Search Results - "Cai, Zhiyou"

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer's disease (Review) by CAI, ZHIYOU

“…Activated monoamine oxidase (MAO) has a critical role in the pathogenesis of Alzheimer's disease (AD), including the formation of amyloid plaques from amyloid…”
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Role of AMPK in autophagy by Wang, Shengyuan, Li, Hongyan, Yuan, Minghao, Fan, Haixia, Cai, Zhiyou

“…Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly…”
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Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis by Zhang, Lan, Hu, Weishu, Cai, Zhiyou, Liu, Jihong, Wu, Jianmei, Deng, Yangmin, Yu, Keping, Chen, Xiaohua, Zhu, Li, Ma, Jingxi, Qin, Yan

“…Physical therapy can prevent functional impairments and improve the quality of life of patients after hospital discharge. However, the effect of early…”
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Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation by Jing, Feng, Zou, Qian, Wang, Yangyang, Cai, Zhiyou, Tang, Yong

“…Background Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus…”
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Role of Blood-Brain Barrier in Alzheimer's Disease by Cai, Zhiyou, Qiao, Pei-Feng, Wan, Cheng-Qun, Cai, Min, Zhou, Nan-Kai, Li, Qin

“…The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD). BBB is a highly selective semipermeable structural and chemical…”
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Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes by Yuan, Chan, Gao, Junying, Guo, Jichao, Bai, Lei, Marshall, Charles, Cai, Zhiyou, Wang, Linmei, Xiao, Ming

“…Dimethyl sulfoxide (DMSO) is a polar organic solvent that is used to dissolve neuroprotective or neurotoxic agents in neuroscience research. However, DMSO…”
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Volume of white matter hyperintensities increases with blood pressure in patients with hypertension by Zhao, Yu, Ke, Zunyu, He, Wenbo, Cai, Zhiyou

“…Objective Hypertension is a risk factor for development of white matter hyperintensities (WMHs). However, the relationship between hypertension and WMHs…”
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Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment by Wei, Shouchao, Peng, Wanjuan, Mai, Yingren, Li, Kanglan, Wei, Wei, Hu, Li, Zhu, Shaoping, Zhou, Haihong, Jie, Wanxin, Wei, Zhuangsheng, Kang, Chenyao, Li, Ruikai, Liu, Zhou, Zhao, Bin, Cai, Zhiyou

“…Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well‐known to be involved in the pathological process of…”
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Roles of glycogen synthase kinase 3 in Alzheimer's disease by Cai, Zhiyou, Zhao, Yu, Zhao, Bin

“…Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and…”
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Ameliorating Alzheimers-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling by Zhao, Yu, Wang, Chuanling, He, Wenbo, Cai, Zhiyou

“…Background: Minocycline has multiple neuroprotective roles in abundant brain diseases, including the prevention and treatment of Alzheimers disease (AD)…”
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Dietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway by Yang, Xu, Liu, Shu, Wang, Chuanling, Fan, Haixia, Zou, Qian, Pu, Yingshuang, Cai, Zhiyou

“…Dietary salt has been associated with cognitive impairment in mice, possibly related to damaged synapses and tau hyperphosphorylation. However, the mechanism…”
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Berberine Rescues D-Ribose-Induced Alzheimer‘s Pathology via Promoting Mitophagy by Wang, Chuanling, Zou, Qian, Pu, Yinshuang, Cai, Zhiyou, Tang, Yong

“…Mitochondrial dysfunction is considered an early event of Alzheimer disease (AD). D-ribose is a natural monosaccharide that exists in cells, especially in…”
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Status epilepticus with focal neurologic deficits: a rare presentation of Neurosyphilis by Qi, Yunwen, Jiang, Zongze, Xie, Daixin, Lei, Na, Cai, Zhiyou

“…•Neurosyphilis can occur at any time as a late complication of primary syphilis and present with a multitude of symptoms.•Status epilepticus and focal…”
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Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease? by Cai, Zhiyou, Zhao, Bin, Li, Keshen, Zhang, Liangqing, Li, Chunhua, Quazi, Sohel H., Tan, Yan

“…Autophagy plays a critical role in multiple pathological lesions of Alzheimer's disease (AD), such as the formation of amyloid plaques from amyloid‐β (Aβ)…”
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Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease by Sun, Yan, Zhang, Huaiwu, Zhang, Xuan, Wang, Wenzhao, Chen, Yong, Cai, Zhiyou, Wang, Qihui, Wang, Jun, Shi, Yi

“…The brain is particularly susceptible to oxidative damage which is a key feature of several neurodegenerative diseases, including Alzheimer's disease (AD),…”
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Isolated unilateral brachial plexus injury following carbon monoxide intoxication: a case report and literature review by Liu, Shu, Sun, Houchao, Wang, Shengyuan, Liao, Jincheng, Yang, Xu, Cai, Zhiyou

“…Carbon monoxide (CO) is a gas that has no odor or color, making it difficult to detect until exposure leads to coma or death. CO poisoning is one of the most…”
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Roles of AMP-activated Protein Kinase in Alzheimer’s Disease by Cai, Zhiyou, Yan, Liang-Jun, Li, Keshen, Quazi, Sohel H., Zhao, Bin

“…AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis and a central player in glucose and lipid metabolism, is potentially…”
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Role of angiotensin II in aging by Yi, Wenmin, Chen, Fei, Zhang, Huiji, Tang, Peng, Yuan, Minghao, Wen, Jie, Wang, Shengyuan, Cai, Zhiyou

“…Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin-angiotensin system (RAS)…”
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Enriched oxygen improves age-related cognitive impairment through enhancing autophagy by Wang, Shengyuan, Chen, Bengang, Yuan, Minghao, Liu, Shu, Fan, Haixia, Yang, Xu, Zou, Qian, Pu, Yinshuang, Cai, Zhiyou

“…Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being…”
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Activation of mTOR: a culprit of Alzheimer's disease? by Cai, Zhiyou, Chen, Guanghui, He, Wenbo, Xiao, Ming, Yan, Liang-Jun

“…Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation, and by β-amyloid (Aβ) production and the hyper-phosphorylation of…”
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