Search Results - "Cai, Mengyin"

The many faces of diabetes: a disease with increasing heterogeneity by Tuomi, Tiinamaija, MD, Santoro, Nicola, MD, Caprio, Sonia, Prof, Cai, Mengyin, MD, Weng, Jianping, Prof, Groop, Leif, Prof

“…Summary Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent…”
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Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney by De Marinis, Yang, Cai, Mengyin, Bompada, Pradeep, Atac, David, Kotova, Olga, Johansson, Martin E, Garcia-Vaz, Eliana, Gomez, Maria F, Laakso, Markku, Groop, Leif

“…Diabetic kidney disease is the leading cause of end-stage renal disease. Genetic factors have been suggested to contribute to its susceptibility. However,…”
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Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney by Cai, Mengyin, Bompada, Pradeep, Atac, David, Laakso, Markku, Groop, Leif, De Marinis, Yang

“…Diabetes nephropathy (DN) is the leading cause of end stage renal disease and it affects up to 40% of diabetic patients. In addition to hyperglycemia, genetic…”
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Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD by Cao, Huanyi, Cai, Qingxian, Guo, Wanrong, Su, Qiao, Qin, Hancheng, Wang, Tian, Xian, Yingxin, Zeng, Longyi, Cai, Mengyin, Guan, Haixia, Chen, Sifan, Liang, Hua, Xu, Fen

“…Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of…”
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Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis by Guo, Wanrong, Cao, Huanyi, Shen, Yunfeng, Li, Wuguo, Wang, Wei, Cheng, Lidan, Cai, Mengyin, Xu, Fen

“…Background The effectiveness of ketogenic diet (KD) in ameliorating fatty liver has been established, although its mechanism is under investigation. Fibroblast…”
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Exenatide inhibits the growth of endometrial cancer Ishikawa xenografts in nude mice by ZHANG, YU, XU, FEN, LIANG, HUA, CAI, MENGYIN, WEN, XINQIAO, LI, XIAOMAO, WENG, JIANPING

“…Studies have showed that diabetes is one of the high risk factors of endometrial cancer; however, no reports describe the anti- or pro-cancer effect of a new…”
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The SRE Motif in the Human PNPLA3 Promoter (−97 to −88 bp) Mediates Transactivational Effects of SREBP-1c by Liang, Hua, Xu, Jing, Xu, Fen, Liu, Hongxia, Yuan, Ding, Yuan, Shuhua, Cai, Mengyin, Yan, Jinhua, Weng, Jianping

“…Patatin‐like phospholipase domain containing 3 (PNPLA3) is a non‐secreted protein primarily expressed in liver and adipose tissue. Recently, numerous genetic…”
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Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription by Bi, Yan, Wu, Wenjun, Shi, Junfeng, Liang, Hua, Yin, Wenwen, Chen, Yingying, Tang, Sunyinyan, Cao, Shu, Cai, Mengyin, Shen, Shanmei, Gao, Qian, Weng, Jianping, Zhu, Dalong

“…Aims/hypothesis Sterol regulatory element binding protein-1c (SREBP-1c) is a master regulator of fatty acid synthase and controls lipogenesis. IRS-1 is the key…”
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Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis by Liang, Riying, Wang, Meijun, Fu, Chang, Liang, Hua, Deng, Hongrong, Tan, Ying, Xu, Fen, Cai, Mengyin

“…Background: Obesity is associated with the development and progression of chronic kidney disease. Emerging evidence suggests that glucagon-like peptide-1…”
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Insight into the biochemical characteristics of a novel glucokinase gene mutation by Shen, Yunfeng, Cai, Mengyin, Liang, Hua, Wang, Hongwei, Weng, Jianping

“…Glucokinase (GCK) acts as a glucose sensor and regulates β-cell insulin secretion. The heterozygous mutations in the gene encoding GCK cause a reduction of the…”
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Diabetes causes multiple genetic alterations and downregulates expression of DNA repair genes in the prostate by Ye, Chunwei, Li, Xiaojuan, Wang, Yu, Zhang, Yuying, Cai, Mengyin, Zhu, Baoyi, Mu, Panwei, Xia, Xuan, Zhao, Yi, Weng, Jianping, Gao, Xin, Wen, Xingqiao

