Search Results - "Cai, Zhiming"

Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells by Liu, Yuchen, Huang, Weiren, Cai, Zhiming

“…The logical AND gate gene circuit based on the CRISPR-Cas9 system can distinguish bladder cancer cells from normal bladder epithelial cells. However, the…”
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Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells by Liu, Yuchen, Zeng, Yayue, Liu, Li, Zhuang, Chengle, Fu, Xing, Huang, Weiren, Cai, Zhiming

“…The conventional strategy for cancer gene therapy offers limited control of specificity and efficacy. A possible way to overcome these limitations is to…”
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Statistical analysis of tourist flow in tourist spots based on big data platform and DA-HKRVM algorithms by Li, Daming, Deng, Lianbing, Cai, Zhiming

“…In the context of economic globalization, the rapid transmission of network information, people’s attention to tourism culture perspective has changed…”
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Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder by Han, Yonghua, Liu, Yuchen, Gui, Yaoting, Cai, Zhiming

“…Background and Objectives Long intergenic non‐coding RNAs (lincRNAs) are a class of non‐coding RNAs that regulate gene expression via chromatin reprogramming…”
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Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer by Wu, Song, Ou, Tong, Xing, Nianzeng, Lu, Jiang, Wan, Shengqing, Wang, Changxi, Zhang, Xi, Yang, Feiya, Huang, Yi, Cai, Zhiming

“…Bladder cancer is one of the most common and highly vascularized cancers. To better understand its genomic structure and underlying etiology, we conduct…”
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Clonal architectures predict clinical outcome in clear cell renal cell carcinoma by Huang, Yi, Wang, Jiayin, Jia, Peilin, Li, Xiangchun, Pei, Guangsheng, Wang, Changxi, Fang, Xiaodong, Zhao, Zhongming, Cai, Zhiming, Yi, Xin, Wu, Song, Zhang, Baifeng

“…The genetic landscape of clear cell renal cell carcinoma (ccRCC) had been investigated extensively but its evolution patterns remained unclear. Here we analyze…”
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Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis by Zhang, Xiaoli, Zhu, Xinyue, Wang, Caihong, Zhang, Haixia, Cai, Zhiming

“…Lung cancer is the most common cause of cancer death in China. We characterized metabolic alterations in lung cancer using two analytical platforms: a…”
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Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1 by Han, Yonghua, Liu, Yuchen, Zhang, Hu, Wang, Tiantian, Diao, Ruiying, Jiang, Zhimao, Gui, Yaoting, Cai, Zhiming

“…•Hsa-miR-125b and SIRT7/MALAT1 are inversely expressed in bladder cancer.•Hsa-miR-125b inhibits bladder cancer cell growth and motility, and increases…”
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Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder by Han, Yonghua, Liu, Yuchen, Nie, Liping, Gui, Yaoting, Cai, Zhiming

“…Objective To study the expression patterns of long noncoding ribonucleic acid (RNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the…”
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Directing cellular information flow via CRISPR signal conductors by Liu, Yuchen, Zhan, Yonghao, Chen, Zhicong, He, Anbang, Li, Jianfa, Wu, Hanwei, Liu, Li, Zhuang, Chengle, Lin, Junhao, Guo, Xiaoqiang, Zhang, Qiaoxia, Huang, Weiren, Cai, Zhiming

“…The integration of ligand-responsive riboswitches with single guide RNAs allows Cas9–effector fusions to be targeted in response to ligands and thereby…”
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Metabolic characterization of asthenozoospermia using nontargeted seminal plasma metabolomics by Zhang, Xiaoli, Diao, Ruiying, Zhu, Xinyue, Li, Zesong, Cai, Zhiming

“…Asthenozoospermia (AS) is a common cause of male infertility. Due to the limitation of routine semen analysis, metabolic alterations associated with the…”
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Improved pitch shifting data augmentation for ship-radiated noise classification by Yuanchao, Xu, Zhiming, Cai, Xiaopeng, Kong

“…•An improved pitch shifting data augmentation method is proposed.•Improved pitch shifting outperforms other augmentation on DeepShip and ShipsEar.•Using…”
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Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules by Wang, Ziqiang, Li, Kun, Chen, Wei, Wang, Xiaoxia, Huang, Yikun, Wang, Weiming, Wu, Wanjun, Cai, Zhiming, Huang, Weiren

“…The elevated expression of immune checkpoints by the tumor microenvironment is associated with poor prognosis in several cancers due to the exhaustion of…”
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Single-cell Sequencing Reveals Variants in ARID1A , GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells by Yang, Zhao, Li, Chong, Liu, Hongjie, Zhang, Xiaolong, Cai, Zhiming, Xu, Liqin, Luo, Jian, Huang, Yi, He, Luyun, Liu, Chunxiao, Wu, Song

“…Abstract Cancer stem cells are considered responsible for many important aspects of tumors such as their self-renewal, tumor-initiating, drug-resistance and…”
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Fluid-structure interaction simulation of dynamic response and wake of floating offshore wind turbine considering tower shadow effect by Liu, Songyang, Xin, Zhiqiang, Wang, Lei, Cai, Zhiming

“…The comprehensive numerical simulation of the tower shadow effect on floating offshore wind turbines (FOWTs), an area less explored compared to fixed-bottom…”
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Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future by Liu, Zhengzhao, Hu, Wenbao, He, Tian, Dai, Yifan, Hara, Hidetaka, Bottino, Rita, Cooper, David K. C., Cai, Zhiming, Mou, Lisha

“…Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet…”
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Predicting coastal urban floods using artificial neural network: The case study of Macau, China by Dai, Weijun, Cai, Zhiming

“…Using data-driven models to predict floods in advance is one of the current effective methods and hot researches to reduce urban flood disasters. In order to…”
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A Frequency–Azimuth Spectrum Estimation Method for Uniform Linear Array Based on Deconvolution by Lu, Daiqiang, Cai, Zhiming, Guo, Wei, Yao, Zhixiang, Cao, Huanzhi

“…The frequency–azimuth (FRAZ) spectrum is a critical characteristic in passive target detection and tracking, as it encapsulates information regarding the…”
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The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line by Palsson, Bernhard O, Wang, Jun, Xu, Xun, Nagarajan, Harish, Lewis, Nathan E, Pan, Shengkai, Cai, Zhiming, Liu, Xin, Chen, Wenbin, Xie, Min, Wang, Wenliang, Hammond, Stephanie, Andersen, Mikael R, Neff, Norma, Passarelli, Benedetto, Koh, Winston, Fan, H Christina, Wang, Jianbin, Gui, Yaoting, Lee, Kelvin H, Betenbaugh, Michael J, Quake, Stephen R, Famili, Iman

“…Since 1987, immortalized cells from the ovary of a Chinese hamster have been the workhorse for producing recombinant therapeutics, including monoclonal…”
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Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma by Zhou, Liang, Chen, Jiahao, Li, Zhizhong, Li, Xianxin, Hu, Xueda, Huang, Yi, Zhao, Xiaokun, Liang, Chaozhao, Wang, Yong, Sun, Liang, Shi, Min, Xu, Xiaohong, Shen, Feng, Chen, Maoshan, Han, Zujing, Peng, Zhiyu, Zhai, Qingna, Chen, Jing, Zhang, Zhongfu, Yang, Ruilin, Ye, Jiongxian, Guan, Zhichen, Yang, Huanming, Gui, Yaoting, Wang, Jun, Cai, Zhiming, Zhang, Xiuqing

“…With the advent of second-generation sequencing, the expression of gene transcripts can be digitally measured with high accuracy. The purpose of this study was…”
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