Search Results - "Cahill, M."

Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach by Cahill, Kelly M., Huo, Zhiguang, Tseng, George C., Logan, Ryan W., Seney, Marianne L.

“…Recent advances in large-scale gene expression profiling necessitate concurrent development of biostatistical approaches to reveal meaningful biological…”
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Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics by Trang, Tuan, Al-Hasani, Ream, Salvemini, Daniela, Salter, Michael W, Gutstein, Howard, Cahill, Catherine M

“…Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in…”
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Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment by Comer, Sandra D., Cahill, Catherine M.

“…•Illicit fentanyl is sold as an adulterant to heroin and other drugs. The extent to which fentanyl alone is sold or sought out by drug users is…”
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TNF-alpha and neuropathic pain--a review by Leung, Lawrence, Cahill, Catherine M

“…Tumor necrosis factor alpha (TNF-alpha) was discovered more than a century ago, and its known roles have extended from within the immune system to include a…”
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Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories by Arya, Sagar S., Rookes, James E., Cahill, David M., Lenka, Sangram K.

“…Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant specialized metabolites (PSM). While Taxol® and ginsenoside are two…”
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A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral…”
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Iron-Responsive-Like Elements and Neurodegenerative Ferroptosis by Rogers, Jack T, Cahill, Catherine M

“…A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive…”
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Uptake and cellular distribution, in four plant species, of fluorescently labeled mesoporous silica nanoparticles by Sun, Dequan, Hussain, Hashmath I., Yi, Zhifeng, Siegele, Rainer, Cresswell, Tom, Kong, Lingxue, Cahill, David M.

“…Key message We report the uptake of MSNs into the roots and their movement to the aerial parts of four plant species and their quantification using…”
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Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides by Chaudhary, Suman, Kanwar, Rupinder K, Sehgal, Alka, Cahill, David M, Barrow, Colin J, Sehgal, Rakesh, Kanwar, Jagat R

“…Over the years, extensive use of commercially available synthetic pesticides against phytophagous insects has led to their bioaccumulation in the environment…”
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A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice by Malonis, Ryan J, Georgiev, George I, Haslwanter, Denise, VanBlargan, Laura A, Fallon, Georgia, Vergnolle, Olivia, Cahill, Sean M, Harris, Richard, Cowburn, David, Chandran, Kartik, Diamond, Michael S, Lai, Jonathan R

“…Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or…”
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Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis by Ferrini, Francesco, Trang, Tuan, Mattioli, Theresa-Alexandra M, Laffray, Sophie, Del'Guidice, Thomas, Lorenzo, Louis-Etienne, Castonguay, Annie, Doyon, Nicolas, Zhang, Wenbo, Godin, Antoine G, Mohr, Daniela, Beggs, Simon, Vandal, Karen, Beaulieu, Jean-Martin, Cahill, Catherine M, Salter, Michael W, De Koninck, Yves

“…Treatment of pain with morphine leads to paradoxical hyperalgesia. The authors provide evidence that morphine-induced hyperalgesia is a result of…”
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Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence by Mattioli, Theresa Alexandra, Leduc-Pessah, Heather, Skelhorne-Gross, Graham, Nicol, Chris J B, Milne, Brian, Trang, Tuan, Cahill, Catherine M

“…The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the…”
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Microglia disrupt mesolimbic reward circuitry in chronic pain by Taylor, Anna M W, Castonguay, Annie, Taylor, Alison J, Murphy, Niall P, Ghogha, Atefeh, Cook, Christopher, Xue, Lihua, Olmstead, Mary C, De Koninck, Yves, Evans, Christopher J, Cahill, Catherine M

“…Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease in opioid-evoked DA release in the ventral striatum, suggesting that…”
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Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System by Massaly, Nicolas, Copits, Bryan A., Wilson-Poe, Adrianne R., Hipólito, Lucia, Markovic, Tamara, Yoon, Hye Jean, Liu, Shiwei, Walicki, Marie C., Bhatti, Dionnet L., Sirohi, Sunil, Klaas, Amanda, Walker, Brendan M., Neve, Rachael, Cahill, Catherine M., Shoghi, Kooresh I., Gereau, Robert W., McCall, Jordan G., Al-Hasani, Ream, Bruchas, Michael R., Morón, Jose A.

“…Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose…”
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Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation by Cahill, Catherine M, Walwyn, Wendy, Taylor, Anna M.W, Pradhan, Amynah A.A, Evans, Christopher J

“…Mechanisms of opioid tolerance have focused on adaptive modifications within cells containing opioid receptors, defined here as cellular allostasis,…”
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Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents by Burma, Nicole E, Bonin, Robert P, Leduc-Pessah, Heather, Baimel, Corey, Cairncross, Zoe F, Mousseau, Michael, Shankara, Jhenkruthi Vijaya, Stemkowski, Patrick L, Baimoukhametova, Dinara, Bains, Jaideep S, Antle, Michael C, Zamponi, Gerald W, Cahill, Catherine M, Borgland, Stephanie L, De Koninck, Yves, Trang, Tuan

“…The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents,…”
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Neurobiology of opioid dependence in creating addiction vulnerability [version 1; peer review: 3 approved] by Evans, Christopher J, Cahill, Catherine M

“…Opioid drugs are potent modulators of many physiological and psychological processes. When given acutely, they can elicit the signature responses of euphoria…”
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Topography of microglial activation in sensory‐ and affect‐related brain regions in chronic pain by Taylor, Anna M.W., Mehrabani, Sadaf, Liu, Steve, Taylor, Alison J., Cahill, Catherine M.

“…Microglial activation in the spinal cord plays a central role in the development and maintenance of chronic pain after a peripheral nerve injury (PNI). There…”
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The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction by Kermath, B. A., Vanderplow, A. M., Bjornson, K. J., Seablom, E. N., Novak, A. M., Bernhardt, C. R., Cahill, M. E.

“…The neural molecular and biochemical response to stress is a distinct physiological process, and multiple lines of evidence indicate that the prefrontal cortex…”
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MEDIATOR25 Acts as an Integrative Hub for the Regulation of Jasmonate-Responsive Gene Expression in Arabidopsis by Çevik, Volkan, Kidd, Brendan N., Zhang, Peijun, Hill, Claire, Kiddle, Steve, Denby, Katherine J., Holub, Eric B., Cahill, David M., Manners, John M., Schenk, Peer M., Beynon, Jim, Kazan, Kemal

“…The PHYTOCHROME AND FLOWERING TIME1 gene encoding the MEDIATOR25 (MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate…”
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