Search Results - "Cahill, Michael E."
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Dendritic spine pathology in neuropsychiatric disorders
Published in Nature neuroscience (01-03-2011)“…Although symptoms and onsets of neuropsychiatric/neurodegenerative diseases may differ markedly, there is evidence that these diseases may share common…”
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Dopaminergic dynamics underlying sex-specific cocaine reward
Published in Nature communications (10-01-2017)“…Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent. We…”
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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
Published in PLoS biology (03-02-2022)“…Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders originate from a complex interplay between genetics and early life…”
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4
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
Published in Genome biology (22-04-2014)“…Increasing evidence supports a role for altered gene expression in mediating the lasting effects of cocaine on the brain, and recent work has demonstrated the…”
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Role of Tet1 and 5-hydroxymethylcytosine in cocaine action
Published in Nature neuroscience (01-04-2015)“…Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine…”
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Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling
Published in Neuron (Cambridge, Mass.) (03-02-2016)“…Dendritic spines are the sites of most excitatory synapses in the CNS, and opposing alterations in the synaptic structure of medium spiny neurons (MSNs) of the…”
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Estrogen receptor α drives pro-resilient transcription in mouse models of depression
Published in Nature communications (16-03-2018)“…Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional…”
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Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Published in Neuron (Cambridge, Mass.) (21-11-2007)“…Activity-dependent rapid structural and functional modifications of central excitatory synapses contribute to synapse maturation, experience-dependent…”
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Assessing protein distribution and dendritic spine morphology relationships using structured illumination microscopy in cultured neurons
Published in STAR protocols (15-03-2024)“…Dendritic spines are protrusions on dendrites forming the postsynaptic aspect of excitatory connections within the brain. Spine morphology is associated with…”
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Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Published in Nature neuroscience (01-06-2012)“…Repeated exposure to cocaine increases dendritic spine density on nucleus accumbens (NAc) neurons. Here the authors show that the small GTPase Rac1 is…”
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Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Published in Nature neuroscience (01-03-2015)“…Comprehensive analysis of epigenetic regulation demonstrates a series of complex, interacting chromatin mechanisms by which chronic exposure to opiates…”
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Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure
Published in Journal of neurochemistry (01-10-2018)“…The nucleus accumbens (NAc) is a critical brain reward region that mediates the rewarding effects of drugs of abuse, including those of morphine and other…”
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Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
Published in Proceedings of the National Academy of Sciences - PNAS (04-08-2009)“…Dendritic spine morphogenesis contributes to brain function, cognition, and behavior, and is altered in psychiatric disorders. Kalirin is a brain-specific…”
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14
WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine
Published in Proceedings of the National Academy of Sciences - PNAS (07-02-2017)“…Wiskott-Aldrich syndrome protein (WASP) family verprolin homologous protein 1 (WAVE1) regulates actin-related protein 2/3 (Arp2/3) complex-mediated actin…”
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Neonatal Intermittent Hypoxia Induces Lasting Sex-Specific Augmentation of Rat Microglial Cytokine Expression
Published in Frontiers in immunology (02-07-2019)“…Sleep disordered breathing (SDB) affects 3-5% of the pediatric population, including neonates who are highly susceptible due to an underdeveloped ventilatory…”
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Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function
Published in iScience (15-09-2023)“…The effects of repeated stress on cognitive impairment are thought to be mediated, at least in part, by reductions in the stability of dendritic spines in…”
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Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease
Published in Neurobiology of aging (01-07-2005)“…The microtubule-associated protein, tau, is a highly soluble molecule that is nonetheless capable of self-association into filamentous deposits characteristic…”
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Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo
Published in Journal of neurochemistry (01-05-2006)“…The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and…”
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Afadin Is Required for Maintenance of Dendritic Structure and Excitatory Tone
Published in The Journal of biological chemistry (19-10-2012)“…The dendritic field of a neuron, which is determined by both dendritic architecture and synaptic strength, defines the synaptic input of a cell. Once…”
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Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology
Published in Neurobiology of disease (01-02-2012)“…Abstract Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of…”
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