Search Results - "Cai, Jingli"

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD by Westergard, Thomas, Jensen, Brigid K., Wen, Xinmei, Cai, Jingli, Kropf, Elizabeth, Iacovitti, Lorraine, Pasinelli, Piera, Trotti, Davide

“…Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain by Lin, Ruihe, Cai, Jingli, Kenyon, Lawrence, Iozzo, Renato, Rosenwasser, Robert, Iacovitti, Lorraine

“…It is well documented that adult neural stem cells (NSCs) residing in the subventricular zone (SVZ) and the subgranular zone (SGZ) are induced to proliferate…”
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Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability by Lin, Ruihe, Cai, Jingli, Nathan, Cody, Wei, Xiaotao, Schleidt, Stephanie, Rosenwasser, Robert, Iacovitti, Lorraine

“…Abstract Previous studies have established the subventricular (SVZ) and subgranular (SGZ) zones as sites of neurogenesis in the adult forebrain ( Doetsch et…”
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Inhibition of CD133 Overcomes Cisplatin Resistance Through Inhibiting PI3K/AKT/mTOR Signaling Pathway and Autophagy in CD133-Positive Gastric Cancer Cells by Lu, Ruiqi, Zhao, Gang, Yang, Yulong, Jiang, Zhaoyan, Cai, Jingli, Hu, Hai

“…Cisplatin is widely used as the standard gastric cancer treatment, but the relapse and metastasis are common as intrinsic or acquired drug resistance. CD133…”
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Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease by Kostuk, Eric Wildon, Cai, Jingli, Iacovitti, Lorraine

“…Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring…”
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METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10 by Cai, Jingli, Cui, Zheng, Zhou, Jingyi, Zhang, Bosen, Lu, Ruiqi, Ding, Youcheng, Hu, Hai

“…N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of…”
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N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data by Monti, Daniel A, Zabrecky, George, Kremens, Daniel, Liang, Tsao-Wei, Wintering, Nancy A, Cai, Jingli, Wei, Xiatao, Bazzan, Anthony J, Zhong, Li, Bowen, Brendan, Intenzo, Charles M, Iacovitti, Lorraine, Newberg, Andrew B

“…The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD). The overarching goal of…”
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Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation by Petruk, Svetlana, Cai, Jingli, Sussman, Robyn, Sun, Guizhi, Kovermann, Sina K., Mariani, Samanta A., Calabretta, Bruno, McMahon, Steven B., Brock, Hugh W., Iacovitti, Lorraine, Mazo, Alexander

“…Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation…”
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Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats by Cai, Jingli, Yang, Ming, Poremsky, Elizabeth, Kidd, Sarah, Schneider, Jay S, Iacovitti, Lorraine

“…Cell replacement therapy could be an important treatment strategy for Parkinson's disease (PD), which is caused by the degeneration of dopamine neurons in the…”
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Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer’s Disease Model by Fu, Chia-Hsuan, Iascone, Daniel Maxim, Petrof, Iraklis, Hazra, Anupam, Zhang, Xiaohong, Pyfer, Mark S., Tosi, Umberto, Corbett, Brian F., Cai, Jingli, Lee, Jason, Park, Jin, Iacovitti, Lorraine, Scharfman, Helen E., Enikolopov, Grigori, Chin, Jeannie

“…Adult hippocampal neurogenesis has been reported to be decreased, increased, or not changed in Alzheimer’s disease (AD) patients and related transgenic mouse…”
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IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization by Qin, Jian, Cui, Zheng, Zhou, Jingyi, Zhang, Bosen, Lu, Ruiqi, Ding, Youcheng, Hu, Hai, Cai, Jingli

“…•IGF2BP3 overexpression promote gallbladder cancer growth and indicate poor prognosis.•IGF2BP3 activates NF-kB pathway by upregulating CLDN4 to promote…”
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Free fatty acids and triglyceride change in the gallbladder bile of gallstone patients with pancreaticobiliary reflux by Xiang, Yukai, Kong, Xiangyu, Zhang, Cheng, He, Chuanqi, Cai, Jingli, Lu, Ruiqi, Zhang, Bosen, Lu, Liu, Yang, Yulong

“…Pancreaticobiliary reflux (PBR) causes chronic inflammation of the gallbladder mucosa and changes in the bile components, which are known to promote gallstone…”
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A stress-free strategy to correct point mutations in patient iPS cells by Cai, Jingli, Kropf, Elizabeth, Hou, Ya-Ming, Iacovitti, Lorraine

“…•A CRISPR-Cas9 gene knock-in method for correction of point mutations or frameshifting.•sgRNA sequences selected from the nearest intron of the mutation…”
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Identification of changes in bile composition in pancreaticobiliary reflux based on liquid chromatography/mass spectrometry metabolomics by Da, Xuanbo, Xiang, Yukai, Hu, Hai, Kong, Xiangyu, Qiu, Chen, Jiang, Zhaoyan, Zhao, Gang, Cai, Jingli, Huang, Anhua, Zhang, Cheng, He, Chuanqi, Lv, Beining, Zhang, Honglei, Yang, Yulong

“…Pancreaticobiliary reflux (PBR) can induce gallstone formation; however, its pathogenic mechanism remains unclear. In this study, we explored the mechanism of…”
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Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification by Petruk, Svetlana, Mariani, Samanta A., De Dominici, Marco, Porazzi, Patrizia, Minieri, Valentina, Cai, Jingli, Iacovitti, Lorraine, Flomenberg, Neal, Calabretta, Bruno, Mazo, Alexander

“…The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs…”
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Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons by Phani, Sudarshan, Jablonski, Michael, Pelta-Heller, Josh, Cai, Jingli, Iacovitti, Lorraine

“…Abstract Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons…”
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Dopaminergic Differentiation of Human Embryonic Stem Cells by Zeng, Xianmin, Cai, Jingli, Chen, Jia, Luo, Yongquan, You, Zhi‐Bing, Fotter, Erin, Wang, Yun, Harvey, Brandon, Miura, Takumi, Backman, Cristina, Chen, Guann‐Juh, Rao, Mahendra S., Freed, William J.

“…In this manuscript we report that human embryonic stem cells (hESCs) differentiated into dopaminergic neurons when cocultured with PA6 cells. After 3 weeks of…”
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The hTH-GFP reporter rat model for the study of Parkinson's disease by Iacovitti, Lorraine, Wei, Xiaotao, Cai, Jingli, Kostuk, Eric W, Lin, Ruihe, Gorodinsky, Alexander, Roman, Philip, Kusek, Gretchen, Das, Sonal S, Dufour, Audrey, Martinez, Terina N, Dave, Kuldip D

“…Parkinson disease (PD) is the second leading neurodegenerative disease in the US. As there is no known cause or cure for PD, researchers continue to…”
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Assessing Self‐Renewal and Differentiation in Human Embryonic Stem Cell Lines by Cai, Jingli, Chen, Jia, Liu, Ying, Miura, Takumi, Luo, Yongquan, Loring, Jeanne F., Freed, William J., Rao, Mahendra S., Zeng, Xianmin

“…Like other cell populations, undifferentiated human embryonic stem cells (hESCs) express a characteristic set of proteins and mRNA that is unique to the cells…”
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MicroRNA-146b-5p inhibits the growth of gallbladder carcinoma by targeting epidermal growth factor receptor by CAI, JINGLI, XU, LUBAI, CAI, ZHENZHAI, WANG, JISHENG, ZHOU, BING, HU, HAI

“…Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. The study of potential treatments for GBC has recently focused on…”
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