Search Results - "Cady, Ernest B"

Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study by Thayyil, Sudhin, Dr, Sebire, Neil J, Prof, Chitty, Lyn S, Prof, Wade, Angie, PhD, Chong, WK, MD, Olsen, Oystein, FRCR, Gunny, Roxana S, FRCR, Offiah, Amaka C, PhD, Owens, Catherine M, FRCR, Saunders, Dawn E, FRCR, Scott, Rosemary J, FRCPath, Jones, Rod, MSc, Norman, Wendy, DCR, Addison, Shea, BSc, Bainbridge, Alan, PhD, Cady, Ernest B, FInstP, Vita, Enrico De, PhD, Robertson, Nicola J, PhD, Taylor, Andrew M, Prof

“…Summary Background Post-mortem MRI is a potential diagnostic alternative to conventional autopsy, but few large prospective studies have compared its accuracy…”
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Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis by Pauliah, Shreela S, Shankaran, Seetha, Wade, Angie, Cady, Ernest B, Thayyil, Sudhin

“…Although selective or whole body cooling combined with optimal intensive care improves outcomes following neonatal encephalopathy in high-income countries, the…”
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Cerebral Magnetic Resonance Biomarkers in Neonatal Encephalopathy: A Meta-analysis by Thayyil, Sudhin, Chandrasekaran, Manigandan, Taylor, Andrew, Bainbridge, Alan, Cady, Ernest B, Chong, W. K. Kling, Murad, Shahed, Omar, Rumana Z, Robertson, Nicola J

“…Accurate prediction of neurodevelopmental outcome in neonatal encephalopathy (NE) is important for clinical management and to evaluate neuroprotective…”
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Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia by Faulkner, Stuart, Bainbridge, Alan, Kato, Takenori, Chandrasekaran, Manigandan, Kapetanakis, Andrew B., Hristova, Mariya, Liu, Mengyan, Evans, Samantha, De Vita, Enrico, Kelen, Dorottya, Sanders, Robert D., Edwards, A. David, Maze, Mervyn, Cady, Ernest B., Raivich, Gennadij, Robertson, Nicola J.

“…Objective: Additional treatments for therapeutic hypothermia are required to maximize neuroprotection for perinatal asphyxial encephalopathy. We assessed…”
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White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants by Kendall, Giles S, Melbourne, Andrew, Johnson, Samantha, Price, David, Bainbridge, Alan, Gunny, Roxanna, Huertas-Ceballos, Angela, Cady, Ernest B, Ourselin, Sebastian, Marlow, Neil, Robertson, Nicola J

“…To determine (a) whether diffuse white matter injury of prematurity is associated with an increased choline (Cho)-to-creatine (Cr) ratio and a reduced…”
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Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications by Robertson, Nicola J, Thayyil, Sudhin, Cady, Ernest B, Raivich, Gennadij

“…Neonatal brain injury remains a devastating condition, with poor outcomes despite the institution of an effective neuroprotective strategy of therapeutic…”
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Improved reproducibility of MRS regional brain thermometry by 'amplitude-weighted combination' by Cady, Ernest B., Penrice, Juliet, Robertson, Nicola J.

“…Brain temperature is important in stroke and trauma. In birth asphyxia, hypothermia improves outcome, but local brain temperature information is needed to…”
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Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome by Lally, Peter J, Price, David L, Pauliah, Shreela S, Bainbridge, Alan, Kurien, Justin, Sivasamy, Neeraja, Cowan, Frances M, Balraj, Guhan, Ayer, Manjula, Satheesan, Kariyapilly, Ceebi, Sreejith, Wade, Angie, Swamy, Ravi, Padinjattel, Shaji, Hutchon, Betty, Vijayakumar, Madhava, Nair, Mohandas, Padinharath, Krishnakumar, Zhang, Hui, Cady, Ernest B, Shankaran, Seetha, Thayyil, Sudhin

“…Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and…”
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Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome by Iwata, Osuke, Iwata, Sachiko, Bainbridge, Alan, De Vita, Enrico, Matsuishi, Toyojiro, Cady, Ernest B., Robertson, Nicola J.

