Search Results - "Cadet, Dimitri"

TMET-37. TARGETING LIPID MEDIATED NON-CANONICAL CELL DEATH IN MALIGNANT GLIOMA by Salinas, Jennifer, Cadet, Dimitri, Smolev, Sarina, Iyer, Dhruva, Loo, Caitlyn, Lee, Weaverly, Dixon, Scott, Nathanson, David

“…Abstract Resistance to canonical cell death mechanisms (e.g. apoptosis) is a hallmark of glioma and consequently driving the dismal outcomes of patients with…”
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DDDR-43. ERAS-801 IS A SELECTIVE BRAIN-PENETRANT EGFR INHIBITOR WITH IMPROVED ACTIVITY AGAINST EGFR EXTRACELLULAR DOMAIN-MUTANT GLIOBLASTOMA by Okobi, Quincy, Cadet, Dimitri, Urner, Lorenz, Jung, Michael, Cloughesy, Timothy, Nathanson, David

“…Abstract Epidermal growth factor receptor (EGFR) is a driver of nearly 50% of glioblastoma (GBM), yet EGFR inhibitors have failed in GBM (e.g., erlotinib,…”
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CSIG-24. BRAIN MICROENVIRONMENT-DEPENDENT NEURODEVELOPMENTAL LINEAGE PLASTICITY PROMOTES ADAPTATION TO ONCOGENE INHIBITION IN MALIGNANT GLIOMAS by Cadet, Dimitri, Andrasz, Cassidy, Bayley, Nicholas, Fazzari, Elisa, Fernandez, Elizabeth, Okobi, Quincy, Graeber, Thomas, Bhaduri, Aparna, Cloughesy, Timothy, Nathanson, David

“…Abstract Phenotypic plasticity drives non-genetic tumor adaptation in response to various microenvironmental and therapeutic pressures, consequently promoting…”
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STEM-14. INTEGRATED ANALYSIS OF GLIOBLASTOMA PROGENITOR SUBTYPES REVEALS A TUMOR-DERIVED STEM CELL POPULATION WITH NEURAL AND VASCULAR POTENTIAL by Fazzari, Elisa, Azizad, Daria, Li, Matthew, Yu, Kwanha, Ge, Weihong, Nano, Patricia, Kan, Ryan, Soto, Jose, Crouch, Elizabeth, Raleigh, David, Cadet, Dimitri, Tse, Christopher, Tum, Andrew, Bayley, Nicholas, Deneen, Benjamin, Patel, Kunal, Nathanson, David, Bhaduri, Aparna

“…Abstract Glioblastoma (GBM) exhibits a vast heterogeneity in cell types and states. Recent research highlights the reactivation of neurodevelopmental programs…”
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TMET-01. LIPID METABOLIC PROGRAMS DEFINE GLIOMA STATE IDENTITY, PLASTICITY AND DEPENDENCIES by Minami, Jenna, Bayley, Nicholas, Tse, Christopher, Andrasz, Cassidy, Cadet, Dimitri, Salinas, Jennifer, Yan, Weihong, Borujerdpur, Amir, Liau, Linda, Cloughesy, Timothy, Williams, Kevin, Bensinger, Steven, Bhaduri, Aparna, Graeber, Thomas, Nathanson, David

“…Abstract Gliomas are lethal malignancies comprised of heterogeneous and dynamic subpopulations of cell states resembling normal neurodevelopmental cell types…”
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TMET-17. LIPID METABOLIC HETEROGENEITY OF GLIOMA CELLULAR STATES REVEALS ENVIRONMENTAL DEPENDENCIES by Bayley, Nicholas, Minami, Jenna, Tse, Christopher, Zhu, Henan, Salinas, Jennifer, Andrasz, Cassidy, Yan, Weihong, Cadet, Dimitri, Borujerdpur, Amir, Williams, Kevin, Bhaduri, Aparna, Bensinger, Steven, Liau, Linda, Cloughesy, Timothy, Graeber, Thomas, Nathanson, David

“…Abstract Malignant growth and survival of cancer is supported through reprogrammed lipid metabolism. In gliomas, genetic alterations can drive lipid metabolic…”
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