“…The molecular impact of diabetes mellitus on prostate gland has not been elucidated. In this study, we performed a whole-genome cDNA microarray analysis using…”
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6q24 transient neonatal diabetes mellitus： the first case report from China by Yao, Bin, Zhang, Xinhan, Liang, Hua, Xu, Wen, Cai, Mengyin, Yan, Jinhua, Weng, Jianping

“…To the editor： Neonatal diabetes mellitus （NDM） is one kind of monogenic diabetes which usually presents within 6 months after birth and needs insulin…”
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Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element–binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat–diet and streptozotocin-induced diabetic rats by Bi, Yan, Cai, Mengyin, Liang, Hua, Sun, Weiping, Li, Xiubin, Wang, Chunxia, Zhu, Yanhua, Chen, Xiang, Li, Ming, Weng, Jianping

“…Abstract We previously reported that early insulin treatment reduced intramuscular triglyceride content in type 2 diabetes mellitus Sprague-Dawley rats; the…”
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SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress by Zheng, Xiaobin, Xu, Fen, Liang, Hua, Cao, Huanyi, Cai, Mengyin, Xu, Wen, Weng, Jianping

“…Recent studies have indicated that lipid‐induced endoplasmic reticulum (ER) stress is a major contributor to the progression of hepatic steatosis. Exenatide…”
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SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis by Shen, Yunfeng, Cheng, Lidan, Xu, Minxuan, Wang, Wei, Wan, Zhiping, Xiong, Haixia, Guo, Wanrong, Cai, Mengyin, Xu, Fen

“…Activation of hepatic stellate cells (HSCs), the central event of fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs…”
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1572-P: Lipotoxicity-Induced TET1 Mediates CD36 DNA Demethylation in Liver Macrophages to Aggravate NAFLD Progression by Yu, Piaojian, Xian, Yingxin, Cao, Huanyi, Deng, Xiaojie, Cai, Mengyin, Xu, Fen

“…Aims: DNA methylation is dysregulated in nonalcoholic fatty liver disease (NAFLD), yet the dominant genes and regulatory mechanisms remain obscure. Here,…”
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394-P: Empagliflozin Ameliorate Renal Fibrosis in DKD by Cai, Xiang, Cao, Huanyi, Wang, Meijun, Yu, Piaojian, Liang, Xiaoqi, Liang, Hua, Xu, Fen, Cai, Mengyin

“…Introduction & Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve renal outcomes in diabetic kidney disease (DKD), but the mechanisms…”
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1784-LB: LRP5 Promotes Fatty Acid Oxidation through Enhancement of PPAR/PGC-1 Signaling in DKD with Dyslipidemia by He, Xuemin, Zhang, Rui, Wen, Siying, Xiang, Xiaoxin, Cai, Mengyin, Chen, Yanming

“…Dyslipidemia is an independent risk factor for diabetic kidney disease (DKD), but some lipid-lowering drugs are reported to exacerbate this disease, as they…”
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520-P: Exenatide Ameliorates Diabetic Kidney Disease by Inhibiting Apoptosis via SIRT1/TXNIP Signal Pathway by WANG, MEIJUN, LIANG, RIYING, XU, FEN, CAI, MENGYIN

“…Recent studies have indicated apoptosis to be a major contributor to the progression of Diabetic Kidney Disease. GLP-1 agonist such as Exenatide, which…”
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1138-P: Empagliflozin Ameliorates Kidney Injury in Diabetic Nephropathy via SIRT1 and TXNIP by LIANG, RIYING, WANG, MEIJUN, XU, FEN, CAI, MENGYIN

“…SGLT2 inhibitor empagliflozin can slower the decline of eGFR and reduce the occurrence rate of end-stage kidney disease according to EMPA-REG OUTCOME Clinical…”
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