Search Results - "Cai, Guoxiang"
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Predicting distant metastasis and chemotherapy benefit in locally advanced rectal cancer
Published in Nature communications (27-08-2020)“…Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control…”
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Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer
Published in Journal of experimental & clinical cancer research (10-01-2019)“…Emerging evidence suggests a potential relationship between gut microbiota and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu)…”
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Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
Published in Nature communications (05-03-2020)“…Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the…”
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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Published in The ISME Journal (01-02-2012)“…Despite a long-suspected role in the development of human colorectal cancer (CRC), the composition of gut microbiota in CRC patients has not been adequately…”
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Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer
Published in Molecular cancer (24-08-2016)“…Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in…”
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MALAT1 regulates the transcriptional and translational levels of proto-oncogene RUNX2 in colorectal cancer metastasis
Published in Cell death & disease (16-05-2019)“…Ectopic expression of lncRNA-MALAT1 has been discovered in recurrent colorectal cancer (CRC) and metastatic sites in postsurgical patients, however, its…”
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A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer
Published in Journal of translational medicine (30-01-2020)“…Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic…”
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Development of a novel combined nomogram model integrating deep learning-pathomics, radiomics and immunoscore to predict postoperative outcome of colorectal cancer lung metastasis patients
Published in Journal of hematology and oncology (24-01-2022)“…Limited previous studies focused on the death and progression risk stratification of colorectal cancer (CRC) lung metastasis patients. The aim of this study is…”
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MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2
Published in Oncotarget (09-08-2016)“…microRNA-27a (miR-27a) is frequently dysregulated in human carcinoma, including gastric cancer. The B-cell translocation gene 2 (BTG2) has been implicated in…”
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The Critical Role of Tumor Size in Predicting Prognosis for T1 Colon Cancer
Published in The oncologist (Dayton, Ohio) (01-03-2020)“…Background The role of horizontal growth index of tumor size in survival prediction is still underappreciated in colon cancer because of the identification of…”
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Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer
Published in Cell death & disease (28-02-2020)“…Long noncoding RNAs (lncRNAs) have been revealed to play critical roles in tumor initiation and progression. The antisense lncRNA LDLRAD4-AS1 is the longest…”
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A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential
Published in Clinical cancer research (15-04-2014)“…Metabolic phenotyping has provided important biomarker findings, which, unfortunately, are rarely replicated across different sample sets due to the variations…”
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Nomogram to predict the risk and survival of synchronous bone metastasis in colorectal cancer: a population-based real-world analysis
Published in International journal of colorectal disease (01-08-2020)“…Purpose Bone metastasis (BM) can obviously affect the quality of life of patients in colorectal cancer (CRC), and the whole management of patients with BM…”
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Serum Metabolite Profiling of Human Colorectal Cancer Using GC−TOFMS and UPLC−QTOFMS
Published in Journal of proteome research (01-10-2009)“…Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly…”
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The safety and effectiveness of carbon nanoparticles suspension in tracking lymph node metastases of colorectal cancer: a prospective randomized controlled trial
Published in Japanese journal of clinical oncology (05-05-2020)“…This study was to evaluate the safety and effectiveness of carbon nanoparticles suspension in tracking lymph node metastases of colorectal cancer. Eligible…”
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Better long-term survival in young patients with non-metastatic colorectal cancer after surgery, an analysis of 69,835 patients in SEER database
Published in PloS one (01-04-2014)“…To compare the long-term survival of colorectal cancer (CRC) in young patients with elderly ones. Using Surveillance, Epidemiology, and End Results (SEER)…”
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Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study
Published in EBioMedicine (01-07-2021)“…Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in…”
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GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
Published in Signal transduction and targeted therapy (02-09-2020)“…Cancer cells are usually characterized by hyperactive glucose metabolism, which can often lead to glucose scarcity; thus, alternative pathways to rewire cancer…”
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A robust gene signature for the prediction of early relapse in stage I–III colon cancer
Published in Molecular oncology (01-04-2018)“…Colon cancer patients experiencing early relapse consistently exhibited poor survival. The aim of our study was to develop an mRNA signature that can help to…”
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Development and Validation of an Autophagy Score Signature for the Prediction of Post-operative Survival in Colorectal Cancer
Published in Frontiers in oncology (09-09-2019)“…Background: Survival rates for Colorectal cancer (CRC) patients who experienced early relapse have usually been relatively low. Our study aims at developing an…”
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