Quantification of torque teno virus (TTV) DNA in saliva and plasma samples in patients at short time before and after kidney transplantation

Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been su...

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Bibliographic Details
Published in:	Journal of oral microbiology Vol. 14; no. 1; p. 2008140
Main Authors:	Batista, Alexandre Mendes, Caetano, Matheus W., Stincarelli, Maria A., Mamana, Ana C., Zerbinati, Rodrigo Melim, Sarmento, Dmitry J. S., Gallottini, Marina, Caixeta, Rafael A. V., Medina-Pestana, José, Hasséus, Bengt, Zanella, Louise, Tozetto-Mendoza, Tania R., Giannecchini, Simone, Braz-Silva, Paulo H.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01-01-2022 Taylor & Francis Group
Subjects:	dynamics human virome immunosuppression load maintenance Microbiology Microbiology in the medical area Mikrobiologi inom det medicinska området Original rejection replication Saliva solid organ transplantation stem-cell transplantation torque teno torque teno virus torquetenovirus viremia virus immunosuppression solid organ transplantation torque teno virus Saliva
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Summary:	Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been suggested. to investigate the correlation between the TTV viral load and immune function in paired saliva and plasma samples in patients on kidney transplantation. TTV-DNA viral load was quantified in paired samples of saliva and plasma from 71 patients before and a short-time after renal-transplantation by real-time PCR. The data obtained from 213 paired samples showed a slight consistency in the comparison between saliva and plasma, with prevalence of TTV-DNA being 58%, 52% and 60% in saliva samples and 60%, 73% and 90% in plasma samples before and at 15-20 and 45-60 days after transplantation, respectively. Additionally, a high TTV viral load was observed in plasma at 15-20 and 45-60 days after transplantation compared to that observed in saliva at the same time. Overall, monitoring TTV-DNA in saliva samples could be an additional fast non-invasive option to assess the immune functionality in SOT populations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to the study
ISSN:	2000-2297 2000-2297
DOI:	10.1080/20002297.2021.2008140