Search Results - "Cai, Houjian"

Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery by Zhang, Weizhong, Wang, Mengzhe, Tang, Wei, Wen, Ru, Zhou, Shiyi, Lee, Chaebin, Wang, Hui, Jiang, Wen, Delahunty, Ian Michael, Zhen, Zipeng, Chen, Hongmin, Chapman, Matthew, Wu, Zhanhong, Howerth, Elizabeth W., Cai, Houjian, Li, Zibo, Xie, Jin

“…Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a…”
Get full text

Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing by Whitley, Joseph Andrew, Cai, Houjian

“…Abstract Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with tremendous therapeutic potential. Recently, ribonucleoprotein…”
Get full text

Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression by Kim, Sungjin, Alsaidan, Omar Awad, Goodwin, Octavia, Li, Qianjin, Sulejmani, Essilvo, Han, Zhen, Bai, Aiping, Albers, Thomas, Beharry, Zanna, Zheng, Y George, Norris, James S, Szulc, Zdzislaw M, Bielawska, Alicja, Lebedyeva, Iryna, Pegan, Scott D, Cai, Houjian

“…Protein -myristoylation enables localization to membranes and helps maintain protein conformation and function. -myristoyltransferases (NMT) catalyze co- or…”
Get full text

Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation by Ma, Yongjie, Zha, Junyi, Yang, XiangKun, Li, Qianjin, Zhang, Qingfu, Yin, Amelia, Beharry, Zanna, Huang, Hanwen, Huang, Jiaoti, Bartlett, Michael, Ye, Kaixiong, Yin, Hang, Cai, Houjian

“…Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Long-chain fatty…”
Get full text

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth by Mulholland, David J., Tran, Linh M., Li, Yunfeng, Cai, Houjian, Morim, Ashkan, Wang, Shunyou, Plaisier, Seema, Garraway, Isla P., Huang, Jiaoti, Graeber, Thomas G., Wu, Hong

“…Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC…”
Get full text

Myristoylation of Src kinase mediates Src-induced and high-fat diet–accelerated prostate tumor progression in mice by Kim, Sungjin, Yang, Xiangkun, Li, Qianjin, Wu, Meng, Costyn, Leah, Beharry, Zanna, Bartlett, Michael G., Cai, Houjian

“…Exogenous fatty acids provide substrates for energy production and biogenesis of the cytoplasmic membrane, but they also enhance cellular signaling during…”
Get full text

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma by Kummetha Venkata, Jagadish, An, Ningfei, Stuart, Robert, Costa, Luciano J., Cai, Houjian, Coker, Woodrow, Song, Jin H., Gibbs, Kiwana, Matson, Terri, Garrett-Mayer, Elizabeth, Wan, Zhuang, Ogretmen, Besim, Smith, Charles, Kang, Yubin

“…Sphingolipid metabolism is being increasingly recognized as a key pathway in regulating cancer cell survival and proliferation. However, very little is known…”
Get full text

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression by Drake, Justin M, Graham, Nicholas A, Stoyanova, Tanya, Sedghi, Amir, Goldstein, Andrew S, Cai, Houjian, Smith, Daniel A, Zhang, Hong, Komisopoulou, Evangelia, Huang, Jiaoti, Graeber, Thomas G, Witte, Owen N

“…Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer. We demonstrate that…”
Get full text

Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy by HOUJIAN CAI, BABIC, Ivan, XIAO WEI, JIAOTI HUANG, WITTE, Owen N

“…Cellular Src (c-Src) integrates a large number of signal transduction pathways regulating cell division, migration, and other aspects of cell physiology…”
Get full text

Paracrine Fibroblast Growth Factor Initiates Oncogenic Synergy with Epithelial FGFR/Src Transformation in Prostate Tumor Progression by Li, Qianjin, Ingram, Lishann, Kim, Sungjin, Beharry, Zanna, Cooper, Jonathan A., Cai, Houjian

“…Cross talk of stromal-epithelial cells plays an essential role in both normal development and tumor initiation and progression. Fibroblast growth factor…”
Get full text

