Search Results - "Cai, Shurui"
-
1
Inhibition of miR-328-3p Impairs Cancer Stem Cell Function and Prevents Metastasis in Ovarian Cancer
Published in Cancer research (Chicago, Ill.) (01-05-2019)“…Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important in regulating CSC properties and are…”
Get full text
Journal Article -
2
Identification of Rhizospheric Actinomycete Streptomyces lavendulae SPS-33 and the Inhibitory Effect of its Volatile Organic Compounds against Ceratocystis Fimbriata in Postharvest Sweet Potato ( Ipomoea Batatas (L.) Lam.)
Published in Microorganisms (Basel) (25-02-2020)“…Black spot disease, which is caused by the pathogenic fungal , seriously affects the production of sweet potato and its quality during postharvest storage. In…”
Get full text
Journal Article -
3
ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression
Published in NPJ precision oncology (10-07-2023)“…Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous…”
Get full text
Journal Article -
4
Expression, Purification and Antibacterial Activity of NK-Lysin Mature Peptides from the Channel Catfish (Ictalurus punctatus)
Published in Applied sciences (01-01-2016)“…Antimicrobial peptides (AMPs) are small peptides and play important roles in host innate immune response against microbial invasion. Aquatic animals secrete…”
Get full text
Journal Article -
5
Abstract 3094: Estrogen receptor β agonist depletes ovarian cancer stem cells via repressing epithelial to mesenchymal transition
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Ovarian cancer is considered a hormone sensitive tumor. A healthy ovary expresses both Estrogen Receptors alpha (ERα) and beta (ERβ). However,…”
Get full text
Journal Article -
6
Abstract 3104: EMT and CSC Enrichment Induced by ERK Inhibition in NSCLC
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract The activation of Mitogen-activated protein kinase pathway (MAPK/ERK pathway) has been found to play an important role in many cancers including lung…”
Get full text
Journal Article -
7
Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor
Published in Journal of medicinal chemistry (09-09-2021)“…The Ras subfamily of small GTPases is mutated in ∼30% of human cancers and represents compelling yet challenging anticancer drug targets owing to their flat…”
Get full text
Journal Article -
8
ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2 -/- Ovarian Cancer Cells
Published in Molecular cancer therapeutics (01-01-2020)“…Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved to treat recurrent ovarian cancer with or mutations, and as maintenance therapy for…”
Get full text
Journal Article -
9
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
Published in Molecular cell (07-04-2022)“…Synthetic lethality through combinatorial targeting DNA damage response (DDR) pathways provides exciting anticancer therapeutic benefit. Currently, the long…”
Get full text
Journal Article -
10
Determination of DNA lesion bypass using a ChIP-based assay
Published in DNA repair (01-12-2021)“…DNA lesion bypass facilitates DNA synthesis across bulky DNA lesions, playing a critical role in DNA damage tolerance and cell survival after DNA damage…”
Get full text
Journal Article -
11
Abstract 3691: XPC inhibits lung cancer cell dedifferentiation by suppressing Snail expression
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Lung cancer remains a leading cause of cancer-related deaths in the United States with unfavorable prognosis mainly due to tumor relapse and…”
Get full text
Journal Article -
12
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Published in Nature (London) (23-05-2024)“…RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at…”
Get full text
Journal Article -
13
Abstract NT-100: PARPI-INDUCED ALDH1A1 EXPRESSION CONTRIBUTES TO PARPI RESISTANCE IN OVARIAN CANCER CELLS
Published in Clinical cancer research (15-11-2019)“…Abstract Ovarian cancer (OC) is one of the most lethal female malignancy which accounts for just 2.5% of female cancer cases but 5% of deaths because of low…”
Get full text
Journal Article -
14
PP2A B55α inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer
Published in Cancer letters (28-08-2024)“…PP2A B55α, encoded by PPP2R2A, acts as a regulatory subunit of the serine/threonine phosphatase PP2A. Despite a frequent loss of heterozygosity of PPP2R2A in…”
Get full text
Journal Article -
15
ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition
Published in Theranostics (01-01-2022)“…The mitogen-activated protein kinase pathway (MAPK) is one of the major cancer-driving pathways found in non-small cell lung cancer (NSCLC) patients. ERK…”
Get full text
Journal Article -
16
A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition
Published in Cancers (06-05-2022)“…Epithelial ovarian cancer is the most lethal malignancy of the female reproductive tract. A healthy ovary expresses both Estrogen Receptor α (ERα) and β (ERβ)…”
Get full text
Journal Article -
17
Abstract 889: NF-κB-mediated mitophagy contributes to the maintenance of cancer stem cells in ovarian cancer
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Tumors contain phenotypically and functionally heterogeneous cancer cells. Among them, a minority of cell subpopulation, termed cancer stem cells…”
Get full text
Journal Article -
18
Abstract 1519: ALDH1A1 enhances micro homology-mediated end joining by increasing POLQ expression
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Aldehyde dehydrogenase (ALDH) is a superfamily of 19 known enzymes that participated in the metabolism of endogenous and exogenous aldehydes. ALDH1A1…”
Get full text
Journal Article -
19
Abstract 3325: ERK inhibitor increases cancer stem cell population in NSCLC through Slug-Mediated epithelial-to-mesenchymal transition
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract The aberrant activation of the Mitogen-activated protein kinase pathway (MAPK/ERK pathway) has been found to play an important role in many cancers…”
Get full text
Journal Article -
20
Abstract GMM-017: UPREGULATION OF MIR-328 CONTRIBUTES TO OVARIAN CANCER STEM CELL MAINTENANCE BY DOWNREGULATING DDB2
Published in Clinical cancer research (15-11-2019)“…Abstract Cancer stem cells (CSCs) are a particular subpopulation of cells that are characterized by self renewal, differentiation and enhanced tumorigenicity…”
Get full text
Journal Article