Search Results - "Cady, Sarah D"

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers by Schmidt-Rohr, Klaus, Wang, Jun, Hong, Mei, DeGrado, William F, Cady, Sarah D, Soto, Cinque S

“…The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine and rimantadine. Resistance to…”
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Persistent Dopants and Phase Segregation in Organolead Mixed-Halide Perovskites by Rosales, Bryan A, Men, Long, Cady, Sarah D, Hanrahan, Michael P, Rossini, Aaron J, Vela, Javier

“…Organolead mixed-halide perovskites such as CH3NH3PbX3–aX′a (X, X′ = I, Br, Cl) are interesting semiconductors because of their low cost, high photovoltaic…”
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NMR Determination of Protein Partitioning into Membrane Domains with Different Curvatures and Application to the Influenza M2 Peptide by Wang, Tuo, Cady, Sarah D., Hong, Mei

“…The M2 protein of the influenza A virus acts both as a drug-sensitive proton channel and mediates virus budding through membrane scission. The segment…”
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Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel by Cady, Sarah D, Hong, Mei

“…The M2 protein of influenza A virus forms a transmembrane proton channel important for viral infection and replication. Amantadine blocks this channel, thus…”
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Structure and Function of the Influenza A M2 Proton Channel by Cady, Sarah D, Luo, Wenbin, Hu, Fanghao, Hong, Mei

“…The M2 protein of influenza A viruses forms a tetrameric pH-activated proton-selective channel that is targeted by the amantadine class of antiviral drugs. Its…”
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Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding by Cady, Sarah D., Mishanina, Tatiana V., Hong, Mei

“…The M2 proton channel of influenza A is the target of the antiviral drugs amantadine and rimantadine, whose effectiveness has been abolished by a single-site…”
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Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness by Hu, Fanghao, Luo, Wenbin, Cady, Sarah D., Hong, Mei

“…Membrane proteins change their conformations to respond to environmental cues, thus conformational plasticity is important for function. The influenza A M2…”
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Membrane-Dependent Oligomeric Structure and Pore Formation of a β-Hairpin Antimicrobial Peptide in Lipid Bilayers from Solid-State NMR by Mani, Rajeswari, Cady, Sarah D., Tang, Ming, Waring, Alan J., Lehrer, Robert I., Hong, Mei

“…We used solid-state NMR spectroscopy to investigate the oligomeric structure and insertion of protegrin-1 (PG-1), a β-hairpin antimicrobial peptide, in lipid…”
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Optical and EPR Detection of a Triplet Ground State Phenyl Nitrenium Ion by Qiu, Yunfan, Du, Lili, Cady, Sarah D., Phillips, David Lee, Winter, Arthur H.

“…Nitrenium ions are important reactive intermediates participating in the synthetic chemistry and biological processes. Little is known about triplet phenyl…”
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Specific Binding of Adamantane Drugs and Direction of Their Polar Amines in the Pore of the Influenza M2 Transmembrane Domain in Lipid Bilayers and Dodecylphosphocholine Micelles Determined by NMR Spectroscopy by Cady, Sarah D, Wang, Jun, Wu, Yibing, DeGrado, William F, Hong, Mei

“…The transmembrane domain of the influenza M2 protein (M2TM) forms a tetrameric proton channel important for the virus lifecycle. The proton-channel activity is…”
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Immobilization of the Influenza A M2 Transmembrane Peptide in Virus Envelope−Mimetic Lipid Membranes: A Solid-State NMR Investigation by Luo, Wenbin, Cady, Sarah D, Hong, Mei

“…The dynamic and structural properties of membrane proteins are intimately affected by the lipid bilayer. One property of membrane proteins is uniaxial…”
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Make Selenium Reactive Again: Activating Elemental Selenium for Synthesis of Metal Selenides Ranging from Nanocrystals to Large Single Crystals by Abusa, Yao, Yox, Philip, Cady, Sarah D., Viswanathan, Gayatri, Opare-Addo, Jemima, Smith, Emily A., Mudryk, Yaroslav, Lebedev, Oleg I., Perras, Frédéric A., Kovnir, Kirill

“…The inertness of elemental selenium is a significant obstacle in the synthesis of selenium-containing materials at low reaction temperatures. Over the years,…”
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Synthesis-enabled exploration of chiral and polar multivalent quaternary sulfides by Akopov, Georgiy, Hewage, Nethmi W, Yox, Philip, Viswanathan, Gayatri, Lee, Shannon J, Hulsebosch, Liam P, Cady, Sarah D, Paterson, Alexander L, Perras, Frédéric A, Xu, Wenqian, Wu, Kui, Mudryk, Yaroslav, Kovnir, Kirill

“…An innovative method of synthesis is reported for the large and diverse (RE) 6 (TM) x (Tt) 2 S 14 (RE = rare-earth, TM = transition metals, Tt = Si, Ge, and…”
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Cu2ZnSnS4 Nanorods Doped with Tetrahedral, High Spin Transition Metal Ions: Mn2+, Co2+, and Ni2 by Thompson, Michelle J, Blakeney, Kyle J, Cady, Sarah D, Reichert, Malinda D, Pilar-Albaladejo, Joselyn Del, White, Seth T, Vela, Javier

“…Because of its useful optoelectronic properties and the relative abundance of its elements, the quaternary semiconductor Cu2ZnSnS4 (CZTS) has garnered…”
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Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus by Wang, Jun, Cady, Sarah D, Balannik, Victoria, Pinto, Lawrence H, DeGrado, William F, Hong, Mei

“…Amantadine has been used for decades as an inhibitor of the influenza A virus M2 protein (AM2) in the prophylaxis and treatment of influenza A infections, but…”
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Lead‐Free Semiconductors: Soft Chemistry, Dimensionality Control, and Manganese‐Doping of Germanium Halide Perovskites by Men, Long, Rosales, Bryan A., Gentry, Noreen E., Cady, Sarah D., Vela, Javier

“…Lead halide perovskites have drawn enormous interest due to their exceptional photovoltaic and optoelectronic properties. However, the heavy metal lead is…”
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Effects of amantadine on the dynamics of membrane-bound influenza A M2 transmembrane peptide studied by NMR relaxation by Cady, Sarah D, Hong, Mei

“…The molecular motions of membrane proteins in liquid-crystalline lipid bilayers lie at the interface between motions in isotropic liquids and in solids…”
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Does Biochar Stabilize the Bioreactive Carbon Fractions of Swine Manure? by Banik, Chumki, Bakshi, Santanu, Andersen, Daniel S., Cady, Sarah D., Smith, Ryan G., Brown, Robert C.

“…The labile organic or bioreactive fraction in manure is the food and energy source that microbes continuously utilize. Biochar (BC) addition to manure…”
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Simultaneous extraction of multiple orientational constraints of membrane proteins by 13C-detected N–H dipolar couplings under magic angle spinning by Cady, Sarah D., Hong, Mei

“…A 13C-detected N–H dipolar coupling technique is introduced for uniaxially mobile membrane proteins for orientation determination using unoriented samples. For…”
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Determining the Orientation of Uniaxially Rotating Membrane Proteins Using Unoriented Samples:  A 2H, 13C, and 15N Solid-State NMR Investigation of the Dynamics and Orientation of a Transmembrane Helical Bundle by Cady, Sarah D, Goodman, Catherine, Tatko, Chad D, DeGrado, William F, Hong, Mei

“…Membrane protein orientation has traditionally been determined by NMR using mechanically or magnetically aligned samples. Here we show a new NMR approach that…”
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