Search Results - "Cadenhead, Kristin S."
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Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project
Published in Schizophrenia bulletin (01-03-2015)“…A barrier to preventative treatments for psychosis is the absence of accurate identification of persons at highest risk. A blood test that could substantially…”
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Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk
Published in The American journal of psychiatry (01-02-2020)“…Objective:The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%−25%; improvements in risk prediction…”
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Association of Thalamic Dysconnectivity and Conversion to Psychosis in Youth and Young Adults at Elevated Clinical Risk
Published in JAMA psychiatry (Chicago, Ill.) (01-09-2015)“…Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic…”
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At Clinical High Risk for Psychosis: Outcome for Nonconverters
Published in The American journal of psychiatry (01-08-2011)“…Objective:A major focus of early intervention research is determining the risk of conversion to psychosis and developing optimal algorithms of prediction…”
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Startle reactivity and prepulse inhibition in prodromal and early psychosis: Effects of age, antipsychotics, tobacco and cannabis in a vulnerable population
Published in Psychiatry research (30-07-2011)“…Abstract The use of biomarkers in the study of the prodrome and first episode of psychosis provides a means of not only identifying individuals at greatest…”
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North American Prodrome Longitudinal Study (NAPLS 2): Overview and recruitment
Published in Schizophrenia research (01-12-2012)“…Abstract The North American Prodrome Longitudinal Study (NAPLS) is a consortium of eight programs focusing on the psychosis prodrome. Funded by the National…”
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Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Published in Molecular psychiatry (01-03-2023)“…Progressive grey matter loss has been demonstrated among clinical high-risk (CHR) individuals who convert to psychosis, but it is unknown whether these changes…”
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Cortisol Levels and Risk for Psychosis: Initial Findings from the North American Prodrome Longitudinal Study
Published in Biological psychiatry (1969) (15-09-2013)“…Background Studies of biomarkers of hypothalamic-pituitary-adrenal activity indicate that psychotic disorders are associated with elevated cortisol. This study…”
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Association Between P300 Responses to Auditory Oddball Stimuli and Clinical Outcomes in the Psychosis Risk Syndrome
Published in JAMA psychiatry (Chicago, Ill.) (01-11-2019)“…In most patients, a prodromal period precedes the onset of schizophrenia. Although clinical criteria for identifying the psychosis risk syndrome (PRS) show…”
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Course of Neurocognitive Deficits in the Prodrome and First Episode of Schizophrenia
Published in Neuropsychology (01-01-2010)“…Understanding the trajectory of cognitive changes in the development of schizophrenia may shed light on the neurodevelopmental processes in the beginning stage…”
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Negative symptoms in individuals at clinical high risk of psychosis
Published in Psychiatry research (30-04-2012)“…Abstract Negative symptoms are present in the psychosis prodrome. However, the extent to which these symptoms are present prior to the onset of the first…”
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Validity of the Prodromal Risk Syndrome for First Psychosis: Findings From the North American Prodrome Longitudinal Study
Published in Schizophrenia bulletin (01-09-2009)“…Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These patients were considered at…”
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Association of impaired EEG mu wave suppression, negative symptoms and social functioning in biological motion processing in first episode of psychosis
Published in Schizophrenia research (01-08-2011)“…Abstract Background Event related desynchronization (ERD) of mu waves, or mu suppression, over sensorimotor cortex has been observed in response to…”
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Social decline in the psychosis prodrome: Predictor potential and heterogeneity of outcome
Published in Schizophrenia research (01-01-2021)“…While an established clinical outcome of high importance, social functioning has been emerging as possibly having a broader significance to the evolution of…”
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Premorbid functional development and conversion to psychosis in clinical high-risk youths
Published in Development and psychopathology (01-11-2013)“…Deterioration in premorbid functioning is a common feature of schizophrenia, but sensitivity to psychosis conversion among clinical high-risk samples has not…”
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Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis
Published in Schizophrenia research (01-09-2014)“…Abstract Mismatch Negativity (MMN), an electrophysiological component that represents sensory memory processing, has been proposed as a potential vulnerability…”
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Reduced P3a amplitudes in antipsychotic naïve first-episode psychosis patients and individuals at clinical high-risk for psychosis
Published in Journal of psychiatric research (01-06-2013)“…Abstract Event related potentials (ERP) associated with early sensory information processing have been proposed as possible vulnerability markers for…”
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Current status specifiers for patients at clinical high risk for psychosis
Published in Schizophrenia research (01-09-2014)“…Abstract Background Longitudinal studies of the clinical high risk (CHR) syndrome for psychosis have emphasized the conversion vs non-conversion distinction…”
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Factor structure and heritability of endophenotypes in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS-1)
Published in Schizophrenia research (01-04-2015)“…Abstract Background Although many endophenotypes for schizophrenia have been studied individually, few studies have examined the extent to which common…”
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Hippocampal Connectivity With the Default Mode Network Is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals
Published in Clinical psychological science (01-09-2023)“…Reduced hippocampal volume is an established brain morphological feature of psychiatric conditions. Hippocampal volume is associated with brain connectivity in…”
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