Search Results - "Cadieux, C"

Effects of Both Inherent Chemical Structure and Environment Conditions on the Enzyme‐Small Molecule Relationship of a Non‐Oxime Reactivator of Organophosphorus‐Inhibited Human Acetylcholinesterase by Sriraman, Aishwarya, Lee, Hannah, Cadieux, C. L.

“…Organophosphorus (OP) nerve agents and pesticides inhibit the enzyme acetylcholinesterase (AChE) via a covalent interaction at the active site, resulting in a…”
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Disentangling trophic relationships in a High Arctic tundra ecosystem through food web modeling by Legagneux, P, Gauthier, G, Berteaux, D, Bêty, J, Cadieux, M.-C, Bilodeau, F, Bolduc, E, McKinnon, L, Tarroux, A, Therrien, J.-F, Morissette, L, Krebs, C. J

“…Determining the manner in which food webs will respond to environmental changes is difficult because the relative importance of top-down vs. bottom-up forces…”
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Characterization of Humanized Mouse Model of Organophosphate Poisoning and Detection of Countermeasures via MALDI-MSI by Tressler, Caitlin M, Wadsworth, Benjamin, Carriero, Samantha, Dillman, Natalie, Crawford, Rachel, Hahm, Tae-Hun, Glunde, Kristine, Cadieux, C Linn

“…Organophosphoate (OP) chemicals are known to inhibit the enzyme acetylcholinesterase (AChE). Studying OP poisoning is difficult because common small animal…”
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Developing a Prenatal Acute Exposure and Medical Countermeasure Evaluation Model for Organophosphate Compounds in a Genetically Modified Mouse by Herrera, Eric, Barry, Timothy, Sriraman, Aishwarya, Brecht, Karen, DeBus, Sandra, Ma, Ki, Mccarren, Hilary, Cadieux, C. L.

“…Organophosphate (OPs) compounds make up the most common class of pesticides as well as chemical warfare nerve agents (CWNA), all of which covalently inhibit…”
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Arctic ecosystem structure and functioning shaped by climate and herbivore body size by Legagneux, P., Gauthier, G., Lecomte, N., Schmidt, N. M., Reid, D., Cadieux, M-C., Berteaux, D., Bêty, J., Krebs, C. J., Ims, R. A., Yoccoz, N. G., Morrison, R. I. G., Leroux, S. J., Loreau, M., Gravel, D.

“…Understanding how climate change will impact whole ecosystems, rather than single species within them, remains challenging. Now, research into the direct and…”
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Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning by Gupta, Vibhor, Cadieux, C Linn, McMenamin, Deirdre, Medina-Jaszek, C Angelica, Arif, Muhammad, Ahonkhai, Omua, Wielechowski, Erik, Taheri, Maryam, Che, Yan, Goode, Tamara, Limberis, Maria P, Li, Mingyao, Cerasoli, Douglas M, Tretiakova, Anna P, Wilson, James M

“…Rare diseases defined by genetic mutations are classic targets for gene therapy. More recently, researchers expanded the use of gene therapy in non-clinical…”
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The magnetic field and multiple planets of the young dwarf AU Mic by Donati, J-F, Cristofari, P I, Finociety, B, Klein, B, Moutou, C, Gaidos, E, Cadieux, C, Artigau, E, Correia, A C M, Boué, G, Cook, N J, Carmona, A, Lehmann, L T, Bouvier, J, Martioli, E, Morin, J, Fouqué, P, Delfosse, X, Doyon, R, Hébrard, G, Alencar, S H P, Laskar, J, Arnold, L, Petit, P, Kóspál, Á, Vidotto, A, Folsom, C P, collaboration, the S L S

“…ABSTRACT In this paper, we present an analysis of near-infrared spectropolarimetric and velocimetric data of the young M dwarf AU Mic, collected with SPIRou at…”
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Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents by Zhang, Peng, Liu, Erik J, Tsao, Caroline, Kasten, Shane A, Boeri, Michael V, Dao, Thuy L, DeBus, Sandra J, Cadieux, C Linn, Baker, Cetara A, Otto, Tamara C, Cerasoli, Douglas M, Chen, Yantao, Jain, Priyesh, Sun, Fang, Li, Wenchen, Hung, Hsiang-Chieh, Yuan, Zhefan, Ma, Jinrong, Bigley, Andrew N, Raushel, Frank M, Jiang, Shaoyi

“…Nerve agents are a class of organophosphorus compounds (OPs) that blocks communication between nerves and organs. Because of their acute neurotoxicity, it is…”
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Magnetic fields and rotation periods of M dwarfs from SPIRou spectra by Donati, J-F, Lehmann, L T, Cristofari, P I, Fouqué, P, Moutou, C, Charpentier, P, Ould-Elhkim, M, Carmona, A, Delfosse, X, Artigau, E, Alencar, S H P, Cadieux, C, Arnold, L, Petit, P, Morin, J, Forveille, T, Cloutier, R, Doyon, R, Hébrard, G

