Search Results - "Cagatay, Tolga"

Karyopherins in cancer by Çağatay, Tolga, Chook, Yuh Min

“…Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the…”
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Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits by Çağatay, Tolga, Turcotte, Marc, Elowitz, Michael B., Garcia-Ojalvo, Jordi, Süel, Gürol M.

“…Gene regulatory circuits with different architectures (patterns of regulatory interactions) can generate similar dynamics. This raises the question of why a…”
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Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins by Soniat, Michael, Cağatay, Tolga, Chook, Yuh Min

“…N-terminal tails of histones H3 and H4 are known to bind several different Importins to import the histones into the cell nucleus. However, it is not known…”
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Correlation of CRM1-NES affinity with nuclear export activity by Fu, Szu-Chin, Fung, Ho Yee Joyce, Cağatay, Tolga, Baumhardt, Jordan, Chook, Yuh Min

“…CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals…”
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Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone by Padavannil, Abhilash, Sarkar, Prithwijit, Kim, Seung Joong, Cagatay, Tolga, Jiou, Jenny, Brautigam, Chad A, Tomchick, Diana R, Sali, Andrej, D'Arcy, Sheena, Chook, Yuh Min

“…We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular…”
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Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex by Bhat, Prasanna, Aksenova, Vasilisa, Gazzara, Matthew, Rex, Emily A., Aslam, Sadaf, Haddad, Christina, Gao, Shengyan, Esparza, Matthew, Cagatay, Tolga, Batten, Kimberly, El Zahed, Sara S., Arnaoutov, Alexei, Zhong, Hualin, Shay, Jerry W., Tolbert, Blanton S., Dasso, Mary, Lynch, Kristen W., García-Sastre, Adolfo, Fontoura, Beatriz M. A.

“…Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade…”
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Localized cell death focuses mechanical forces during 3D patterning in a biofilm by Asally, Munehiro, Kittisopikul, Mark, Rué, Pau, Du, Yingjie, Hu, Zhenxing, Çağatay, Tolga, Robinson, Andra B, Lu, Hongbing, Garcia-Ojalvo, Jordi, Süel, Gürol M

“…From microbial biofilm communities to multicellular organisms, 3D macroscopic structures develop through poorly understood interplay between cellular processes…”
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p53 mutation as a source of aberrant β-catenin accumulation in cancer cells by CAGATAY, Tolga, OZTURK, Mehmet

“…beta-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF…”
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Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization by Pinarbasi, Emile S., Cağatay, Tolga, Fung, Ho Yee Joyce, Li, Ying C., Chook, Yuh Min, Thomas, Philip J.

“…ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons:…”
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Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X) by Gonzalez, Abner, Mannen, Taro, Çağatay, Tolga, Fujiwara, Ayano, Matsumura, Hiroyoshi, Niesman, Ashley B., Brautigam, Chad A., Chook, Yuh Min, Yoshizawa, Takuya

“…Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear…”
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Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling by Guo, Jianhui, Cagatay, Tolga, Zhou, Guangjin, Chan, Chih-Chiang, Blythe, Shelby, Suyama, Kaye, Zheng, Li, Pan, Kaifeng, Qian, Chiping, Hamelin, Richard, Thibodeau, Stephen N, Klein, Peter S, Wharton, Keith A, Liu, Wanguo

“…Mutation of Wnt signal antagonists Apc or Axin activates beta-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The…”
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LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins by Xu, Darui, Marquis, Kara, Pei, Jimin, Fu, Szu-Chin, Cağatay, Tolga, Grishin, Nick V, Chook, Yuh Min

“…Classical nuclear export signals (NESs) are short cognate peptides that direct proteins out of the nucleus via the CRM1-mediated export pathway. CRM1 regulates…”
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Circuit-level input integration in bacterial gene regulation by Espinar, Lorena, Dies, Marta, Çağatay, Tolga, Süel, Gürol M., Garcia-Ojalvo, Jordi

“…Gene regulatory circuits can receive multiple simultaneous inputs, which can enter the system through different locations. It is thus necessary to establish…”
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Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd) by Chan, Chih-Chiang, Zhang, Shu, Çagatay, Tolga, Wharton, Keith A.

“…Robust animal development, tissue homeostasis, and stem cell renewal requires precise control of the Wnt/β-catenin signaling axis. In the embryo of the fruit…”
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Temporal competition between differentiation programs determines cell fate choice by Kuchina, Anna, Espinar, Lorena, Çağatay, Tolga, Balbin, Alejandro O, Zhang, Fang, Alvarado, Alma, Garcia‐Ojalvo, Jordi, Süel, Gürol M

“…Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision‐making…”
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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis by Kehrer, Thomas, Cupic, Anastasija, Ye, Chengjin, Yildiz, Soner, Bouhaddou, Mehdi, Crossland, Nicholas A., Barrall, Erika A., Cohen, Phillip, Tseng, Anna, Çağatay, Tolga, Rathnasinghe, Raveen, Flores, Daniel, Jangra, Sonia, Alam, Fahmida, Mena, Ignacio, Aslam, Sadaf, Saqi, Anjali, Rutkowska, Magdalena, Ummadi, Manisha R., Pisanelli, Giuseppe, Richardson, R. Blake, Veit, Ethan C., Fabius, Jacqueline M., Soucheray, Margaret, Polacco, Benjamin J., Ak, Baran, Marin, Arturo, Evans, Matthew J., Swaney, Danielle L., Gonzalez-Reiche, Ana S., Sordillo, Emilia M., van Bakel, Harm, Simon, Viviana, Zuliani-Alvarez, Lorena, Fontoura, Beatriz M.A., Rosenberg, Brad R., Krogan, Nevan J., Martinez-Sobrido, Luis, García-Sastre, Adolfo, Miorin, Lisa

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins that inhibit host interferon responses. Among these, ORF6 antagonizes…”
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Determining University Students’ Smoking Habits and Awareness Levels About Thirdhand Smoke by Serap Salimoğlu, Hüseyin Tolga Çağatay, Recep Akdur

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Saccharomyces cerevisiae C1D is implicated in both non‐homologous DNA end joining and homologous recombination by Erdemir, Tuba, Bilican, Bilada, Cagatay, Tolga, Goding, Colin R., Yavuzer, Ugur

“…Summary C1D is a gamma‐irradiation inducible nuclear matrix protein that interacts with and activates the DNA‐dependent protein kinase (DNA‐PK) that is…”
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The effect of the compassion levels of healthcare workers on their psychological well-being by Demirel, Yüksel, Çağatay, Hüseyin Tolga, Ertuğrul, Bekir, Başaran, Esin, Salimoğlu, Serap

“…A sense of compassion has a core importance in health service delivery. Research on the psychological impact of being compassionate on healthcare workers is…”
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Cellular NS1-BP protein interacts with the mRNA export receptor NXF1 to mediate nuclear export of influenza virus M mRNAs by Zhang, Ke, Cagatay, Tolga, Xie, Dongqi, Angelos, Alexia E., Cornelius, Serena, Aksenova, Vasilisa, Aslam, Sadaf, He, Zhiyu, Esparza, Matthew, Vazhavilla, Ashley, Dasso, Mary, García-Sastre, Adolfo, Ren, Yi, Fontoura, Beatriz M.A.

“…Influenza A viruses have eight genomic RNAs that are transcribed in the host cell nucleus. Two of the viral mRNAs undergo alternative splicing. The M1 mRNA…”
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