Search Results - "Cadot, Bruno"

Nuclear positioning: A matter of life by Bruno, Cadot

“…Cell organization, and in particular how organelles are distributed in the cell, is often used by physio-pathologists to visually identify cell types in an…”
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TGFβ signaling curbs cell fusion and muscle regeneration by Girardi, Francesco, Taleb, Anissa, Ebrahimi, Majid, Datye, Asiman, Gamage, Dilani G., Peccate, Cécile, Giordani, Lorenzo, Millay, Douglas P., Gilbert, Penney M., Cadot, Bruno, Le Grand, Fabien

“…Muscle cell fusion is a multistep process involving cell migration, adhesion, membrane remodeling and actin-nucleation pathways to generate multinucleated…”
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Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells by Gimpel, Petra, Lee, Yin Loon, Sobota, Radoslaw M., Calvi, Alessandra, Koullourou, Victoria, Patel, Rutti, Mamchaoui, Kamel, Nédélec, François, Shackleton, Sue, Schmoranzer, Jan, Burke, Brian, Cadot, Bruno, Gomes, Edgar R.

“…The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation…”
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A system for studying mechanisms of neuromuscular junction development and maintenance by Vilmont, Valérie, Cadot, Bruno, Ouanounou, Gilles, Gomes, Edgar R

“…The neuromuscular junction (NMJ), a cellular synapse between a motor neuron and a skeletal muscle fiber, enables the translation of chemical cues into physical…”
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Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development by Gomes, Edgar R, Marazzi, Giovanna, Mitchell, Kathryn J, Cadot, Bruno, Parlakian, Ara, Sassoon, David A, Besson, Vanessa, Pannérec, Alice

“…In postnatal skeletal muscle, satellite cells are resident myogenic progenitors responsible for muscle growth and regeneration. A distinct population of…”
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Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies by Rose, Nicolas, Estrada Chavez, Berenice, Sonam, Surabhi, Nguyen, Thao, Grenci, Gianluca, Bigot, Anne, Muchir, Antoine, Ladoux, Benoît, Cadot, Bruno, Le Grand, Fabien, Trichet, Léa

“…Quantification of skeletal muscle functional contraction is essential to assess the outcomes of therapeutic procedures for neuromuscular disorders. Muscle…”
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Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle by Roman, William, Martins, João P., Carvalho, Filomena A., Voituriez, Raphael, Abella, Jasmine V. G., Santos, Nuno C., Cadot, Bruno, Way, Michael, Gomes, Edgar R.

“…Nuclear movements are important for multiple cellular functions, and are driven by polarized forces generated by motor proteins and the cytoskeleton. During…”
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Science during lockdown - from virtual seminars to sustainable online communities by Bottanelli, Francesca, Cadot, Bruno, Campelo, Felix, Curran, Scott, Davidson, Patricia M, Dey, Gautam, Raote, Ishier, Straube, Anne, Swaffer, Matthew P

“…The COVID-19 pandemic has disrupted traditional modes of scientific communication. In-person conferences and seminars have been cancelled and most scientists…”
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Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation by Lemerle, Eline, Lainé, Jeanne, Benoist, Marion, Moulay, Gilles, Bigot, Anne, Labasse, Clémence, Madelaine, Angéline, Canette, Alexis, Aubin, Perrine, Vallat, Jean-Michel, Romero, Norma B, Bitoun, Marc, Mouly, Vincent, Marty, Isabelle, Cadot, Bruno, Picas, Laura, Vassilopoulos, Stéphane

“…Excitation-contraction coupling requires a highly specialized membrane structure, the triad, composed of a plasma membrane invagination, the T-tubule,…”
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Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations by Le Dour, Caroline, Chatzifrangkeskou, Maria, Macquart, Coline, Magiera, Maria M., Peccate, Cécile, Jouve, Charlène, Virtanen, Laura, Heliö, Tiina, Aalto-Setälä, Katriina, Crasto, Silvia, Cadot, Bruno, Cardoso, Déborah, Mougenot, Nathalie, Adesse, Daniel, Di Pasquale, Elisa, Hulot, Jean-Sébastien, Taimen, Pekka, Janke, Carsten, Muchir, Antoine

“…Mutations in the lamin A/C gene ( LMNA ) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2…”
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Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3 by Cadot, Bruno, Gache, Vincent, Vasyutina, Elena, Falcone, Sestina, Birchmeier, Carmen, Gomes, Edgar R

