Search Results - "Caffrey, Moya V"

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092 by Bahl, Ash, Barton, Patrick, Bowers, Keith, Caffrey, Moya V., Denton, Rebecca, Gilmour, Peter, Hawley, Shaun, Linannen, Tero, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Riley, Robert J., Roe, Emma, Springthorpe, Brian, Stein, Linda, Webborn, Peter

“…The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M. P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline, [1,2,3]triazolo[1,5- a]quinoxaline and [1,2,3]triazolo[5,1- c]benzotriazine derivatives by Abbott, Phillip A, Bonnert, Roger V, Caffrey, Moya V, Cage, Peter A, Cooke, Andrew J, Donald, David K, Furber, Mark, Hill, Steve, Withnall, Jane

“…General methods are descibed for the synthesis of mesoionic derivatives of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline,…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul

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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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