Search Results - "Cai, Wenchen"

Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway by Li, Yaqian, Cai, Wenchen, Jin, Fuyu, Wang, Xiaojing, Liu, Wenjing, Li, Tian, Yang, Xinyu, Liu, Heliang, Xu, Hong, Yang, Fang

“…Silicosis is the most prevalent occupational disease in China. It is a form of pulmonary fibrosis caused by the inhalation of silicon particles. As there is no…”
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Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion by Zhang, Chuanxi, Kang, Yumeng, Zhang, Ziyan, Liu, Heliang, Xu, Hong, Cai, Wenchen, Gao, Xuemin, Yang, Jie

“…Rosacea is a chronic inflammatory skin disease whose late manifestations have not yet been clearly reported in animal models. The objective of this study is to…”
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Oxamate Attenuates Glycolysis and ER Stress in Silicotic Mice by Mao, Na, Fan, Yuhang, Liu, Wenjing, Yang, Honghao, Yang, Yi, Li, Yaqian, Jin, Fuyu, Li, Tian, Yang, Xinyu, Gao, Xuemin, Cai, Wenchen, Liu, Heliang, Xu, Hong, Li, Shifeng, Yang, Fang

“…Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis and ER stress are…”
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Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1 by Cai, Wenchen, Xu, Hong, Zhang, Bonan, Gao, Xuemin, Li, Shumin, Wei, Zhongqiu, Li, Shifeng, Mao, Na, Jin, Fuyu, Li, Yaqian, Liu, Heliang, Yang, Fang

“…[Display omitted] •A total of 306 LncRNAs were altered in a chronic silicotic model.•Several LncRNAs had similar changes in TGF-β1-treated lung…”
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Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway by Geng, Fei, Zhao, Lan, Cai, Yuhao, Zhao, Ying, Jin, Fuyu, Li, Yaqian, Li, Tian, Yang, Xinyu, Li, Shifeng, Gao, Xuemin, Cai, Wenchen, Mao, Na, Sun, Ying, Xu, Hong, Wei, Zhongqiu, Yang, Fang

“…Silicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and…”
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Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling by Gao, Xuemin, Xu, Dingjie, Li, Shumin, Wei, Zhongqiu, Li, Shifeng, Cai, Wenchen, Mao, Na, Jin, Fuyu, Li, Yaqian, Yi, Xue, Liu, Heliang, Xu, Hong, Yang, Fang

“…To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on the expression of microRNAs…”
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Quercetin Alleviates Pulmonary Fibrosis in Mice Exposed to Silica by Inhibiting Macrophage Senescence by Geng, Fei, Xu, Mengying, Zhao, Lan, Zhang, Haoming, Li, Jiarui, Jin, Fuyu, Li, Yaqian, Li, Tian, Yang, Xinyu, Li, Shifeng, Gao, Xuemin, Cai, Wenchen, Mao, Na, Sun, Ying, Liu, Heliang, Xu, Hong, Wei, Zhongqiu, Yang, Fang

“…Quercetin exerts anti-inflammatory, anti-oxidant and other protective effects. Previous studies have shown that senescent cells, such as fibroblasts and type…”
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Regulatory effect of integrated stress response inhibitors on endoplasmic reticulum stress signals in macrophages in silicotic mice by Li, Yaqian, An, Xuliang, Bai, Yifei, Liu, Yang, Gao, Xuemin, Cai, Wenchen, Xu, Hong, Yang, Fang

“…[Background] Silicosis is one of the most serious occupational diseases in China, requiring new treatment targets and therapies. The effects and mechanisms of…”
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Intervention effect of physical exercise on silicotic mice by Jin, Fuyu, Wang, Xiaojing, Liu, Wenjing, Li, Yaqian, Gao, Xuemin, Cai, Wenchen, Mao, Na, Liu, Heliang

“…Background Pneumoconiosis is the most serious occupational disease in China, and silicosis accounts for about half of it. Any intervention effect of physical…”
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Minute Cellular Nodules as Early Lesions in Rats with Silica Exposure via Inhalation by Li, Yaqian, Jin, Fuyu, Li, Tian, Yang, Xinyu, Cai, Wenchen, Li, Shifeng, Gao, Xuemin, Mao, Na, Liu, Heliang, Xu, Hong, Yang, Fang

“…Mechanisms of silicosis have yet to be clarified, and pathological conditions are inaccurately described in some experimental studies on silicosis. This study…”
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Recent progress on performance-enhancing strategies in flexible photodetectors: From structural engineering to flexible integration by Wang, Pu, Lan, Yingying, Huan, Changmeng, Luo, Jilong, Cai, Wenchen, Fan, Juntian, He, Xinjun, Huang, Zhanfeng, Zhu, Lu, Ke, Qingqing, Zhang, Guangyu, Lin, Shenghuang

