Search Results - "Cai, Lisi"

Weigh the pros and cons to ovarian reserve before stripping ovarian endometriomas prior to IVF/ICSI: A meta-analysis by Tao, Xin, Chen, Lei, Ge, Shuqi, Cai, Lisi

“…To explore the effects of conservative surgery for endometriomas on ovarian responsiveness during assisted reproductive technology (ART) and provide…”
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Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase by Huang, Wei-Sheng, Liu, Shuangying, Zou, Dong, Thomas, Mathew, Wang, Yihan, Zhou, Tianjun, Romero, Jan, Kohlmann, Anna, Li, Feng, Qi, Jiwei, Cai, Lisi, Dwight, Timothy A, Xu, Yongjin, Xu, Rongsong, Dodd, Rory, Toms, Angela, Parillon, Lois, Lu, Xiaohui, Anjum, Rana, Zhang, Sen, Wang, Frank, Keats, Jeffrey, Wardwell, Scott D, Ning, Yaoyu, Xu, Qihong, Moran, Lauren E, Mohemmad, Qurish K, Jang, Hyun Gyung, Clackson, Tim, Narasimhan, Narayana I, Rivera, Victor M, Zhu, Xiaotian, Dalgarno, David, Shakespeare, William C

“…In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC),…”
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Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats by Tao, Xin, Cai, Lisi, Chen, Lei, Ge, Shuqi, Deng, Xuanying

“…This study was designed to evaluate the protective effects of AMPKα and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying mechanisms…”
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Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant by Huang, Wei-Sheng, Metcalf, Chester A, Sundaramoorthi, Raji, Wang, Yihan, Zou, Dong, Thomas, R. Mathew, Zhu, Xiaotian, Cai, Lisi, Wen, David, Liu, Shuangying, Romero, Jan, Qi, Jiwei, Chen, Ingrid, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Zhou, Tianjun, Commodore, Lois, Narasimhan, Narayana I, Mohemmad, Qurish K, Iuliucci, John, Rivera, Victor M, Dalgarno, David C, Sawyer, Tomi K, Clackson, Tim, Shakespeare, William C

“…In the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors, the T315I gatekeeper mutant has emerged as resistant to all currently…”
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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant by Thomas, Mathew, Huang, Wei-Sheng, Wen, David, Zhu, Xiaotian, Wang, Yihan, Metcalf, Chester A., Liu, Shuangying, Chen, Ingrid, Romero, Jan, Zou, Dong, Sundaramoorthi, Raji, Li, Feng, Qi, Jiwei, Cai, Lisi, Zhou, Tianjun, Commodore, Lois, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T., Broudy, Marc I., Russian, Karin, Iuliucci, John, Rivera, Victor M., Sawyer, Tomi K., Dalgarno, David C., Clackson, Tim, Shakespeare, William C.

“…We describe the design, synthesis and structure–activity relationship studies for a series of hetero-monocyclic ponatinib analogues as potent inhibitors of…”
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A Model Study toward the Total Synthesis of N-Deacetyllappaconitine by Taber, Douglass F, Liang, Jiang-Lin, Chen, Bei, Cai, Lisi

“…A model study leading to the preparation of the AEF rings of N-deacetyllappaconitine is described. The conjugate addition to the α-alkyl cyclohexenone 10…”
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Preparation of Ketones from Nitriles and Phosphoranes by Taber, Douglass F, Cai, Lisi

“…The preparation of a ketone from a phosphorane and a nitrile is described. The workup conditions are mild, and the yields are high. The unreacted starting…”
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Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study by Tao, Xin, Chen, Lei, Cai, Lisi, Ge, Shuqi, Deng, Xuanying

“…In order to preliminarily explore the correlation between the AMPKα-SIRT1 pathway and insulin resistance and reproductive function in PCOS mice and find the…”
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Effects of metformin and Exenatide on insulin resistance and AMPK[alpha]-SIRT1 molecular pathway in PCOS rats by Tao, Xin, Cai, Lisi, Chen, Lei, Ge, Shuqi, Deng, Xuanying

“…Aims This study was designed to evaluate the protective effects of AMPK[alpha] and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying…”
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Abstract 2827: Discovery of AP26113, a potent, orally active inhibitor of anaplastic lymphoma kinase and clinically relevant mutants by Huang, Wei-Sheng, Li, Feng, Cai, Lisi, Xu, Yongjin, Zhang, Sen, Wardwell, Scott D., Ning, Yaoyu, Kohlmann, Anna, Zhou, Tianjun, Ye, Emily Y., Zhu, Xiaotian, Narasimhan, Narayana I., Clackson, Tim, Rivera, Victor M., Dalgarno, David, Shakespeare, William C.

“…Abstract Phosphorus, despite its abundance in the human body, is rarely found in drug molecules, with clinical utility limited to a few phosphonic or…”
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Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I by Shakespeare, William C., Wang, Frank, Xu, Qihong, Zhu, Xiaotian, Narasimham, Narayana, Metcalf, Chester A., Wang, Yihan, Sundaramoorthi, Raji, Huang, Wei-Sheng, Zou, Dong, Thomas, Mathew, Romero, Jan, Wen, David, Chen, Ingrid, Cai, Lisi, Liu, Shuangying, Wardwell, Scott, Ning, Yaoyu, Keats, Jeff, Snodgrass, Joseph, Russian, Karin, Broudy, Marc, O'Hare, Thomas, Smith, Caitlyn, Corbin, Amie, Druker, Brian, Iuliucci, John, Dalgarno, David, Sawyer, Tomi K., Clackson, Tim

“…Resistance to the Bcr-Abl kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML) is associated with emergence of Bcr-Abl point mutations…”
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