“…ABSTRACT We present near-infrared spectropolarimetric observations of a sample of 43 weakly to moderately active M dwarfs, carried with SPIRou at the…”
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Monitoring the young planet host V1298 Tau with SPIRou: planetary system and evolving large-scale magnetic field by Finociety, B, Donati, J-F, Cristofari, P I, Moutou, C, Cadieux, C, Cook, N J, Artigau, E, Baruteau, C, Debras, F, Fouqué, P, Bouvier, J, Alencar, S H P, Delfosse, X, Grankin, K, Carmona, A, Petit, P, Kóspál, Á

“…ABSTRACT We report results of a spectropolarimetric monitoring of the young Sun-like star V1298 Tau based on data collected with the near-infrared…”
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Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach by Bennion, Brian J., Malfatti, Michael A., Be, Nicholas A., Enright, Heather A., Hok, Saphon, Cadieux, C. Linn, Carpenter, Timothy S., Lao, Victoria, Kuhn, Edward A., McNerney, M. Windy, Lightstone, Felice C., Nguyen, Tuan H., Valdez, Carlos A.

“…Nerve agents have experienced a resurgence in recent times with their use against civilian targets during the attacks in Syria (2012), the poisoning of Sergei…”
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Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents by Cadieux, C. Linn, Wang, Haoyu, Zhang, Yuchen, Koenig, Jeffrey A., Shih, Tsung-Ming, McDonough, John, Koh, John, Cerasoli, Douglas

“…Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule…”
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Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice by Marrero-Rosado, Brenda M, Stone, Michael F, de Araujo Furtado, Marcio, Schultz, Caroline R, Cadieux, C Linn, Lumley, Lucille A

“…The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is…”
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Purification, characterization, and N‐glycosylation of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures by Corbin, Jasmine M., Kailemia, Muchena J., Cadieux, C. Linn, Alkanaimsh, Salem, Karuppanan, Kalimuthu, Rodriguez, Raymond L., Lebrilla, Carlito B., Cerasoli, Douglas M., McDonald, Karen A., Nandi, Somen

“…Recombinant butyrylcholinesterase produced in a metabolically regulated transgenic rice cell culture (rrBChE) was purified to produce a highly pure (95%),…”
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Treatment of Organophosphorus Poisoning with 6‑Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase by Clay, William K., Buck, Anne K., He, Yiran, Hernández Sánchez, Dalyanne N., Ward, Nathan A., Lear, Jeremy M., Nguyen, Kenny Q., Clark, Benjamin H., Sapia, Ryan J., Lalisse, Remy F., Sriraman, Aishwarya, Cadieux, C. Linn, McElroy, Craig A., Callam, Christopher S., Hadad, Christopher M.

“…Organophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE), creating a cholinergic crisis in which death can occur. The phosphylated serine residue…”
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Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication by Cerasoli, Douglas M., Armstrong, Stuart J., Reeves, Tony E., Hodgins, Sean M., Kasten, Shane A., Lee-Stubbs, Robyn B., Cadieux, C. Linn, Otto, Tamara C., Capacio, Benedict R., Lenz, David E.

“…[Display omitted] Human butyrylcholinesterase (E.C. 3.1.1.8) purified from blood plasma has previously been shown to provide protection against up to five and…”
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Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase by Tsai, Ping-Chuan, Bigley, Andrew, Li, Yingchun, Ghanem, Eman, Cadieux, C. Linn, Kasten, Shane A, Reeves, Tony E, Cerasoli, Douglas M, Raushel, Frank M

“…Organophosphorus compounds include many synthetic, neurotoxic substances that are commonly used as insecticides. The toxicity of these compounds is due to…”
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Patient and Caregiver Perspectives on Care-Seeking During a Vaso-Occlusive Crisis in Sickle Cell Disease: Results from Qualitative Interviews in Canada by Durgam, Neha, Brion, Triza, Lewis, Hannah B, Tinga, Biba, Sanon, Wilson, Lundie, Mark, Cadieux, Chantal

“…There is little research on care-seeking preferences during active pain crises for sickle cell disease (SCD) patients and their caregivers. The objective of…”
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The role of genetic background in susceptibility to chemical warfare nerve agents across rodent and non-human primate models by Matson, Liana M., McCarren, Hilary S., Cadieux, C. Linn, Cerasoli, Douglas M., McDonough, John H.

“…Genetics likely play a role in various responses to nerve agent exposure, as genetic background plays an important role in behavioral, neurological, and…”
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Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents by Geyer, Brian C., Kannan, Latha, Garnaud, Pierre-Emmanuel, Broomfield, Clarence A., Cadieux, C. Linn, Cherni, Irene, Hodgins, Sean M., Kasten, Shane A., Kelley, Karli, Kilbourne, Jacquelyn, Oliver, Zeke P., Otto, Tamara C., Puffenberger, Ian, Reeves, Tony E., Robbins, Neil, Woods, Ryan R., Soreq, Hermona, Lenz, David E., Cerasoli, Douglas M., Mor, Tsafrir S., Arntzen, Charles J.

“…The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to…”
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