“…As an important component of future electronic devices, photodetectors require mechanical flexibility, and stretchability to meet the demands of conformal,…”
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IL‐17A‐neutralizing antibody ameliorates inflammation and fibrosis in rosacea by antagonizing the CXCL5/CXCR2 axis by Zhang, Chuanxi, Jin, Hui, Kang, Yumeng, Wu, Yiling, Zheng, Ruiping, Zhang, Ziyan, Xu, Hong, Cai, Wenchen, Gao, Xuemin, Liu, Heliang, Mao, Na, Yang, Jie

“…Rosacea is a chronic inflammatory skin disorder that can lead to fibrosis. However, the mechanisms underlying fibrosis in the later stages of rosacea have been…”
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Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica by Jin, Fuyu, Li, Yaqian, Gao, Xuemin, Yang, Xinyu, Li, Tian, Liu, Shupeng, Wei, Zhongqiu, Li, Shifeng, Mao, Na, Liu, Heliang, Cai, Wenchen, Xu, Hong, Zhang, Haibo

“…Exposure to crystalline silica leads to health effects beyond occupational silicosis. Exercise training's potential benefits on pulmonary diseases yield…”
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Ac-SDKP increases α-TAT 1 and promotes the apoptosis in lung fibroblasts and epithelial cells double-stimulated with TGF-β1 and silica by Shifeng, Li, Hong, Xu, Xue, Yi, Siyu, Niu, Qiaodan, Zhang, Dingjie, Xu, Lijuan, Zhang, Zhongqiu, Wei, Xuemin, Gao, Wenchen, Cai, Guizhen, Zhang, Dan, Li, Ruimin, Wang, Fang, Yang

“…Crystalline silica (SiO2) particles have very strong toxicity to the lungs, and silicosis is an excessive pulmonary interstitial remodeling disease that…”
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MiR-411–3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling by Gao, Xuemin, Xu, Hong, Xu, Dingjie, Li, Shumin, Wei, Zhongqiu, Li, Shifeng, Cai, Wenchen, Mao, Na, Jin, Fuyu, Li, Yaqian, Li, Tian, Yi, Xue, Liu, Heliang, Yang, Fang

“…Occupational exposure to silica dust particles was the major cause of pulmonary fibrosis, and many miRNAs have been demonstrated to regulate target mRNAs in…”
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Matrix stiffness regulates α-TAT1-mediated acetylation of α-tubulin and promotes silica-induced epithelial-mesenchymal transition via DNA damage by Li, Gengxu, Chen, Si, Zhang, Yi, Xu, Hong, Xu, Dingjie, Wei, Zhongqiu, Gao, Xuemin, Cai, Wenchen, Mao, Na, Zhang, Lijuan, Li, Shumin, Yang, Fang, Liu, Heliang, Li, Shifeng

“…Silicosis is characterized by silica exposure-induced lung interstitial fibrosis and formation of silicotic nodules, resulting in lung stiffening. The…”
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Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats by Cai, Wenchen, Zhang, Bonan, Li, Tian, Jin, Fuyu, Li, Yaqian, Xu, Hong, Yang, Fang

“…Silicosis is caused by exposure to crystalline silica and the molecular mechanism of silicotic fibrosis remains unclear. Therefore, the present study…”
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Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models by Li, Tian, Mao, Na, Xie, Zihao, Wang, Jianing, Jin, Fuyu, Li, Yaqian, Liu, Shupeng, Cai, Wenchen, Gao, Xuemin, Wei, Zhongqiu, Yang, Fang, Xu, Hong, Liu, Heliang, Zhang, Haibo, Xu, Dingjie

“…Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue…”
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MicroRNA‐411‐3p inhibits bleomycin‐induced skin fibrosis by regulating transforming growth factor‐β/Smad ubiquitin regulatory factor‐2 signalling by Zhang, Ziyan, Gao, Xuemin, He, Yang, Kang, Yumeng, Jin, Fuyu, Li, Yaqian, Li, Tian, Wei, Zhongqiu, Li, Shifeng, Cai, Wenchen, Mao, Na, Wang, Shan, Liu, Heliang, Yang, Fang, Xu, Hong, Yang, Jie

“…Skin fibrosis, which is characterized by fibroblast proliferation and increased extracellular matrix, has no effective treatment. An increasing number of…”
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Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling by Wei, Zhongqiu, Xu, Hong, Zhang, Yi, Yi, Xue, Yang, Xinyu, Chen, Yingying, Mao, Na, Li, Shifeng, Xu, Dingjie, Li, Shumin, Zhang, Hui, Li, Dan, Zhang, Guizhen, Zhang, Bonan, Jin, Fuyu, Gao, Xuemin, Cai, Wenchen, Zhang, Lijuan, Wang, Ruimin, Yang, Fang

“…Transforming growth factor-β1 (TGF-β1) alters the fibroblast phenotype by promoting transdifferentiation into myofibroblasts, which exhibit the ability to…”
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