“…Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form…”
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Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation by Darrigrand, Jean-François, Valente, Mariana, Comai, Glenda, Martinez, Pauline, Petit, Maxime, Nishinakamura, Ryuichi, Osorio, Daniel S, Renault, Gilles, Marchiol, Carmen, Ribes, Vanessa, Cadot, Bruno

“…The establishment of separated pulmonary and systemic circulation in vertebrates, via cardiac outflow tract (OFT) septation, is a sensitive developmental…”
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GDF5 as a rejuvenating treatment for age-related neuromuscular failure by Massiré, Traoré, Chiara, Noviello, Amélie, Vergnol, Christel, Gentil, Marius, Halliez, Lucile, Saillard, Maxime, Gelin, Anne, Forand, Mégane, Lemaitre, Zoheir, Guesmia, Bruno, Cadot, Eriky, Caldas, Benjamin, Marty, Nathalie, Mougenot, Julien, Messéant, Laure, Strochlic, Jeremy, Sadoine, Lofti, Slimani, Ariane, Jolly, Pierre, De la Grange, Jean-Yves, Hogrel, France, Pietri-Rouxel, Sestina, Falcone

“…Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during ageing, which results in increased inability and death; however, no…”
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Development of versatile allele-specific siRNAs able to silence all the dominant dynamin 2 mutations by Dudhal, Swati, Mekzine, Lylia, Prudhon, Bernard, Soocheta, Karishma, Cadot, Bruno, Mamchaoui, Kamel, Trochet, Delphine, Bitoun, Marc

“…Dominant centronuclear myopathy (CNM) is a rare form of congenital myopathy associated with a wide clinical spectrum, from severe neonatal to milder adult…”
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A system to study mechanisms of neuromuscular junction development and maintenance by Vilmont, Valérie, Cadot, Bruno, Ouanounou, Gilles, Gomes, Edgar R.

“…The neuromuscular junction (NMJ), a cellular synapse between a motor neuron and a skeletal muscle fiber, enables the translation of chemical cues into physical…”
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Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS by Vilmont, Valérie, Cadot, Bruno, Vezin, Elsa, Le Grand, Fabien, Gomes, Edgar R.

“…The neuromuscular junction (NMJ) allows the transformation of a neuronal message into a mechanical force by muscle contraction and is the target of several…”
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Fast, multi-dimensional and simultaneous kymograph-like particle dynamics (SkyPad) analysis by Cadot, Bruno, Gache, Vincent, Gomes, Edgar R

“…Kymograph analysis is a method widely used by researchers to analyze particle dynamics in one dimensional (1D) trajectories. Here we provide a Visual…”
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Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsies by Labasse, Clémence, Brochier, Guy, Taratuto, Ana-Lia, Cadot, Bruno, Rendu, John, Monges, Soledad, Biancalana, Valérie, Quijano-Roy, Susana, Bui, Mai Thao, Chanut, Anaïs, Madelaine, Angéline, Lacène, Emmanuelle, Beuvin, Maud, Amthor, Helge, Servais, Laurent, de Feraudy, Yvan, Erro, Marcela, Saccoliti, Maria, Neto, Osorio Abath, Fauré, Julien, Lannes, Béatrice, Laugel, Vincent, Coppens, Sandra, Lubieniecki, Fabiana, Bello, Ana Buj, Laing, Nigel, Evangelista, Teresinha, Laporte, Jocelyn, Böhm, Johann, Romero, Norma B

“…Abstract Nemaline myopathy (NM) is a muscle disorder with broad clinical and genetic heterogeneity. The clinical presentation of affected individuals ranges…”
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The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles by Rufini, Stefano, Lena, Anna Maria, Cadot, Bruno, Mele, Sonia, Amelio, Ivano, Terrinoni, Alessandro, Desideri, Alessandro, Melino, Gerry, Candi, Eleonora

“…We have performed a biochemical analysis of p63-SAM domain preferences in lipid binding. We have identified the ganglioside GM1 as a high affinity interactor,…”
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Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells by CADOT, Bruno, BRUNETTI, Mirko, COPPARI, Sabina, FEDELI, Silvia, DE RINALDIS, Emanuele, DELLO RUSSO, Claudio, GALLINARI, Paola, DE FRANCESCO, Raffaele, STEINKÜHLER, Christian, FILOCAMO, Gessica

“…We investigated the role of histone deacetylase 4 (HDAC4) using RNA interference (RNAi) and knockout cells to specifically address its role in cell cycle…”
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