“…Following hypoxia-ischaemia (HI), an early biomarker of insult severity is desirable to target neuroprotective therapies to patients most likely to benefit;…”
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T2 at MR imaging is an objective quantitative measure of cerebral white matter signal intensity abnormality in preterm infants at term-equivalent age by Hagmann, Cornelia F, De Vita, Enrico, Bainbridge, Alan, Gunny, Roxanna, Kapetanakis, Andrew B, Chong, Wui K, Cady, Ernest B, Gadian, David G, Robertson, Nicola J

“…To compare quantitative T2 relaxometry of cerebral white matter (WM) with qualitative assessment of conventional T2-weighted magnetic resonance (MR) images, to…”
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Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet by Cady, Ernest B, Iwata, Osuke, Bainbridge, Alan, Wyatt, John S, Robertson, Nicola J

“…Phosphorus magnetic resonance spectroscopy (³¹P MRS) often reveals apparently normal brain metabolism in the first hours after intrapartum hypoxia-ischemia…”
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Delayed Whole-Body Cooling to 33 or 35{degrees}C and the Development of Impaired Energy Generation Consequential to Transient Cerebral Hypoxia-Ischemia in the Newborn Piglet by O'Brien, Frances E, Iwata, Osuke, Thornton, John S, Vita, Enrico De, Sellwood, Mark W, Iwata, Sachiko, Sakata, Yasuko S, Charman, Susan, Ordidge, Roger, Cady, Ernest B, Wyatt, John S, Robertson, Nicola J

“…OBJECTIVES. Fundamental questions remain about the precise temperature providing optimal neuroprotection after perinatal hypoxia-ischemia (HI). Furthermore, if…”
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Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia by Iwata, Osuke, Thornton, John S., Sellwood, Mark W., Iwata, Sachiko, Sakata, Yasuko, Noone, Martina A., O'Brien, Frances E., Bainbridge, Alan, De Vita, Enrico, Raivich, Gennadij, Peebles, Donald, Scaravilli, Francesco, Cady, Ernest B., Ordidge, Roger, Wyatt, John S., Robertson, Nicola J.

“…Hypothermia after perinatal hypoxia‐ischemia (HI) is neuroprotective; the precise brain temperature that provides optimal protection is unknown. To assess the…”
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Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model by ROBERTSON, Nicola J, FAULKNER, Stuart, HRISTOVA, Mariya, CADY, Ernest B, GRESSENS, Pierre, GOLAY, Xavier, RAIVICH, Gennadij, FLEISS, Bobbi, BAINBRIDGE, Alan, ANDORKA, Csilla, PRICE, David, POWELL, Elizabeth, LECKY-THOMPSON, Lucy, THEI, Laura, CHANDRASEKARAN, Manigandan

“…Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal encephalopathy still have adverse outcomes. Additional treatments are…”
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Superficial brain is cooler in small piglets: Neonatal hypothermia implications by Iwata, Sachiko, Iwata, Osuke, Thornton, John S., Shanmugalingam, Shanthi, Bainbridge, Alan, Peebles, Donald, Wyatt, John S., Cady, Ernest B., Robertson, Nicola J.

“…Objective Hypothermia was not neuroprotective in low body weight (BW) infants on subgroup analysis in a recent clinical trial of selective head cooling (SHC)…”
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Systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia by Kerenyi, Aron, Kelen, Dorottya, Faulkner, Stuart D., Bainbridge, Alan, Chandrasekaran, Manigandan, Cady, Ernest B., Golay, Xavier, Robertson, Nicola J.

“…Introduction: The precise temperature for optimal neuroprotection in infants with neonatal encephalopathy is unclear. Our aim was to assess systemic effects of…”
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Whole-body cooling in neonatal encephalopathy using phase changing material by Thayyil, Sudhin, Shankaran, Seetha, Wade, Angie, Cowan, Frances M, Ayer, Manju, Satheesan, Karayapally, Sreejith, Ceebi, Eyles, Hannah, Taylor, Andrew M, Bainbridge, Alan, Cady, Ernest B, Robertson, Nicola J, Price, David, Balraj, Guhan

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“Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets by Iwata, Osuke, Iwata, Sachiko, Thornton, John S, De Vita, Enrico, Bainbridge, Alan, Herbert, Linda, Scaravilli, Francesco, Peebles, Donald, Wyatt, John S, Cady, Ernest B, Robertson, Nicola J

“…Abstract Objective: For optimal neuroprotection following transient perinatal hypoxia–ischaemia (HI), therapy should start before overt secondary energy…”
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Regional neonatal brain absolute thermometry by 1H MRS by Bainbridge, Alan, Kendall, Giles S., Vita, Enrico De, Hagmann, Cornelia, Kapetanakis, Andrew, Cady, Ernest B., Robertson, Nicola J.

“…Therapeutic hypothermia is standard care for infants with moderate to severe encephalopathy. 1H MRS thermometry (MRSt) measures regional brain absolute…”
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Comparative Prognostic Utilities of Early Quantitative Magnetic Resonance Imaging Spin-Spin Relaxometry and Proton Magnetic Resonance Spectroscopy in Neonatal Encephalopathy by Shanmugalingam, Shanthi, Thornton, John S, Iwata, Osuke, Bainbridge, Alan, O'Brien, Frances E, Priest, Andrew N, Ordidge, Roger J, Cady, Ernest B, Wyatt, John S, Robertson, Nicola J

“…We sought to compare the prognostic utilities of early MRI spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy…”
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