Search Results - "Cadoret, Axelle"

Origins and functions of liver myofibroblasts by Lemoinne, Sara, Cadoret, Axelle, El Mourabit, Haquima, Thabut, Dominique, Housset, Chantal

“…Myofibroblasts combine the matrix-producing functions of fibroblasts and the contractile properties of smooth muscle cells. They are the main effectors of…”
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Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease by Majdi, Amine, Aoudjehane, Lynda, Ratziu, Vlad, Islam, Tawhidul, Afonso, Marta B., Conti, Filomena, Mestiri, Taïeb, Lagouge, Marie, Foufelle, Fabienne, Ballenghien, Florine, Ledent, Tatiana, Moldes, Marthe, Cadoret, Axelle, Fouassier, Laura, Delaunay, Jean-Louis, Aït-Slimane, Tounsia, Courtois, Gilles, Fève, Bruno, Scatton, Olivier, Prip-Buus, Carina, Rodrigues, Cecília M.P., Housset, Chantal, Gautheron, Jérémie

“…In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting…”
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Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles by Lemoinne, Sara, Cadoret, Axelle, Rautou, Pierre‐Emmanuel, El Mourabit, Haquima, Ratziu, Vlad, Corpechot, Christophe, Rey, Colette, Bosselut, Nelly, Barbu, Véronique, Wendum, Dominique, Feldmann, Gérard, Boulanger, Chantal, Henegar, Corneliu, Housset, Chantal, Thabut, Dominique

“…Liver fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progression of liver diseases to cirrhosis. In the present…”
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New targets of β-catenin signaling in the liver are involved in the glutamine metabolism by CADORET, Axelle, OVEJERO, Christine, TERRIS, Benoit, SOUIL, Evelyne, LEVY, Laurence, LAMERS, Wouter H, KITAJEWSKI, Jan, KAHN, Axel, PERRET, Christine

“…Inappropriate activation of the Wnt/beta-catenin signaling has been implicated in the development of hepatocellular carcinoma (HCC), but exactly how…”
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Distinct proteomic features of two fibrogenic liver cell populations: Hepatic stellate cells and portal myofibroblasts by Bosselut, Nelly, Housset, Chantal, Marcelo, Paulo, Rey, Colette, Burmester, Thorsten, Vinh, Jöelle, Vaubourdolle, Michel, Cadoret, Axelle, Baudin, Bruno

“…In chronic liver diseases, the accumulation of extracellular matrix leading to fibrosis is caused by myofibroblasts, the origins of which are debatable. We…”
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Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis by Lei, Lin, Bruneau, Alix, El Mourabit, Haquima, Guégan, Justine, Folseraas, Trine, Lemoinne, Sara, Karlsen, Tom Hemming, Hoareau, Bénédicte, Morichon, Romain, Gonzalez‐Sanchez, Ester, Goumard, Claire, Ratziu, Vlad, Charbord, Pierre, Gautheron, Jérémie, Tacke, Frank, Jaffredo, Thierry, Cadoret, Axelle, Housset, Chantal

“…Background and Aims In liver fibrosis, myofibroblasts derive from HSCs and as yet undefined mesenchymal cells. We aimed to identify portal mesenchymal…”
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Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression by Loeuillard, Emilien, El Mourabit, Haquima, Lei, Lin, Lemoinne, Sara, Housset, Chantal, Cadoret, Axelle

“…Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal mesenchymal…”
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Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice by Gonzalez-Sanchez, Ester, El Mourabit, Haquima, Jager, Marion, Clavel, Marie, Moog, Sophie, Vaquero, Javier, Ledent, Tatiana, Cadoret, Axelle, Gautheron, Jérémie, Fouassier, Laura, Wendum, Dominique, Chignard, Nicolas, Housset, Chantal

“…Cholangiopathies are chronic liver diseases in which damaged cholangiocytes trigger a proinflammatory and profibrotic reaction. The nuclear vitamin D receptor…”
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Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice by Firrincieli, Delphine, Zúñiga, Silvia, Rey, Colette, Wendum, Dominique, Lasnier, Elisabeth, Rainteau, Dominique, Braescu, Thomas, Falguières, Thomas, Boissan, Mathieu, Cadoret, Axelle, Housset, Chantal, Chignard, Nicolas

