Search Results - "Caddeo, Andrea"

LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol by Caddeo, Andrea, Hedfalk, Kristina, Romeo, Stefano, Pingitore, Piero

“…Human membrane bound O-acyltransferase domain-containing 7 (MBOAT7), also known as lysophosphatidylinositol acyltransferase 1 (LPIAT1), is an enzyme involved…”
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TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD by Caddeo, Andrea, Kowalik, Marta Anna, Serra, Marina, Runfola, Massimiliano, Bacci, Andrea, Rapposelli, Simona, Columbano, Amedeo, Perra, Andrea

“…Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterations, including non-alcoholic fatty liver disease (NAFLD)…”
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Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability by Heidari, Erfan, Caddeo, Andrea, Zarabadi, Kiana, Masoudi, Maryam, Tavasoli, Ali Reza, Romeo, Stefano, Garshasbi, Masoud

“…The membrane bound O-acyltransferase domain-containing 7 (MBOAT7) gene codes for an enzyme involved in regulating arachidonic acid incorporation in…”
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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids by Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., Romeo, Stefano

“…There is a high unmet need for developing treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a…”
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Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis by Caddeo, Andrea, Serra, Marina, Sedda, Francesca, Bacci, Andrea, Manera, Clementina, Rapposelli, Simona, Columbano, Amedeo, Perra, Andrea, Kowalik, Marta Anna

“…Several lines of evidence suggest that the thyroid hormone signaling pathway is altered in patients with NAFLD and that pharmacological strategies to target…”
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Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity by Matilainen, Johanna, Berg, Viivi, Vaittinen, Maija, Impola, Ulla, Mustonen, Anne-Mari, Männistö, Ville, Malinen, Marjo, Luukkonen, Veera, Rosso, Natalia, Turunen, Tanja, Käkelä, Pirjo, Palmisano, Silvia, Arasu, Uma Thanigai, Sihvo, Sanna P, Aaltonen, Niina, Härkönen, Kai, Caddeo, Andrea, Kaminska, Dorota, Pajukanta, Päivi, Kaikkonen, Minna U, Tiribelli, Claudio, Käkelä, Reijo, Laitinen, Saara, Pihlajamäki, Jussi, Nieminen, Petteri, Rilla, Kirsi

“…Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been…”
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Precision medicine and nucleotide-based therapeutics to treat MASH by Caddeo, Andrea, Romeo, Stefano

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity…”
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MBOAT7 in liver and extrahepatic diseases by Caddeo, Andrea, Spagnuolo, Rocco, Maurotti, Samantha

“…Abstract MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It has a catalytic dyad involved in remodelling of…”
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TM6SF2 and PNPLA3: a potential dynamic duo? by Caddeo, Andrea, Mancina, Rosellina M

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3D culture models to study pathophysiology of steatotic liver disease by Caddeo, Andrea, Maurotti, Samantha, Kovooru, Lohitesh, Romeo, Stefano

“…Steatotic liver disease (SLD) refers to a spectrum of diseases caused by hepatic lipid accumulation. SLD has emerged as the leading cause of chronic liver…”
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MBOAT7 is anchored to endomembranes by six transmembrane domains by Caddeo, Andrea, Jamialahmadi, Oveis, Solinas, Giovanni, Pujia, Arturo, Mancina, Rosellina Margherita, Pingitore, Piero, Romeo, Stefano

“…[Display omitted] •MBOAT7 is a protein strongly attached to endomembranes;•In silico analysis predicted a number of TMDs of MBOAT7 ranging from 5 to 12;•In…”
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PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis by Pingitore, Piero, Dongiovanni, Paola, Motta, Benedetta Maria, Meroni, Marica, Lepore, Saverio Massimo, Mancina, Rosellina Margherita, Pelusi, Serena, Russo, Cristina, Caddeo, Andrea, Rossi, Giorgio, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Valenti, Luca, Romeo, Stefano

“…Liver fibrosis is a pathological scarring response to chronic hepatocellular injury and hepatic stellate cells (HSCs) are key players in this process. PNPLA3…”
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Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model by Caddeo, Andrea Marco, Kowalik, Marta Anna, Serra, Marina, Rapposelli, Simona, Columbano, Amedeo, Perra, Andrea

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Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes by Kowalik, Marta A, Taguchi, Keiko, Serra, Marina, Caddeo, Andrea, Puliga, Elisabetta, Bacci, Marina, Koshiba, Seizo, Inoue, Jin, Hishinuma, Eiji, Morandi, Andrea, Giordano, Silvia, Perra, Andrea, Yamamoto, Masayuki, Columbano, Amedeo

“…Cancer cells reprogram their metabolic pathways to support bioenergetic and biosynthetic needs and to maintain their redox balance. In several human tumors,…”
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Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease by Donati, Benedetta, Pietrelli, Alessandro, Pingitore, Piero, Dongiovanni, Paola, Caddeo, Andrea, Walker, Lucy, Baselli, Guido, Pelusi, Serena, Rosso, Chiara, Vanni, Ester, Daly, Ann, Mancina, Rosellina Margherita, Grieco, Antonio, Miele, Luca, Grimaudo, Stefania, Craxi, Antonio, Petta, Salvatore, De Luca, Laura, Maier, Silvia, Soardo, Giorgio, Bugianesi, Elisabetta, Colli, Fabio, Romagnoli, Renato, Anstee, Quentin M., Reeves, Helen L., Fracanzani, Anna Ludovica, Fargion, Silvia, Romeo, Stefano, Valenti, Luca

“…In an increasing proportion of cases, hepatocellular carcinoma (HCC) develops in patients with nonalcoholic fatty liver disease (NAFLD). Mutations in…”
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IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids by Sasidharan, Kavitha, Caddeo, Andrea, Jamialahmadi, Oveis, Noto, Francesca Rita, Tomasi, Melissa, Malvestiti, Francesco, Ciociola, Ester, Tavaglione, Federica, Mancina, Rosellina M, Cherubini, Alessandro, Bianco, Cristiana, Mirarchi, Angela, Männistö, Ville, Pihlajamäki, Jussi, Kärjä, Vesa, Grimaudo, Stefania, Luukkonen, Panu K, Qadri, Sami, Yki-Järvinen, Hannele, Petta, Salvatore, Manfrini, Silvia, Vespasiani-Gentilucci, Umberto, Bruni, Vincenzo, Valenti, Luca, Romeo, Stefano

“…Steatotic liver disease (SLD) prevails as the most common chronic liver disease yet lack approved treatments due to incomplete understanding of pathogenesis…”
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Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia by Caddeo, A., Mancina, R.M., Pirazzi, C., Russo, C., Sasidharan, K., Sandstedt, J., Maurotti, S., Montalcini, T., Pujia, A., Leren, T.P., Romeo, S., Pingitore, P.

“…Type I hyperlipoproteinemia, also known as familial chylomicronemia syndrome (FCS), is a rare autosomal recessive disorder caused by variants in LPL, APOC2,…”
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