Differential transformation capacity of Src family kinases during the initiation of prostate cancer by Cai, Houjian, Smith, Daniel A, Memarzadeh, Sanaz, Lowell, Clifford A, Cooper, Jonathan A, Witte, Owen N

“…Src family kinases (SFKs) are pleiotropic activators that are responsible for integrating signal transduction for multiple receptors that regulate cellular…”
Get full text

Encapsulating Cas9 into extracellular vesicles by protein myristoylation by Whitley, Joseph Andrew, Kim, Sungjin, Lou, Lei, Ye, Chenming, Alsaidan, Omar Awad, Sulejmani, Essilvo, Cai, Jingwen, Desrochers, Ellison Gerona, Beharry, Zanna, Rickman, Catherine Bowes, Klingeborn, Mikael, Liu, Yutao, Xie, Zhong‐Ru, Cai, Houjian

“…CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate…”
Get full text

Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells by Li, Qianjin, Alsaidan, Omar A., Rai, Sumit, Wu, Meng, Shen, Huifeng, Beharry, Zanna, Almada, Luciana L., Fernandez-Zapico, Martin E., Wang, Lianchun, Cai, Houjian

“…Interactions between cells in the stroma and epithelium facilitate prostate stem cell activity and tissue regeneration capacity. Numerous molecular signal…”
Get full text

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis by Wu, Meng, Ingram, Lishann, Tolosa, Ezequiel J., Vera, Renzo E., Li, Qianjin, Kim, Sungjin, Ma, Yongjie, Spyropoulos, Demetri D., Beharry, Zanna, Huang, Jiaoti, Fernandez-Zapico, Martin E., Cai, Houjian

“…Although the differentiation of oncogenically transformed basal progenitor cells is one of the key steps in prostate tumorigenesis, the mechanisms mediating…”
Get full text

Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer by HOUJIAN CAI, MEMARZADEH, Sanaz, STOYANOVA, Tanya, BEHARRY, Zanna, KRAFT, Andrew S, WITTE, Owen N

“…Elevation of the chromatin repression factor enhancer of zeste homolog (EZH2) is associated with progression and poor prognosis in several human cancers…”
Get full text

Src family kinases engage differential pathways for encapsulation into extracellular vesicles by Ye, Chenming, Gosser, Cade, Runyon, Ethan Daniel, Zha, Junyi, Cai, Jingwen, Beharry, Zanna, Bowes Rickman, Catherine, Klingeborn, Mikael, Liu, Yutao, Xie, Jin, Cai, Houjian

“…Extracellular vesicles (EVs) are heterogeneous biological nanoparticles secreted by all cell types. Identifying the proteins preferentially encapsulated in…”
Get full text

Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal by Memarzadeh, Sanaz, Cai, Houjian, Janzen, Deanna M, Xin, Li, Lukacs, Rita, Riedinger, Mireille, Zong, Yang, DeGendt, Karel, Verhoeven, Guido, Huang, Jiaoti, Witte, Owen N

“…The steroid hormone signaling axis is thought to play a central role in initiation and progression of many hormonally regulated epithelial tumors. It is…”
Get full text

Differential Regulation and Substrate Preferences in Two Peptide Transporters of Saccharomyces cerevisiae by Cai, Houjian, Hauser, Melinda, Naider, Fred, Becker, Jeffrey M

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Nutrient regulation of oligopeptide transport in Saccharomyces cerevisiae by Wiles, Amy M, Cai, Houjian, Naider, Fred, Becker, Jeffrey M

“…1 Department of Biochemistry, Cell and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA 2 Department of Microbiology, University of…”
Get full text

Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes by Verweij, Frederik J., de Heus, Cecilia, Kroeze, Stefanie, Cai, Houjian, Kieff, Elliott, Piersma, Sander R., Jimenez, Connie R., Middeldorp, Jaap M., Pegtel, Dirk Michiel

“…The Epstein-Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP1) constitutively activates nuclear factor κB (NFκB) from intracellular…”
Get full text