeric product is believed to be causally involved in up to 15% of acute myelogenous leukemias through an as yet unknown…”
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The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes by Huether, Robert, Dong, Li, Chen, Xiang, Wu, Gang, Parker, Matthew, Wei, Lei, Ma, Jing, Edmonson, Michael N., Hedlund, Erin K., Rusch, Michael C., Shurtleff, Sheila A., Mulder, Heather L., Boggs, Kristy, Vadordaria, Bhavin, Cheng, Jinjun, Yergeau, Donald, Song, Guangchun, Becksfort, Jared, Lemmon, Gordon, Weber, Catherine, Cai, Zhongling, Dang, Jinjun, Walsh, Michael, Gedman, Amanda L., Faber, Zachary, Easton, John, Gruber, Tanja, Kriwacki, Richard W., Partridge, Janet F., Ding, Li, Wilson, Richard K., Mardis, Elaine R., Mullighan, Charles G., Gilbertson, Richard J., Baker, Suzanne J., Zambetti, Gerard, Ellison, David W., Zhang, Jinghui, Downing, James R.

“…Studies of paediatric cancers have shown a high frequency of mutation across epigenetic regulators. Here we sequence 633 genes, encoding the majority of known…”
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IDH1 and IDH2 mutations in pediatric acute leukemia by Andersson, A K, Miller, D W, Lynch, J A, Lemoff, A S, Cai, Z, Pounds, S B, Radtke, I, Yan, B, Schuetz, J D, Rubnitz, J E, Ribeiro, R C, Raimondi, S C, Zhang, J, Mullighan, C G, Shurtleff, S A, Schulman, B A, Downing, J R

“…To investigate the frequency of isocitrate dehydrogenase 1 ( IDH1 ) and 2 ( IDH2 ) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid…”
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Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors by OKUDA, T, ZHONGLING CAI, SHOULI YANG, LENNY, N, LYU, C.-J, VAN DEURSEN, J. M. A, HARADA, H, DOWNING, J. R

“…The t(8;21)-encoded AML1-ETO chimeric product is believed to be causally involved in up to 15% of acute myelogenous leukemias through an as yet unknown…”
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IDH1 and IDH2 Mutations In Pediatric Acute Myeloid Leukemia by Andersson, Anna, Miller, David, Lynch, John, Lemoff, Andrew, Cai, Zhongling, Pounds, Stanley, Radtke, Ina, Bing, Yan, John, Schuetz, Jeffrey, Rubnitz, Ribeiro, Raul, Raimondi, Susana C., Zhang, Jinghui, Shurtleff, Sheila, Schulman, Brenda, Downing, James

“…Abstract 1699 Pediatric de novo acute myeloid leukemia (AML) is a heterogeneous disease that can be divided into clinically distinct subtypes based on the…”
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Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia by Mullighan, Charles G, Radtke, Ina, Zhang, Jinghui, Phillips, Letha A., Su, Xiaoping, Ma, Jing, Cai, Zhongling, Hughes, Timothy P., White, Deborah L, Roberts, Andrew W., Campbell, Lynda J., Shurtleff, Sheila A., Downing, James R.

“…Expression of BCR-ABL1 is the hallmark of chronic myelogenous leukemia (CML) and a subset of de novo acute lymphoblastic leukemia (ALL), but the factors…”
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Genomic Analysis Reveals Few Genetic Alterations in Pediatrie Acute Myeloid Leukemia by Radtke, Ina, Mullighan, Charles G., Ishii, Masami, Su, Xiaoping, Cheng, Jinjun, Ma, Jing, Ganti, Ramapriya, Cai, Zhongling, Goorha, Salii, Pounds, Stanley B., Cao, Xueyuan, Obert, Caroline, Armstrong, Jianling, Zhang, Jinghui, Song, Guangchun, Ribeiro, Raul C., Rubnitz, Jeffrey E., Raimondi, Susana C., Shurtleff, Sheila A., Downing, James R., Rowley, Janet D.

“…Pediatrie de novo acute myeloid leukemia (AML) is an aggressive malignancy with current therapy resulting in cure rates of only 60%. To better understand the…”
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Tolerance of Chinese milkvetch (Astragalus sinicus) to herbicides by Cai, Z.L. (Wash. State Univ., Pullman, WA), Brauen, S.E, Gealy, D.R, Johnston, W.J, Lumpkin, T.A

“…Chinese milkvetch is the most important green manure crop in the rice producing regions of China. The tolerance of Chinese milkvetch to 29 herbicides approved…”
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High-Resolution Genome-Wide Profiling of DNA Copy Number Abnormalities and Gene Resequencing in Pediatric Acute Myeloid Leukemia (AML) by Radtke, Ina, Mullighan, Charles G., Ishii, Masami, Ma, Jing, Su, Xiaoping, Goorha, Salil, Ganti, Ramapriya, Cai, Zhongling, Phillips, Letha A., Pounds, Stanley B., Dalton, James, Raimondi, Susana C., Rubnitz, Jeffrey E., Ribeiro, Raul C., Shurtleff, Sheila A., Downing, James R.

“…To define the complement of genetic lesions in pediatric AML, we performed high resolution genome-wide analysis on bone marrow blasts from 111 cases using…”
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The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes by Huether, Robert, Dong, Li, Chen, Xiang, Wu, Gang, Parker, Matthew, Wei, Lei, Ma, Jing, Edmonson, Michael N., Hedlund, Erin K., Rusch, Michael C., Shurtleff, Sheila A., Mulder, Heather L., Boggs, Kristy, Vadordaria, Bhavin, Cheng, Jinjun, Yergeau, Donald, Song, Guangchun, Becksfort, Jared, Lemmon, Gordon, Weber, Catherine, Cai, Zhongling, Dang, Jinjun, Walsh, Michael, Gedman, Amanda L., Faber, Zachary, Easton, John, Gruber, Tanja, Kriwacki, Richard W., Partridge, Janet F., Ding, Li, Wilson, Richard K., Mardis, Elaine R., Mullighan, Charles G., Gilbertson, Richard J., Baker, Suzanne J., Zambetti, Gerard, Ellison, David W., Zhang, Jinghui, Downing, James R.

“…Here we sequence 633 genes, encoding the majority of known epigenetic regulatory proteins, in over 1000 pediatric tumors to define the landscape of somatic…”
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