Search Results - "Cafarella, Tanya R"
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Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus
Published in The Journal of biological chemistry (06-07-2018)“…Innate immunity is critical in the early containment of influenza A virus (IAV) infection, and surfactant protein D (SP-D) plays a crucial role in the…”
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Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation
Published in Biochemistry (Easton) (26-11-2013)“…Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. Interactions of SP-D with…”
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Insights into the Architecture of the eIF2Bα/β/δ Regulatory Subcomplex
Published in Biochemistry (Easton) (03-06-2014)“…Eukaryotic translation initiation factor 2B (eIF2B), the guanine nucleotide exchange factor for the G-protein eIF2, is one of the main targets for the…”
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Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop
Published in Biochemistry (Easton) (08-08-2017)“…Lung surfactant proteins (SPs) play critical roles in surfactant function and innate immunity. SP-A and SP-D, members of the collectin family of C-type…”
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A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D
Published in The Journal of biological chemistry (03-08-2012)“…Pigs can act as intermediate hosts by which reassorted influenza A virus (IAV) strains can be transmitted to humans and cause pandemic influenza outbreaks. The…”
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Site-specific crosslinking of annexin proteins by 1,4-benzoquinone: a novel crosslinker for the formation of protein dimers and diverse protein conjugates
Published in Organic & biomolecular chemistry (21-06-2012)“…Annexin V (1) specifically binds to phosphatidylserine on apoptotic and necrotic cells as well as certain cancer cells, making it an attractive vehicle for the…”
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Molecular Mechanisms of Influenza Inhibition by Surfactant Protein D Revealed by Large-scale Molecular Dynamics Simulation
Published in Biochemistry (Easton) (13-11-2013)“…Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. SP-D interactions with highly…”
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