Search Results - "Caffrey, Conor"

Chemotherapy of schistosomiasis: present and future by Caffrey, Conor R

“…Schistosomiasis is a chronic parasitic disease in tropical and subtropical regions and is associated with a variety of clinical syndromes that may lead to…”
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Schistosomiasis and its treatment by Caffrey, Conor R

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Should the enzyme name ‘rhodesain’ be discontinued? by Steverding, Dietmar, Caffrey, Conor R.

“…•The term ‘rhodesain’ is tainted due to its association with Cecil Rhodes.•The protein sequence of rhodesain is essentially identical to that of brucipain.•The…”
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A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding by Wendt, George, Zhao, Lu, Chen, Rui, Liu, Chenxi, O'Donoghue, Anthony J, Caffrey, Conor R, Reese, Michael L, Collins, 3rd, James J

“…Schistosomiasis is a neglected tropical disease that infects 240 million people. With no vaccines and only one drug available, new therapeutic targets are…”
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Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies by Lucero, Bobby, Francisco, Karol R., Liu, Lawrence J., Caffrey, Conor R., Ballatore, Carlo

“…Whereas, historically, the majority of efforts toward small-molecule modulators of PPIs have largely focused on PPI inhibitors, there is growing evidence that…”
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Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis by Rojo-Arreola, Liliana, Long, Thavy, Asarnow, Dan, Suzuki, Brian M, Singh, Rahul, Caffrey, Conor R

“…The mevalonate pathway is essential in eukaryotes and responsible for a diversity of fundamental synthetic activities. 3-hydroxy-3-methylglutaryl coenzyme A…”
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Targeting proteasomes in infectious organisms to combat disease by Bibo‐Verdugo, Betsaida, Jiang, Zhenze, Caffrey, Conor R., O'Donoghue, Anthony J.

“…Proteasomes are multisubunit, energy‐dependent, proteolytic complexes that play an essential role in intracellular protein turnover. They are present in…”
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New insights into the machinery of blood digestion by ticks by Sojka, Daniel, Franta, Zdeněk, Horn, Martin, Caffrey, Conor R, Mareš, Michael, Kopáček, Petr

“…Highlights • Ticks digest blood intracellularly by a multi-enzyme system of cysteine and aspartic proteases. • A similar proteolytic machinery is employed by…”
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Anthelmintic Drug Discovery: Into the Future by Geary, Timothy G, Sakanari, Judy A, Caffrey, Conor R

“…The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs,…”
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Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics by Abriola, Laura, Hoyer, Denton, Caffrey, Conor R, Williams, David L, Yoshino, Timothy P, Vermeire, Jon J

“…Hookworms remain a major health burden in the developing world, with hundreds of millions currently afflicted by these blood-feeding parasites. There exists a…”
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Cysteine proteases during larval migration and development of helminths in their final host by Grote, Alexandra, Caffrey, Conor R, Rebello, Karina M, Smith, David, Dalton, John P, Lustigman, Sara

“…Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are…”
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From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis by Utzinger, Jürg, N’Goran, Eliézer K., Caffrey, Conor R., Keiser, Jennifer

“…Schistosomiasis is entrenched in social–ecological systems, since transmission is governed by human behaviour (e.g. unprotected surface water contacts) and…”
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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening by Abdulla, Maha-Hamadien, Ruelas, Debbie S, Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R, Williams, Janice, McKerrow, James H, Caffrey, Conor R

“…Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel…”
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Biomechanics of parasite migration within hosts by Yeh, Yi-Ting, del Álamo, Juan C., Caffrey, Conor R.

“…The quantification of parasite forces during migration in host environments elucidates critical biophysical mechanisms that support parasite survival and…”
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Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor by Abdulla, Maha-Hamadien, Lim, Kee-Chong, Sajid, Mohammed, McKerrow, James H, Caffrey, Conor R

“…Schistosomiasis is a chronic, debilitating parasitic disease infecting more than 200 million people and is second only to malaria in terms of public health…”
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Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation by Picard, Marion A L, Boissier, Jérôme, Roquis, David, Grunau, Christoph, Allienne, Jean-François, Duval, David, Toulza, Eve, Arancibia, Nathalie, Caffrey, Conor R, Long, Thavy, Nidelet, Sabine, Rohmer, Marine, Cosseau, Céline

“…Among more than 20,000 species of hermaphroditic trematodes, Schistosomatidae are unusual since they have evolved gonochorism. In schistosomes, sex is…”
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Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria by Singh, Vigyasa, Hada, Rahul Singh, Jain, Ravi, Vashistha, Manu, Kumari, Geeta, Singh, Snigdha, Sharma, Neha, Bansal, Meenakshi, Poonam, Zoltner, Martin, Caffrey, Conor R., Rathi, Brijesh, Singh, Shailja

“…Constant emergence of drug-resistant Plasmodium falciparum warrants urgent need for effective and inexpensive drugs. Herein, phthalimide (Pht) analogs…”
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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors by Fajtová, Pavla, Štefanić, Saša, Hradilek, Martin, Dvořák, Jan, Vondrášek, Jiří, Jílková, Adéla, Ulrychová, Lenka, McKerrow, James H, Caffrey, Conor R, Mareš, Michael, Horn, Martin

“…Blood flukes of the genus Schistosoma cause schistosomiasis, a parasitic disease that infects over 240 million people worldwide, and for which there is a need…”
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Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation by Yeh, Yi-Ting, Skinner, Danielle E, Criado-Hidalgo, Ernesto, Chen, Natalie Shee, Garcia-De Herreros, Antoni, El-Sakkary, Nelly, Liu, Lawrence, Zhang, Shun, Kandasamy, Adithan, Chien, Shu, Lasheras, Juan C, Del Álamo, Juan C, Caffrey, Conor R

“…The eggs of the parasitic blood fluke, Schistosoma, are the main drivers of the chronic pathologies associated with schistosomiasis, a disease of poverty…”
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Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors by Barbosa da Silva, Elany, Rocha, Débora A, Fortes, Isadora S, Yang, Wenqian, Monti, Ludovica, Siqueira-Neto, Jair L, Caffrey, Conor R, McKerrow, James, Andrade, Saulo F, Ferreira, Rafaela S

“…The cysteine proteases, cruzain and TbrCATL (rhodesain), are therapeutic targets for Chagas disease and Human African Trypanosomiasis, respectively. Among the…”
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