Search Results - "Caculitan, Nina"

The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells by Liang, Junyi, Seghiri, Mohamed, Singh, Pradeep Kumar, Seo, Hyeon Gyu, Lee, Ji Yeong, Jo, Yoonjung, Song, Yong Bhum, Park, Chulo, Zalicki, Piotr, Jeong, Jae-Yeon, Huh, Won-Ki, Caculitan, Niña G, Smith, Adam W

“…While the existence and functional role of class C G-protein-coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding…”
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Size-Based Chromatography of Signaling Clusters in a Living Cell Membrane by Caculitan, Niña G, Kai, Hiroyuki, Liu, Eulanca Y, Fay, Nicole, Yu, Yan, Lohmüller, Theobald, O’Donoghue, Geoff P, Groves, Jay T

“…Here we introduce a form of chromatography that can be imposed on the membrane of a living cell. A cell–cell signaling interaction is reconstituted in a hybrid…”
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Pharmacokinetics and Pharmacodynamics of Burixafor Hydrobromide (GPC-100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells, in Mice and Healthy Subjects by Sukhtankar, Devki D, Chang, Li-Wen, Tsai, Cheng-Yuan, Cardarelli, Pina M, Caculitan, Niña G

“…Adequate mobilization of hematopoietic stem cells (HSCs), especially CD34 cells, is necessary for stem cell transplantation in patients with hematological…”
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates by Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G

“…Antibody-drug conjugates (ADC) are designed to selectively bind to tumor antigens via the antibody and release their cytotoxic payload upon internalization…”
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Study of the non-covalent interactions in Langmuir–Blodgett films: An interplay between π−π and dipole–dipole interactions by Tang, Zhexiong, Johal, Malkiat S., Scudder, Paul, Caculitan, Niña, Magyar, Rudolph J., Tretiak, Sergei, Wang, Hsing-Lin

“…This work describes Langmuir–Blodgett (L–B) monolayer and multilayer assemblies constructed from a series of NLO-active azo-benzene derivatives possessing…”
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GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol by Sukhtankar, Devki D., Fung, Juan José, Kim, Mi-na, Cayton, Thomas, Chiou, Valerie, Caculitan, Niña G., Zalicki, Piotr, Kim, Sujeong, Jo, Yoonjung, Kim, SoHui, Lee, Jae Min, Choi, Junhee, Mun, SeongGyeong, Chin, Ashley, Jang, Yongdae, Lee, Ji Yeong, Kim, Gowoon, Kim, Eun Hee, Huh, Won-Ki, Jeong, Jae-Yeon, Seen, Dong-Seung, Cardarelli, Pina M.

“…Autologous Stem Cell Transplant (ASCT) is increasingly used to treat hematological malignancies. A key requisite for ASCT is mobilization of hematopoietic stem…”
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Trial in Progress: An Open-Label, Multi-Center Phase 2 Study to Assess the Safety and Efficacy of Burixafor (GPC-100) and Propranolol with and without G-CSF for the Mobilization of Stem Cells in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplant by Caculitan, Nina, Cardarelli, Josephine M., Khouri, Jack, Suh, Hyung C, Ramanathan, Muthalagu, Woolfrey, Ann

“…Background and Significance: Poor stem cell mobilization with failure to produce the target cell dose of ≥2x10 6 CD34 cells/kg required for autologous stem…”
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Combination of Propranolol and a Novel CXCR4 Antagonist Burixafor (GPC-100) for Enhanced Hematopoietic Cell Mobilization by Sukhtankar, Devki D., Cayton, Thomas, Zalicki, Piotr, Choi, Junhee, Mun, Seonggyeong, Jo, Yoonjung, Kim, Sujeong, Lee, Ji Yeong, Kim, Mi-Na, Chin, Ashley, Ramos, Christian, Huh, Won-Ki, Kim, Sohui, Caculitan, Nina, Jeong, Jae-Yeon, Cardarelli, Josephine M.

“…Burixafor (GPC-100), a novel CXCR4 antagonist, has shown safe and effective mobilization of hematopoietic stem and progenitor cells (HSPC) in a phase I…”
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Biotransformation of ADCs. Pathways and enzymes by Zhang, Donglu, Pillow, Thomas H., Su, Dian, Caculitan, Niña G., Chuh, Joseha, Ma, Yong, Yu, Shang-Fan, Yu, Shuai

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Dynamic Behavior of TCR Microclusters on a Live Cell Investigated by a Gold Nanoparticle Array by Kai, Hiroyuki, Caculitan, Nina, Liu, Eulanca, Fay, Nicole, Yu, Yan, Lohmüller, Theobald, Groves, Jay T.

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In Situ Kinetics of Layer-by-Layer Assembled Nonlinear-Optical-Active Amphiphiles from Dynamic Surface Force Measurements by Caculitan, Niña G, Scudder, Paul H, Rodriguez, Analiz, Casson, Joanna L, Wang, Hsing-Lin, Robinson, Jeanne M, Johal, Malkiat S

“…We report the synthesis and layer-by-layer (LBL) deposition of a class of azo-benzene surfactants with the polycation poly(ethylenimine) (PEI). The different…”
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GPC-100 Is a Novel CXCR4 Inhibitor That Leads to Improved in Vitro Potency and In Vivo Efficacy in Stem Cell Mobilization When Combined with a Beta-Blocker by Fung, Juan Jose, Chiou, Valerie, Lee, Jaemin, Jang, Yongdae, Choi, Junhee, Zalicki, Piotr, Cayton, Thomas, Chin, Ashley, Caculitan, Niña, Kim, SoHui, Lee, Jiyeong, Sukhtankar, Devki, Kim, Eunhee, Cardarelli, Josephine

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Role of Clustering in Determining Spatial Organization at the Immunological Synapse by Hartman, Nina Caculitan

“…Micron-scale assemblies of molecules are thematic in biology, although their mechanism of formation and exact functional role are oftentimes unknown. The…”
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Abstract 732: Toward optimizing CXCR4 inhibition with beta adrenergic blockade to enhance chemotherapy response in acute myeloid leukemia by Loera, Brenda, Zhang, Chunxiao, Cardarelli, Pina M., Caculitan, Niña G., Chien, Sylvia, Dai, Jin, Oehler, Vivian G., Zhang, Jianying, Marcucci, Guido, Becker, Pamela S.

“…Introduction: CXCR4 is a chemokine receptor for CXCL12 that plays a critical role in homing of hematopoietic stem cells (HSCs) to the bone marrow…”
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