Search Results - "Cahill, Sean M."

A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral…”
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A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice by Malonis, Ryan J, Georgiev, George I, Haslwanter, Denise, VanBlargan, Laura A, Fallon, Georgia, Vergnolle, Olivia, Cahill, Sean M, Harris, Richard, Cowburn, David, Chandran, Kartik, Diamond, Michael S, Lai, Jonathan R

“…Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or…”
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Self-Reporting Fluorescent Substrates of Protein Tyrosine Kinases by Wang, Qunzhao, Cahill, Sean M, Blumenstein, Michael, Lawrence, David S

“…A new mechanistic principle by which protein tyrosine kinase substrates fluorescently report the introduction of a phosphate moiety has been developed. NMR was…”
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Light-Regulated Sampling of Protein Tyrosine Kinase Activity by Wang, Qunzhao, Dai, Zhaohua, Cahill, Sean M, Blumenstein, Michael, Lawrence, David S

“…Protein tyrosine kinases serve as key mediators of signaling pathways, biochemical highways that control various aspects of cell behavior. Although fluorescent…”
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Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit by Shekar, S. Chandra, Wu, Haiyan, Fu, Zheng, Yip, Shu-Chin, Nagajyothi, Cahill, Sean M., Girvin, Mark E., Backer, Jonathan M.

“…p85/p110 phosphoinositide 3-kinases regulate multiple cell functions and are frequently mutated in human cancer. The p85 regulatory subunit stabilizes and…”
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Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A by Niland, Courtney N, Ghosh, Agnidipta, Cahill, Sean M, Schramm, Vern L

“…S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. Its contribution…”
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Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution by Ghosh, Agnidipta, Niland, Courtney N, Cahill, Sean M, Karadkhelkar, Nishant M, Schramm, Vern L

“…Human methionine adenosyltransferase MAT2A provides S-adenosyl-l-methionine (AdoMet) for methyl-transfer reactions. Epigenetic methylations influence…”
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Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State by Paparella, Ashleigh S., Cahill, Sean M., Aboulache, Briana L., Schramm, Vern L.

“…Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal…”
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Insights into the Interaction Landscape of the EVH1 Domain of Mena by LaComb, Lanette, Ghosh, Agnidipta, Bonanno, Jeffrey B., Nilson, Daniel J., Poppel, Alex J., Dada, Lucas, Cahill, Sean M., Maianti, Juan Pablo, Kitamura, Seiya, Cowburn, David, Almo, Steven C.

“…The Enabled/VASP homology 1 (EVH1) domain is a small module that interacts with proline-rich stretches in its ligands and is found in various signaling and…”
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Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S N i Mechanism and Ion Pair Transition State by Paparella, Ashleigh S, Cahill, Sean M, Aboulache, Briana L, Schramm, Vern L

“…Toxins TcdA and TcdB from glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell rounding…”
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Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo by Georgiev, George I, Malonis, Ryan J, Wirchnianski, Ariel S, Wessel, Alex W, Jung, Helen S, Cahill, Sean M, Nyakatura, Elisabeth K, Vergnolle, Olivia, Dowd, Kimberly A, Cowburn, David, Pierson, Theodore C, Diamond, Michael S, Lai, Jonathan R

“…Zika virus (ZIKV) is a flavivirus that can cause severe disease, but there are no approved treatments or vaccines. A complication for flavivirus vaccine…”
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Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex by Upla, Paula, Kim, Seung Joong, Sampathkumar, Parthasarathy, Dutta, Kaushik, Cahill, Sean M., Chemmama, Ilan E., Williams, Rosemary, Bonanno, Jeffrey B., Rice, William J., Stokes, David L., Cowburn, David, Almo, Steven C., Sali, Andrej, Rout, Michael P., Fernandez-Martinez, Javier

“…The membrane ring that equatorially circumscribes the nuclear pore complex (NPC) in the perinuclear lumen of the nuclear envelope is composed largely of Pom152…”
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A Mechanistic Design Principle for Protein Tyrosine Kinase Sensors:  Application to a Validated Cancer Target by Wakata, Aya, Cahill, Sean M, Blumenstein, Michael, Gunby, Rosalind H, Jockusch, Steffen, Marti, Angel A, Cimbro, Barbara, Gambacorti-Passerini, Carlo, Donella-Deana, Arianna, Pinna, Lorenzo A, Turro, Nicholas J, Lawrence, David S

“…A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein…”
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Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase by V. T. Minnow, Yacoba, Suthagar, Kajitha, Clinch, Keith, Ducati, Rodrigo G., Ghosh, Agnidipta, Buckler, Joshua N., Harijan, Rajesh K., Cahill, Sean M., Tyler, Peter C., Schramm, Vern L.

“…Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase (PfHGXPRT) is essential for purine salvage of hypoxanthine into parasite purine…”
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Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Solvent Isotope-Induced Equilibrium Perturbation for Isocitrate Lyase by Quartararo, Christine E, Hadi, Timin, Cahill, Sean M, Blanchard, John S

“…Isocitrate lyase (ICL) catalyzes the reversible retro-aldol cleavage of isocitrate to generate glyoxylate and succinate. ICL is the first enzyme of the…”
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Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Change history: In the HTML version of this Letter, Extended Data Fig. 4 incorrectly corresponded to Fig. 4 (the PDF version of the figure was correct). This…”
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In vivo proton MR spectroscopy of pancreatic neuroendocrine tumors in a multiple endocrine neoplasia type 1 conditional knockout mouse model by Cui, Min-Hui, Branch, Craig A., Cahill, Sean M., Quinn, Thomas J., Adem, Asha, Libutti, Steven K., Yuan, Ziqiang

“…Purpose MR spectroscopy (MRS) can improve diagnosis and follow treatment in cancer. However, no study has yet reported application of in vivo 1H‐MRS in…”
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Isotropic Bicelles Stabilize the Functional Form of a Small Multidrug-Resistance Pump for NMR Structural Studies by Poget, Sébastien F, Cahill, Sean M, Girvin, Mark E

“…Detergent micelles are commonly used as solubilization agents in biophysical and biochemical studies of membrane proteins, but they do not ideally reproduce…”
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Multiple Alignment of Membrane Proteins for Measuring Residual Dipolar Couplings Using Lanthanide Ions Bound to a Small Metal Chelator by Kamen, Douglas E, Cahill, Sean M, Girvin, Mark E

“…NMR structure determination of helical integral membrane proteins is one of the most challenging undertakings in modern structural biology. The solubilizing…”
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