“…Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR),…”
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Role of Angiogenesis in the Pathogenesis of NAFLD by Lei, Lin, Ei Mourabit, Haquima, Housset, Chantal, Cadoret, Axelle, Lemoinne, Sara

“…Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and…”
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Down-regulation of NF-κB activity and NF-κB p65 subunit expression by ras and polyoma middle T oncogenes in human colonic Caco-2 cells by CADORET, A, BERTRAND, F, BARON-DELAGE, S, LEVY, P, COURTOIS, G, GESPACH, C, CAPEAU, J, CHERQUI, G

“…The products of ras and src proto-oncogenes are frequently activated in a constitutive state in human colorectal cancer. In this study we attempted to…”
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Culture Model of Rat Portal Myofibroblasts by El Mourabit, Haquima, Loeuillard, Emilien, Lemoinne, Sara, Cadoret, Axelle, Housset, Chantal

“…Myofibroblasts are matrix-producing cells with contractile properties, usually characterized by de novo expression of alpha-smooth muscle actin, that arise in…”
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Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation by DESBOIS-MOUTHON, Christèle, CADORET, Axelle, BILVET-VAN EGGELPOËL, Marie-José, BERTRAND, France, CHERQUI, Gisèle, PERRET, Christine, CAPEAU, Jacqueline

“…We examined the interplay between the insulin/IGF-1-and beta -catenin-regulated pathways, both of which are suspected to play a role in hepatocarcinogenesis…”
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Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout by Desbois-Mouthon, Christèle, Wendum, Dominique, Cadoret, Axelle, Rey, Colette, Leneuve, Patricia, Blaise, Annick, Housset, Chantal, Tronche, François, Le Bouc, Yves, Holzenberger, Martin

“…ABSTRACT Recent evidence indicates that growth hormone (GH) is involved in liver regeneration. To test whether insulin‐like growth factor I (IGF‐I) mediates…”
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Hepatomegaly in transgenic mice expressing an oncogenic form of β-catenin by CADORET, Axelle, OVEJERO, Christine, SAADI-KHEDDOUCI, Sihem, SOUIL, Evelyne, FABRE, Monique, ROMAGNOLO, Béatrice, KAHN, Axel, PERRET, Christine

“…Inappropriate activation of the Wnt/beta-catenin signaling, resulting mainly from activating mutations of the beta-catenin gene, has been implicated recently…”
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IGF-1R Contributes to Stress-Induced Hepatocellular Damage in Experimental Cholestasis by Cadoret, Axelle, Rey, Colette, Wendum, Dominique, Elriz, Khaldoun, Tronche, François, Holzenberger, Martin, Housset, Chantal

“…The insulin-like growth factor type 1 receptor (IGF-1R) controls aging and cellular stress, both of which play major roles in liver disease. Stimulation of…”
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GSK-3β inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression by Beurel, Eléonore, Kornprobst, Michel, Blivet-Van Eggelpoël, Marie-José, Ruiz-Ruiz, Carmen, Cadoret, Axelle, Capeau, Jacqueline, Desbois-Mouthon, Christèle

“…Lithium exerts neuroprotective actions that involve the inhibition of glycogen synthase kinase-3β (GSK-3β). Otherwise, recent studies suggest that sustained…”
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Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells by Desbois-Mouthon, Christèle, Blivet-Van Eggelpoël, Marie-José, Beurel, Eléonore, Boissan, Mathieu, Delélo, Roland, Cadoret, Axelle, Capeau, Jacqueline

“…It has been reported that upstream components of the insulin-like growth factor (IGF) signaling axis could be overexpressed during hepatocarcinogenesis in…”
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Distinct proteomic features of two fibrogenic liver cell populations: Hepatic stellate cells and portal myofibroblasts by Bosselut, Nelly, Housset, Chantal, Marcelo, Paulo, Rey, Colette, Burmester, Thorsten, Vinh, Jöelle, Vaubourdolle, Michel, Cadoret, Axelle, Baudin, Bruno

“…This article was originally published in Proteomics 2010, 10, 1017–1028, DOI 10.1002/pmic.200900257…”
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A Role for Nuclear Factor κB in the Antiapoptotic Function of Insulin by Bertrand, France, Atfi, Azeddine, Cadoret, Axelle, L'Allemain, Gilles, Robin, Hélène, Lascols, Olivier, Capeau, Jacqueline, Cherqui, Gisèle

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